Rabbit anti Human Phosphatidic Acid Phosphatase 2B
Catalogue Number: X1651P-NMB
| Manufacturer: | Nordic MuBio |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | PAP2B |
| Shipping Condition: | RT |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide derived from the phosphatidic acid phosphatase 2B protein |
| Application: | WB, EIA |
Description
Description: Vascular endothelial growth factor and type I collagen inducible protein (VCIP), also known as phosphatidic acid phosphatase 2b (PAP2b), was originally identified in a functional assay of angiogenesis. VCIP/PAP2b exhibits an ArgGlyAsp (RGD) cell adhesion sequence. Immunoprecipitation and fluorescence-activated cell sorting analyses demonstrated that VCIP-RGD is exposed to the outside of the cell surface. Retroviral transduction of VCIP can induce cell aggregation and cell cell interactions, modestly increase p120 catenin expression and promote activation of the Fak, Akt and GSK3 protein kinases. Expression of VCIP promoted adhesion, spreading and tyrosine phosphorylation of Fak, Shc, Cas and paxillin in endothelial cells. PAP2b/VCIP is expressed in close proximity to vascular endothelial growth factor, von Willebrand factor and {alpha}v3 integrin in tumor vasculatures.
Additional Text
Gene ID
8613
Uniprot ID
O14495
Purification
Affinity Purified
Gene Name
PLPP3
Antibody Clonality
Polyclonal
Application Notes
Antibody can be used for Western blotting (see vial for dilution) and EIA. Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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