Mouse anti Human Estrogen Receptor
Catalogue Number: X1567M-EXA
| Manufacturer: | ExAlpha |
| Type: | ChIP Validated Antibodies |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | TE111.5D11 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | IP, ChIP, WB, EMSA, Inh-Fun |
Description
Description: The estrogen receptor (ER) gene consists of more than 140kb of genomic DNA divided into 8 exons, being translated into a protein with six functionally discrete domains required for transcription activation function, binding to estrogen response element (ERE) constitutive dimerization, binding to heat shock proteins, and ligand recognition. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.
Additional Text
Purification
Protein A/G Purified
Gene ID
2101
Uniprot ID
P11474
Gene Name
ESRRA
Antibody Clonality
Monoclonal
Application Notes
This antibody can be used gel supershift assays (neat concentration), immunoprecipitation on native and denatured lysate (2 µg/mg of protein lysate), Western blotting (1-2 µg/ml) and chromatin precipitation. Can also be used to block binding of estrogen to the estrogen receptor. Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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