Rabbit anti Mouse Focal Adhesion Kinase (FAK)
Catalogue Number: X1215P-EXA
| Manufacturer: | ExAlpha |
| Type: | Primary Antibody |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Bacterially expressed fusion protein consisting of the C-terminal 150 amino acids of the mouse FAK |
| Application: | IP, WB |
Description
Description: Focal Adhesion Kinase (FAK) is a 120 kDa tyrosine kinase which become phosphorylated in response to oncogene- and extracellular-matrix integrin-dependent stimulation. Chicken, mouse and human FAK has been isolated and the deduced amino acid sequences showed identity of over 90%. It is expressed in embryonic stem cells, and ubiquitously throughout development, in all adult tissues examined and in many cell lines. The highest expression of FAK is seen in the brain, testes and in osteoclasts. It is distinct from other non-receptor protein tyrosine kinases in that its catalytic domain is flanked by amino- and carboxy-terminal domains of about 400 amino acids each. Also, it does not contain the Src homology 2 or 3 domains, which mediate protein-protein interaction, nor a myristylation site that anchors proteins to the membrane.
Additional Text
Gene Name
PTK2
Gene ID
14083
Uniprot ID
P34152
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Polyclonal
Application Notes
Detect focal adhesion kinase by IP/Western analysis in BALB/c 3T3 fibroblasts1. Detects a 120 kDa band. Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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