Sheep anti Human chx 10 (Visual system homeobox 2) (NT)
Catalogue Number: X1180P-EXA
| Manufacturer: | ExAlpha |
| Type: | Primary Antibody |
| Alias: | Ceh-10 homeodomain-containing homolog |
| Shipping Condition: | Blue Ice |
| Unit(s): | 250 ug |
| Host name: | Sheep |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | |
| Application: | WB, IHC-Fr |
Description
Description: Chx10 is a 46kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.
Additional Text
Gene ID
338917
Gene Name
VSX2
Uniprot ID
P58304
Antibody Clonality
Polyclonal
Application Notes
Detects Chx10 by Western blot at 0.5 to 1 µg/ml. Detects a 46 kDa band in mouse and rat retinal tissue lysates. Optimal concentration should be evaluated by serial dilutions. Suitable for use against recombinant proteins conjugated to OVA, GST, His tags and other.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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