Biotinylated Human Cystine/glutamate transporter (SLC7A11) Protein-Nanodisc (XCT-HM10NB)
Catalogue Number: XCT-HM10NB-KAT
XCT-HM10NB Image
XCT-HM10NB Image
XCT-HM10NB Image
Biotinylated Human SLC7A11 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-SLC7A11 Antibody, hFc Tag with an affinity constant of 1.55 nM as determined in SPR assay (Biacore T200).
XCT-HM10NB Image
Immobilized Biotinylated Human SLC7A11 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-SLC7A11 Antibody, hFc Tag with the EC50 of 59.3ng/ml determined by ELISA (QC Test).
| Manufacturer: | Kactus |
| Shelf Life: | 6 months |
| Molecular Weight: | The protein has a predicted MW of 68.4 kDa. |
| Physical state: | Liquid |
| Type: | Protein - Conjugated |
| Alias: | Cystine/glutamate transporter; xCT; SLC7A11; CCBR1 |
| Host Cell: | HEK293 cells |
| Shipping Condition: | Dry Ice |
| Unit(s): | 100 ug |
Description
Description: Solute Carrier Family 7 Member 11 (SLC7A11, also known as xCT) is the functional subunit of the Xc- system, an anionic L-cystine/L-glutamate antiporter expressed on the cell surface. SLC7A11 expression is significantly upregulated in several types of cancers in which it can inhibit ferroptosis and favor cancer cell proliferation, invasion and chemoresistance. SLC7A11 expression is also increased in ovarian cancer tissues, suggesting a possible role of this protein as a therapeutic target.
Additional Text
Gene ID
23657
Gene Name
SLC7A11
Uniprot ID
Q9UPY5
Protein Tag
HIS Tag
Storage Note
Valid for 6 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Endotoxin
Less than 1 EU per µg by the LAL method.
Short Description
Recombinant Biotinylated Human Cystine/glutamate transporter (SLC7A11) Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Leu501.
XCT-HM10NB Datasheet
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