Histone H2a.x (S140)
Catalogue Number: X2769B-NMB
| Manufacturer: | Nordic MuBio |
| Type: | Blocking Peptides |
| Alias: | H2AFX; H2AX |
| Shipping Condition: | RT |
| Unit(s): | 50 ug |
| Application: | NT, Blk |
Description
Description: This peptide is the immunogen used to make Cat # X2754P. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Blocking Peptide to Cat # X2754P.
Additional Text
Application Notes
Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations