Rabbit anti Human cyclin dependent kinase 2
Catalogue Number: X1541P-EXA
| Manufacturer: | ExAlpha |
| Type: | Primary Antibody |
| Alias: | Anti-Cyclin-Dependent Kinase-2, Phosphorylated; p33cdk2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 20 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | |
| Application: | IP, WB |
Description
Description: Cyclin-Dependent Kinase 2 (CDK2), also known as p33cdk2 is expressed earlier in the cell cycle than is p34cdc2. Like p34cdc2, p33cdk2 associates with cyclin A in human cells. However, kinase activity associated with cyclin A-cdc2 is found only in G2-phase. Cdk2 also complexes with cyclins E, D1, and D3. Cyclin E-cdk2 kinase is active in the G1- and S-phases of the cell cycle and is important (as does cyclin A-cdk2) for the progression from G1-to S-phase. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.
Additional Text
Gene Name
CDK2
Gene ID
1017
Uniprot ID
P24941
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Polyclonal
Application Notes
Antibody can be used for Western blotting (1:2,000 dilution) and immunoprecipitation. Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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