SPARC
Catalogue Number: X1855B-EXA
| Manufacturer: | ExAlpha |
| Type: | Blocking Peptides |
| Alias: | Secreted Protein Acidic and Rich in Cysteine, Secreted modular calcium-binding protein 2, SMOC-2, Smooth muscle-associated protein 2, SMAP-2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | |
| Clone: | |
| Isotype: | |
| Immunogen: | |
| Application: | Blk, Inh-Fun |
Description
Description: SPARC is a key factor in cell-matrix interactions and possibly tumour aggressiveness. The SPARC gene, which encodes a multifunctional glycoprotein with roles in tissue development, remodelling and fibrosis. A regulator of cell-extracellular matrix (ECM) interactions, SPARC represents a major factor in the ECM remodelling occurring during tumour invasion. in silico analysis reveals 4 UTR-SNPs located in the 3 -UTR of the SPARC gene, corresponding to 1474 g a, 1551 g c, 1922 t g and 2072 c t changes, which are significantly associated with tumoral state of the tissue. Of all hits, the 2072 SPARC polymorphism had the best association with cancer. SPARC therefore is a gene involved in a number of diseases including rheumatoid arthritis, scleroderma, tumor development and metastasis. SPARC variants have been detected in tumour samples of patients with acute myeloblastic leukemia (AML).
Additional Text
Gene ID
64094
Gene Name
SMOC2
Uniprot ID
Q9H3U7
Application Notes
Blocking peptide for use with SPARC antibodies (Cat. Nos. X1860P & X1867P).
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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