HDAC1, Human
Catalogue Number: X1876B-EXA
| Manufacturer: | ExAlpha |
| Type: | Blocking Peptides |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | |
| Clone: | |
| Isotype: | |
| Immunogen: | |
| Application: | Blk, Inh-Fun |
Description
Description: Acetylation of the tail of histone is known to cause chromatin to adopt a more open 3D conformation, allowing trans factors grerater access to DNA. Histone acetyltransferases (HATs), complexes interact with sequence-specific activator proteins and target specific genes. In addition to histones, HATs acetylate non-histone proteins, implicating them in a wide variety of regulartory roles for these enzymes. By comparison, histone deacetylation promotes a more closed chromatin conformation and in general leads to repression of gene activity. Mammalian histone deacetylases are divided into three classes on the basis of their similarity to various the yeast deacetylases. Class I (HDACs 1, 2, 3 and 8) related to the yeast Rpd3-like proteins, class II (HDACs 4, 5, 6, 7, 9 and 10) related to yeast Hda1-like proteins and class III related to the yeast protein Sir2. Inhibitors of HDAC have enormous potential as cancer therapeutic agents.
Additional Text
Gene Name
HDAC1
Gene ID
3065
Uniprot ID
Q13547
Application Notes
Blocking peptide for use with HDAC1 antibodies (Cat. Nos. X1847P & X1879P).
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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