Rabbit anti Human Histone H2A.x (pS140)
Catalogue Number: X2752P-NMB
| Manufacturer: | Nordic MuBio |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | H2AFX; H2AX |
| Shipping Condition: | RT |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Phosphopeptide derived from the human histone H2A.x protein. |
| Application: | WB, IHC, EIA |
Description
Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Additional Text
Gene ID
3014
Uniprot ID
P16104
Purification
Affinity Purified
Gene Name
H2ax
Application Notes
Antibody can be used for Western blotting (1-5 µg/ml) and immunohistochemistry (2-5 µg/ml at pH 6.2). Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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