Ral B
Catalogue Number: X1211-EXA
| Manufacturer: | ExAlpha |
| Type: | Other Proteins |
| Alias: | RalB Recombinant G-Protein, G protein |
| Shipping Condition: | Blue Ice |
| Unit(s): | 25 ug |
| Host name: | |
| Clone: | |
| Isotype: | |
| Immunogen: | Recombinant GST protein from E. Coli |
| Application: | WB, AC |
Description
Description: RalB is a member of the Ras-like GTP binding protein family. Ras proteins provide a crucial link in the intracellular signalling cascades. Ras proteins are members of the small G protein family. These proteins are characterized by a molecular weight between 20 and 30 kDa, the ability to bind GTP or GDP and a low intrinsic GTPase activity. These proteins relay signals from the plasma membrane activated by receptor tyrosine kinases to the nucleus via a network of serine/threonine kinases. Ras proteins belong to a family of approximately 40 mammalian and 60 non-mammalian proteins. Ras proteins were first discovered as the hyperactive products of mutant Ras genes which promote cancer by disrupting the normal controls on cell proliferation and differentiation; about 30% of human cancers have mutations in a Ras gene. Ras and Ras-like proteins function as switches, cycling between 2 distinct conformational states, active when GTP is bound and inactive when GDP is bound. Affinity precipitation assays can be used to determine the activation status of Ras and Ras-like family members. This assay is based on the ability of the Ras family effector proteins to interact specifically with the activated GTP-bound form of their target GTPases.
Additional Text
Gene Name
RALB
Uniprot ID
P11234
Gene ID
5899
Application Notes
Ral B protein is provided as a functional G-protein and can be used as a Western blot control for antibodies to Ral B protein or in assays to study to protein-protein interactions of Ral B and related proteins with regulatory proteins.
Storage Note
Product should be stored at -70C. Aliquot to avoid freeze/thaw cycles
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