Lysophosphatidic Acid Receptor 1 CT (EDG-2)
Catalogue Number: X1269B-EXA
| Manufacturer: | ExAlpha |
| Type: | Blocking Peptides |
| Alias: | Blocking peptide for use in Western blotting with Anti-EDG2 (LPA1) (CT) (Cat. No. C174P) |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Application: | WB, Inh-Fun |
Description
Description: Endothelial cell differentiation gene-2 (EDG2), or LPA1, receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG2 (LPA1), also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca2+]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG2 (LPA1) is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG2 (LPA1) receptors (with EDG4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.
Additional Text
Application Notes
For use with EDG2 (LPA1) (CT) polyclonal antibody (Cat. No. C174P).
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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