Rabbit anti Human Sphingomyelin Synthase 2
Catalogue Number: X2059P-EXA
| Manufacturer: | ExAlpha |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | Phosphatidylcholine:ceramide cholinephosphotransferase 2, Sphingomyelin synthase 2, SMS2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide derived from the human sphingomyelin synthase 2 protein. |
| Application: | WB, IHC |
Description
Description: Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine and then onto ceramide. This also yields diacylglycerol as a side product. The reaction is catalysed by SM synthase, an important enzyme in the regulation of diacylglycerol and ceramide as anti- and proapoptotic stimuli. SM synthesis occurs in the lumen of the Golgi as well as on or at the cell surface. It is uncertain which SM enzyme forms are present at these differnet cellular locations. Human, mouse and Caenorhabditis elegans genomes each contain at least two different SM synthase (SMS) genes. Human SMS1 is localised to the Golgi, SMS2 resides primarily at the plasma membrane.
Additional Text
Gene ID
166929
Gene Name
SGMS2
Uniprot ID
Q8NHU3
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Application Notes
Antibod can be used for Western blotting (1:400 starting dilution) and immunohistochemistry (1:400 starting dilution) Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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