Rabbit anti Human Histone H2A.x (S140)
Catalogue Number: X2754P-EXA
| Manufacturer: | ExAlpha |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | H2AFX; H2AX |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide derived from human histone H2a.x protein. Sequence is unphosphorylated version of peptide used for Cat. No. X2752P |
| Application: | WB, IHC, EIA |
Description
Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Additional Text
Gene ID
3014
Uniprot ID
P16104
Purification
Affinity Purified
Gene Name
H2ax
Antibody Clonality
Polyclonal
Application Notes
Antibody can be used for immunohistochemical staining (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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