Rabbit anti Human DICER1
Catalogue Number: X2756P-NMB
| Manufacturer: | Nordic MuBio |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | Endoribonuclease Dicer; DICER; HERNA |
| Shipping Condition: | RT |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide derived from human DICER1 protein. |
| Application: | WB, IHC, EIA |
Description
Description: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.
Additional Text
Gene Name
DICER1
Uniprot ID
Q9UPY3
Gene ID
23405
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Application Notes
Antibody can be used for immunohistochemical staining (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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