Sphingomyelin Phosphodiesterase 3
Catalogue Number: X2287B-EXA
| Manufacturer: | ExAlpha |
| Type: | Blocking Peptides |
| Alias: | nSMase2; Neutral sphingomyelinase 2; EC 3.1.4.12 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | |
| Immunogen: | |
| Application: | WB |
Description
Description: Sphingomyelin phosphodiesterase 3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these two cellular events independently. It also hydrolyzes sphingosylphosphocholine. Sphingomyelin phosphodiesterase 3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It likely acts as a regulator of postnatal development and participates in bone and dentin mineralization. It is activated by unsaturated fatty acids and phosphatidylserine. it is predominantly expressed in the brain.
Additional Text
Gene ID
55512
Gene Name
SMPD3
Uniprot ID
Q9NY59
Application Notes
For use with Sphingomyelin Phosphodiesterase 3 polyclonal antibodies (Cat. No. X2359P & X2360P).
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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