FBXW7
Catalogue Number: X2337B-EXA
| Manufacturer: | ExAlpha |
| Type: | Blocking Peptides |
| Alias: | F-box and WD-40 domain protein 7, FBXW7, CDC4 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | |
| Immunogen: | Synthetic peptide dervied from the human FBXW7 protein |
| Application: | WB |
Description
Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Additional Text
Uniprot ID
Q969H0
Gene ID
55294
Gene Name
FBXW7
Application Notes
For use with FXBW7 polyclonal antibodies (Cat. No. X2314P & X2336P).
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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