Mouse anti Human Estrogen Receptor
Catalogue Number: X1262M-NMB
| Manufacturer: | Nordic MuBio |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | RT |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | AER314 |
| Isotype: | IgG1 |
| Immunogen: | Hybridoma produced by the fusion of splenocytes from mice immunized with purified estrogen receptors from calf uterus tumor and mouse myeloma cells. |
| Application: | ELISA, IHC-P, IP, WB, IHC-Fr |
Description
Description: The human estrogen receptor has a molecular weight of 67 kDa and consists of 6 functional domains (domains A-F). Functional mapping of the estrogen receptor has determined a transcriptional promoting activity in the A/B domain. The hormone-binding domain (E domain) is located towards the carboxy terminal, whereas the DNA-binding domain (C domain) is found in the central portion of the molecule. It has been speculated that the presence in breast cancer cells of truncated forms of the estrogen receptor lacking the hormone-binding domain might promote the uncontrolled growth of the tumor.
Additional Text
Gene ID
2099
Gene Name
ESR1
Uniprot ID
P03372
Purification
Protein A/G Purified
Antibody Clonality
Monoclonal
Application Notes
Antibody can be used for staining of human and mouse frozen and paraffin tissue sections. Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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