Mouse anti Human Keratin 7 (7, 17)
Catalogue Number: X1259M-EXA
| Manufacturer: | ExAlpha |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | C46 |
| Isotype: | IgG1 |
| Immunogen: | Hybridoma produced by the fusion of splenocytes from mice immunized with cytoskeleton preparation from HeLa cells and mouse myeloma cells. |
| Application: | WB, IHC-Fr |
Description
Description: Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non-keratinizing cells (ie., mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification.
Additional Text
Gene Name
KRT7
Gene ID
3855
Uniprot ID
P08729
Purification
Protein A/G Purified
Antibody Clonality
Monoclonal
Application Notes
Detects keratin 7 and 17 by Western blot. Detects a 54 kDa band, corresponding to keratin 7, and a 46 kDa band, corresponding to keratin 17. Reacts only with keratin 7 in formalin-fixed paraffin-embedded sections. Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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