Beta catenin Polyclonal Antibody
Catalogue Number: BS-1165R-BSS
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Image provided by One World Lab validation program. U138 cells probed with Rabbit Anti-Beta catenin Polyclonal Antibody (bs-1165R) at 1:50 for 60 minutes at room temperature followed by Goat Anti-Rabbit IgG (H+L) Alexa Fluor 488 Conjugated secondary antibody.
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Image provided by One World Lab validation program. MCF-7 cells probed with Rabbit Anti-Beta catenin Polyclonal Antibody (bs-1165R) at 1:50 for 60 minutes at room temperature followed by Goat Anti-Rabbit IgG (H+L) Alexa Fluor 488 Conjugated secondary antibody.
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Formalin-fixed and paraffin embedded human esophageal cancer labeled with Anti-β-catenin/Catenin β Polyclonal Antibody, Unconjugated (bs-1165R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
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Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-Beta catenin Polyclonal Antibody, Unconjugated(bs-1165R) at 1:200 followed by conjugation to the secondary antibody
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Formalin-fixed and paraffin embedded rat skin labeled with Anti-β-catenin/Catenin β Polyclonal Antibody, Unconjugated (bs-1165R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
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Formalin-fixed and paraffin-embedded rat brain labeled with Anti-β-catenin/Catenin β Polyclonal Antibody, Unconjugated(bs-1165R) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, PE conjugated(bs-0295G-PE)used at 1:200 dilution for 40 minutes at 37°C.
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Formalin-fixed and paraffin-embedded rat skin labeled with Anti-β-catenin/Catenin β Polyclonal Antibody, Unconjugated(bs-1165R) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, PE conjugated(bs-0295G-PE)used at 1:200 dilution for 40 minutes at 37°C.
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Lane 1: human colon carcinoma lysates Lane 2: mouse embryo lysates probed with Anti Beta-catenin/Catenin Beta Polyclonal Antibody, Unconjugated (bs-1165R) at 1:200 in 4C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90min in 37C. Predicted band 92kD. Observed band size: 92kD
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | CTNNB; MRD19; armadillo; Catenin beta-1; Beta-catenin; CTNNB1; OK/SW-cl.35; PRO2286 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human Beta catenin |
| Application: | ELISA, FC, ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
Additional Text
Gene Name
CTNNB1
Gene ID
1499
Uniprot ID
P35222
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Modification
Unmodified
Storage Note
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
bs-1165R Datasheet
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