Trag-3
Catalogue Number: X1869B-NMB
| Manufacturer: | Nordic MuBio |
| Type: | Blocking Peptides |
| Alias: | Taxol resistance-associated gene-3 |
| Shipping Condition: | RT |
| Unit(s): | 50 ug |
| Application: | Blk, Inh-Fun |
Description
Description: The expression of the cancer-testis antigen Taxol resistance-associated gene-3 (TRAG-3) is associated with acquired paclitaxel (Taxol) resistance, and is expressed in a variety of cancers - e.g., breast cancer, leukemia, and melanoma. Overexpressed in taxol-resistant breast cancer line MDA 435(TR) and the doxorubicin-resistant multiple myelanoma lines 8226/Dox(40) and 8226/MDR(10)V. Weakly expressed in kidney. TRAG-3 is an attractive target for immunotherapy of cancer. First identified as a novel cancer/testis antigen, TRAG-3, (Taxol Resistance Associated Gene-3) was initially discovered in a search for new genes involved in drug resistance. Early studies of TRAG-3 revealed a minimal to absent expression in normal tissues and a marked over-expression in many carcinoma cell lines including several melanoma lines. By RT-PCR evaluation of TRAG-3 two transcripts are seen in many carcinoma cell lines with products in the the 799 bp and a second alternatively spliced transcript.
Additional Text
Application Notes
Blocking peptide for use with Trag-3 antibodies (Cat. Nos. X1871P & X1872P).
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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