Sheep anti Mouse 3BP2 (SH3 Binding Protein 2)
Catalogue Number: X1090P-EXA
| Manufacturer: | ExAlpha |
| Type: | Primary Antibody |
| Alias: | Sh3bp2, SH3 domain-binding protein 2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 250 ug |
| Host name: | Sheep |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Antibody developed using SH2 domain of the 3BP2 protein fused to GST. |
| Application: | WB |
Description
Description: 3BP2 (SH3 binding protein 2) was identified as a protein binding to the SH3 domain of the Abl proto-oncogene. Murine 3BP2 cDNA encodes a 559 amino acid protein of 85 kDa consisting of an N-terminal PH domain, a C-terminal SH2 domain and intervening proline-rich sequences. 3BP2 interacts via its Sh2 domain with Syk family protein tyrosine kinases Syk, Zap70, Grb2, Cbl, PLC 1 and LAT in T lymphocytes and contributes to the transcriptional activation of NF-AT and AP-1. Mouse 3BP2 is 66% homologous to the human protein at the amino acid level.
Additional Text
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Polyclonal
Application Notes
Detects 3BP2 protein by Western blot analysis. Detects a 85 kDa band in murine fibroblasts transfected with 3BP2. Optimal concentration should be evaluated by serial dilutions.
Uniprot ID
Q06649
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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