FLAP
Catalogue Number: X2351B-EXA
| Manufacturer: | ExAlpha |
| Type: | Blocking Peptides |
| Alias: | FLAP; Arachidonate 5-lipoxygenase-activating protein; MK 886 binding protein |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | |
| Immunogen: | Synthetic peptide derived from human FLAP protein. |
| Application: | WB |
Description
Description: Seems to be required for the activation of 5-LO (5-lipoxygenase). Could play an essential role in the transfer of arachidonic acid to 5-LO. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Genetic variations in FLAP may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Additional Text
Gene ID
241
Gene Name
ALOX5AP
Uniprot ID
P20292
Application Notes
For use with FLAP polyclonal antibodies (Cat. No. X2318P & X2350P).
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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