PDX1
Catalogue Number: X2770B-NMB
| Manufacturer: | Nordic MuBio |
| Type: | Blocking Peptides |
| Alias: | Pancreas/Duodenum Homeobox Protein 1; Glucose-sensitive factor; Insulin promoter factor 1; Insulin upstream factor 1 |
| Shipping Condition: | RT |
| Unit(s): | 50 ug |
| Application: | NT, Blk |
Description
Description: This peptide is the immunogen used to make Cat # X2755P.PDX1 ctivates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Blocking Peptide to Cat # X2755P.
Additional Text
Application Notes
Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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