Sheep anti Chicken Alk2
Catalogue Number: X1482P-EXA
| Manufacturer: | ExAlpha |
| Type: | Primary Antibody |
| Alias: | Activin Receptor-Like Kinase 2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 250 ug |
| Host name: | Sheep |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant protein derived from the extracellular domain of the chicken ALK2 protein. Protein shares significant homology with the mouse, rat and human sequences. |
| Application: | WB |
Description
Description: Activin Receptor-Like Kinase 2 is a member of the superfamily of type I receptors for transforming growth factor- (TGF- ). This receptor binds both activin and bone morphogenic proteins (BMPs). In mice, these receptors are expressed mainly in the extraembryonic visceral endoderm before gastrulation and later in both embryonic and extraembryonic cells during gastrulation. Also, it has been shown that ALK2 associates with and phosphorylates Smad1 and also regulated Smad5 and Smad8 phosphorylation. Additionally, it induces the Tlx2 promoter in the absense of BMP7.
Additional Text
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Polyclonal
Application Notes
Antibody can be used for Western blotting (5-10 µg/ml), immunoprecipitation (5 µg/mg of protein lysate and immunohistochemistry on paraffin embedded tissue sections (5-10 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Gene ID
395246
Gene Name
ATVR1
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
Uniprot ID
Q90ZK6
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