Lysophosphatidic Acid Receptor 1 (EDG2)
Catalogue Number: X1218C-EXA
| Manufacturer: | ExAlpha |
| Type: | Cell Lysate |
| Alias: | EDG-2 transfected cell lysate |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Application: | WB |
Description
Description: Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca2+]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.
Additional Text
Gene ID
1902
Gene Name
LPAR1
Uniprot ID
Q92633
Application Notes
For use as a positive control with Exalpha's EDG2 (LPA1) polyclonal antibody (Cat. No. C174P) for Western blot analysis.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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