Sphingosine 1 Phosphate Receptor 1 (EDG-1)
Catalogue Number: X1217C-EXA
| Manufacturer: | ExAlpha |
| Type: | Cell Lysate |
| Alias: | EDG1 (S1P1) Transfected Cell Positive Control Lysate |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Application: | WB |
Description
Description: EDG-1 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-1 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-1 is expressed in cardiovascular, leukocyte- containing and other tissues.
Additional Text
Application Notes
For use as a positive control with Exalpha's EDG1 (S1P1) polyclonal antibody (Cat. No. X1093P) for Western blot analysis.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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