Rabbit anti Human Lysophosphatidic Acid Acetyltransferse beta

Catalogue Number: X1652P-NMB

Manufacturer:	Nordic MuBio
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	1-AGP acyltransferase 2, 1-AGPAT 2,1-acylglycerol-3-phosphate O-acyltransferase 2, LPAAT-β, 2
Shipping Condition:	RT
Unit(s):	100 ug
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Synthetic peptide derived from the LPAAT- protein
Application:	WB, EIA

Overview

Description

Description: Lysophospholipid acyltransferases (LPLATs) catalyse the addition of fatty acyl moieties to the glycerol backbone of lysophospholipids . In addition to playing a crutial role in the synthesis of structural membrane components the LPLATs are also implicated in cellular signalling responses for cytokines, growth factors and other agonists. Cellular signalling through the interleukin 1 receptor in human mesangial cells and EL-4 cells proceeds by the activation of lysophosphatidic acid acyltransferase (LPAAT). Activation of LPAAT by interleukin 1 results in the generation of unsaturated phosphatidic acid species, that are crucial to the generation of diacylglycerol and interleukin 1 signalling. LPLATs are also involved in signalling for increased interleukin 2 synthesis through the T cell antigen receptor. Activation of T-cells via anti-CD3 stimulation has been shown to increase incorporation of polyunsaturated fatty acids into phosphatidylcholine via lysophosphatidylcholine acyltransferase. Activation of this enzyme is essential for the sustained activation and translocation of protein kinase C.

Additional Text

Gene ID

10555

Gene Name

AGPAT2

Uniprot ID

O15120

Purification

Affinity Purified

Antibody Clonality

Polyclonal

Application Notes

Antibody can be used for Western blotting (5-10 µg/ml) and EIA. Optimal concentration should be evaluated by serial dilutions.

Storage Note

Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Price

£346.00

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