SET, Phosphatase 2A Inhibitor I2PP2A
Catalogue Number: X2378B-EXA
| Manufacturer: | ExAlpha |
| Type: | Blocking Peptides |
| Alias: | Template-activating factor I, TAF-I, HLA-DR-associated protein II, PHAPII, Inhibitor of granzyme A-activated DNase, IGAAD2PP2A; IGAAD; I2PP2A; PHAPII; TAF-IBETA |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | peptide |
| Application: | WB |
Description
Description: Human SET was originally identified as part of the SET-CAN fusion gene produced by a somatic translocation event in a patient with acute undifferentiated leukemia. In developing kidney, SET is highly expressed in the zone of nephron morphogenesis. SET has been shown to be a potent and specific inhibitor of protein phosphatase 2A, a family of major serine/threonine phosphatases involved in regulating cell proliferation and differentiation. SET is also involved in the regulation of renal cell proliferation and tumorigenesis. SET mRNA expression is markedly reduced in cells rendered quiescent by serum starvation, contact inhibition, or differentiation. SET protein expression is also much greater in developing rat and human kidney than in fully differentiated, mature kidney. High levels of SET mRNA and SET protein expression arefound in Wilms' tumor, but not in renal cell carcinoma, adult polycystic kidney disease or in transitional cell carcinoma.
Additional Text
Gene Name
SET
Gene ID
6418
Uniprot ID
Q01105
Application Notes
For use with SET polyclonal antibodies (Cat. No. X2088P & X2332P).
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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