Mouse anti Human Calpain I (large subunit, p80)
Catalogue Number: X1013-EXA
| Manufacturer: | ExAlpha |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Mouse Anti-Calpain I, u-Calpain (Large subunit, p80), Monoclonal Antibody |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | 15C10 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | IP, WB, EIA |
Description
Description: The calpains are calcium-dependent cysteine proteases that are widely expressed in mammalian systems. Both m-calpain (calpain II) and µ-calpain (calpain I) are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kD subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca ++ requirements that are suggested by their names. Whereas m-calpain requires millimolar (mM) levels of calcium, µ-calpain is active at micromolar (uM) concentrations of Ca ++. In addition to the ubiquitously expressed m- and µcalpains, some tissue-specific calpains have been identified. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.
Additional Text
Gene Name
CAPN1
Uniprot ID
P07384
Gene ID
823
Purification
Protein A/G Purified
Antibody Clonality
Monoclonal
Application Notes
Use at 0.5-1 ug/ml for ELISA and western blot, 1-2ug/ml for immunoprecipitation.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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