DICER1
Catalogue Number: X2771B-NMB
| Manufacturer: | Nordic MuBio |
| Type: | Blocking Peptides |
| Alias: | Endoribonuclease Dicer; DICER; HERNA |
| Shipping Condition: | RT |
| Unit(s): | 50 ug |
| Application: | NT, Blk |
Description
Description: This peptide is the immunogen used to make Cat # X2756P. Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. Blocking Peptide to Cat # X2756P.
Additional Text
Application Notes
Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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