Rabbit anti Human PINK1 (C-Terminal)
Catalogue Number: X2760P-NMB
| Manufacturer: | Nordic MuBio |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | PTEN-induced putative kinase protein 1 |
| Shipping Condition: | RT |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide derived from the C-terminal of the human PINK1 protein. |
| Application: | WB, IHC, EIA |
Description
Description: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
Additional Text
Gene ID
65018
Uniprot ID
Q9BXM7
Gene Name
Pink1
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Application Notes
Antibody can be used for immunohistochemical staining (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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