SignalChem Diagnostics is a subsidiary of SignalChem Lifesciences Corporation specializing in protein engineering for molecular, immunological, and clinical chemistry tests. Focused on quality and powered by innovation, we are a team of researchers dedicated to advancing diagnostic accuracy by delivering top-notch reagents for our clients’ specific needs.

Our product portfolio encompasses a broad range of CRISPR-associated proteins, clinical chemistry enzymes, molecular diagnostic enzymes, allergens, buffers, and kits for effective pathogen detection, identification of genetic conditions, evaluation of cancer risks, and other analyses. To ensure proper protein processing, we use diverse expression systems comprising bacteria, yeast, insect, plant, and mammalian cells, while our unique purification method preserves the integrity of post-translational modifications and proteins’ biological functions. Developed with in-depth research and thorough testing, SignalChem Diagnostics reagents meet industry’s highest standards.

Products

MOLECULAR DIAGNOSTICS-RELATED

IMMUNODIAGNOSTICS

CRISPR ASSOCIATED PROTEINS

Enzymes

Isothermal Amplification Enzymes

Affinity Proteins and Resins

What We Do

Plant Expression Systems

We are committed to delivering safe and scalable alternatives for your research needs. With our expertise in finding the best expression and production solutions

CRISPR Technology: The molecular diagnostics and gene editing revolution

The game-changer in the biotechnology industry, paving the way for a future of personalized medicine and sustainable innovation.

Revolutionizing Diagnostics through Innovative R&D

We are dedicated to discovering new and innovative raw materials, as well as improving existing ones, to ensure the highest quality and performance of our products

“All-in-one” Development & Manufacturing

Control and flexibility over the production process, faster turnaround times and high-quality products

Quality Assurance

Consistently delivering high-quality products and services to customers

Custom Products

We create tailored diagnostic solutions that meet specific needs and research goals

The Value of IVD Raw Materials

In vitro diagnostics (IVD) raw materials are pivotal to revolutionary diagnostic advancements, profoundly impacting countless lives. These indispensable components enable the creation of precise, efficient, and dependable diagnostic tests and assays.
The significance of IVD raw materials extends beyond their scientific merits. They equip researchers with the power to identify diseases earlier, monitor patients’ health, and make well-informed treatment decisions, leading to life-altering diagnostic tools.
IVD raw materials pave the way for personalized medicine, promoting accurate diagnoses and informed treatment choices. They play a pivotal role in enhancing patient outcomes, reducing healthcare expenses, and improving the overall quality of life globally.
In today’s interconnected world, IVD raw materials assume a critical role in upholding global health security. Swift and accurate diagnostic tools are indispensable for managing emerging infectious diseases and protecting public health.
Behind every diagnostic breakthrough stands a devoted team of scientists, researchers, and manufacturers, tirelessly working to guarantee the quality of IVD raw materials. Their unwavering commitment empowers researchers to make a genuine, lasting impact on people’s lives, embodying hope, healing, and enhanced health for millions worldwide.

Applications

CANCER RESEARCH

SignalChem Diagnostics provides a range of CRISPR-associated proteins and enzymes as raw materials, which can be adapted for various research and diagnostic applications.

These CRISPR components can be employed to develop assays that detect cancer-related mutations, circulating tumor DNA, or other molecular markers specific to cancer.

By incorporating these raw materials into innovative detection methods, researchers and diagnostic companies can create cutting-edge diagnostic tools to improve cancer detection and monitoring.

CLINICAL CHEMISTRY

SignalChem Diagnostics provides a range of enzymes that have various applications in Clinical Chemistry. These enzymes play crucial roles in the measurement of different analytes in biological samples, which can help in diagnosing and monitoring a variety of medical conditions.

For instance, cholesterol oxidase is utilized in the assessment of total cholesterol levels, while glucose-6-phosphate dehydrogenase is employed in diagnosing genetic disorders. Other enzymes, such as hexokinase, D-lactate dehydrogenase, malate dehydrogenase, and uricase, also have important functions in clinical chemistry, aiding in the analysis of glucose, D-lactate, malate, and uric acid levels, respectively.

Overall, these raw materials are essential for the accurate and efficient functioning of diagnostic tests in clinical laboratories.

COVID-19

SignalChem Diagnostics offers products like COVID-19 proteins, antibodies, and nanobodies that are vital for designing diagnostic assays, including serological tests. These tests detect antibodies against SARS-CoV-2 in a patient’s blood, indicating past or ongoing infection. Accurate tests are crucial for dianosis, monitoring virus spread, and assessing population immunity.

Cell lines and COVID-19 inhibitors aid in researching the virus’s biology and interaction with human cells. This knowledge informs the development of diagnostic tools, such as identifying novel viral antigens or host biomarkers for targeted diagnostic tests.

These products provide essential raw materials and tools for researchers and diagnostic companies to develop and enhance COVID-19 diagnostic tests, ultimately improving detection, monitoring, and public health strategies.

MOLECULAR DIAGNOSIS

SignalChem Diagnostics provides a range of molecular biology products, including enzymes and proteins, that are essential in DNA and RNA manipulation, amplification, and synthesis.

These products find applications in molecular diagnostics and research, such as PCR and qPCR for amplifying and detecting specific DNA sequences, reverse transcription for converting RNA into complementary DNA, and DNA repair and recombination studies.

By offering these products, SignalChem Diagnostics supports the development of diagnostic tools, research methodologies, and molecular biology techniques.

IMMUNOLOGY RESEARCH

SignalChem Diagnostics provides allergens as products, which can be utilized in allergy research, diagnostics, and treatment.

These allergens play an essential role in understanding the immune response to specific allergens, improving diagnostic tests for allergy identification, and developing immunotherapies for treating allergies.

By offering these allergnes, SignalChem Diagnostics contributes to the advancement of allergy-related knowledge, diagnostic accuracy, and treatment efficacy.

RAW MATERIALS

SignalChem Diagnostics produces various raw materials that have a wide range of applications in diagnostics, research, and biotechnology.

These raw materials include enzymes, proteins, allergens, and CRISPR components, among others. These raw materials are essential for the development of diagnostic tests, research methodologies, and the advancement of molecular biology techniques.

By offering these products, SignalChem Diagnostics supports innovation and progress in the fields of diagnostics, research, and biotechnology.

Products

IMMUNODIAGNOSTICS

SignalChem Diagnostics offers an exclusive range of anti-human antibodies designed to meet the demands of various immunodiagnostic assays. Our high-quality monoclonal antibodies target Human IgA, IgG, and IgM, providing exceptional specificity and sensitivity. Unconjugated and optimized for a wide array of applications, these antibodies ensure reliable performance in ELISA, Western blot, immunoprecipitation, and other immunoassay techniques.

Antibodies

Name	Catalog #	Expression Host Organism	Isotype/Class
Anti-Human IgG Antibody mIgM, Unconjugated	H38-60M	N/A	Mouse, IgM
Anti-Human IgM Antibody mIgG, Unconjugated	H38M-60M	N/A	Mouse, IgG

Allergens

Name	Catalog Number	Source Organism	Expression Host Organism	Tag Type	Genbank Number
Alt a 1	AL01-A931H	Alternaria alternata	E.coli	His	AY117038.1
Art V 3.02	AV02-A921H	Artemisia vulgaris	E.coli	His	EU564845.1
Asp f 3	AF03-A931H	Aspergillus fumigatus	E.coli	His	U58050.1
Asp f 5	AF05-A931H	Aspergillus fumigatus	E.coli	His	Z30424.1
Asp f 6	AF06-A931H	Aspergillus fumigatus	E.coli	His	U53561.1
Asp f 9	AF09-A931H	Aspergillus fumigatus	E.coli	His	AJ223327.1
Can f 1	CF01-A951H	Canis familiaris	E.coli	His	AF027177.1
Can f 2	CF02-A951H	Canis familiaris	E.coli	His	AF027178.1
Can f 3	CF03-A951H	Canis familiaris	E.coli	His	AB090854.1
Can f 5	CF05-A951H	Canis familiaris	E.coli	His	Y00751
Cra c 8	CC08-A951H	Crangon crangon	E.coli	His	FJ462738.1
Der f 1	DF01-A941H	Dermatophagoides farinae	E.coli	His	AB034946.1
Der f 2	DF02-A941H	Dermatophagoides farinae	E.coli	His	D10447.1
Der p 2	DP02-A941H	Dermatophagoides pteronyssinus	E.coli	His	AF276239.1
Der p 21	DP21-A941H	Dermatophagoides pteronyssinus	E.coli	His	DQ354124.1
Der p 21/23	DP22-A941H	Dermatophagoides pteronyssinus	E.coli	His	Der p 21: DQ354124.1 Der p 23: EU414751.1
Der p 23	DP23-A941H	Dermatophagoides pteronyssinus	E.coli	His	EU414751.1
Der p 7	DP07-A941H	Dermatophagoides pteronyssinus	E.coli	His	U37044.1
Fel d 1	FD01-A951H	Felis catus	E.coli	His	chain 1: NM_001048153.1 chain 2: NM_00104.1
Lit v 2	LV02-A951H	Litopenaeus vannamei	E.coli	His	DQ975203.1
Lit v 3	LV03-A951H	Litopenaeus vannamei	E.coli	His	EU449515.1
Lit v 4	LV04-A951H	Litopenaeus vannamei	E.coli	His	FJ184279.1
Pen ch 18	PC18-A961H	Penicillium chrysogenum	E.coli	His	AF264027.1
Art v 1	AV01-A921H	Artemisia vulgaris	Tobacco	His	AF493943.1
Art v 3	AV03-A921H	Artemisia vulgaris	Tobacco	His	EU564845.1
Man i 3	MN03-A921H	Mangifera indica	Tobacco	His	DQ270547.1

Kits

Name	Catalog Number
Guinea Pig Adenovirus (ADV) ELISA Kit	CADV1-876
Guinea Pig Cytomegalovirus (CMV) ELISA Kit	CCMV1-876
Guinea Pig Tyzzer’s Disease (Clostridium piliforme) (CPIL) ELISA Kit	CCP01-876
Mouse Ectromelia Virus (EV) ELISA Kit	MEV01-876
Mouse Hepatitis Virus (MHV) ELISA Kit	MHV01-876
Mouse Lymphocytic Choriomeningitis Virus (LCMV) ELISA Kit	LCMV1-876
Mouse Mycoplasma pulmonis (MP) ELISA Kit	MMP01-876
Mouse Norovirus ELISA Kit	MNV01-876
Mouse Parvovirus ELISA Kit	MPV01-876
Mouse Pneumonia Virus (MPV) ELISA Kit	MPV02-876
Mouse Sendai Virus (SV) ELISA Kit	MSV01-876
Mouse Theiler’s Murine Encephalomyelitis Virus (TMEV) ELISA Kit	MTV01-876
Rat Hantavirus (HV) ELISA Kit	RHV01-876
Rat Parvovirus (PV) ELISA Kit	RPV01-876
Rat Sialodacryoadenitis Virus (SDAV) ELISA Kit	RSAV1-876

MOLECULAR DIAGNOSTICS-RELATED PRODUCTS

SignalChem Diagnostics offers a comprehensive selection of high-quality molecular enzymes, specifically designed to enhance the performance and reliability of molecular diagnostic applications. Our product range includes enzymes for efficient cDNA synthesis, reliable PCR amplification, and accurate qPCR analysis. Carefully optimized and rigorously tested, these enzymes and master mixes provide consistent results, making them ideal for various molecular diagnostic assays.

Enzymes

Name	Catalog #	Source Organism	Expression Host Organism
High Fidelity Master Mix	HF01-E011	N/A	N/A
High Fidelity Master Mix (Dye Plus)	HF01-E012	N/A	N/A
M-MLV (H-) Reverse Transcriptase	RTM01-E311	Moloney Murine Leukemia Virus (M-MLV)	E. coli
Murine RNase Inhibitor	RNI01-G511	Mouse (Mus musculus)	E. coli
PureScript II Pro Reverse Transcriptase	RTH02-E311	Moloney Murine Leukemia Virus (M-MLV)	E. coli
PureScript III Pro Reverse Transcriptase	RTH03-E311	Moloney Murine Leukemia Virus (M-MLV)	E. coli
Super Fidelity DNA Polymerase	SF01-E311	N/A	N/A
Super Fidelity Master Mix	SF01-E011	N/A	N/A
Super Mix For qPCR (+gDNA Wiper)	RTS01-E011	N/A	N/A
Taq Plus DNA polymerase	TQ02-E311	Thermus aquaticus	E. coli
Taq Plus Master Mix	TQ02-E011	N/A	N/A
Taq Plus Master Mix (Dye Plus)	TQ02-E012	N/A	N/A
Taq Pro Universal SYBR qPCR Master Mix	TQ03-E011	N/A	N/A

Reagents

Name	Catalog #	Application
dNTP Mix	DN01-09	N/A
Nucleic Acid Detection Test Strip	TS02-NA89	N/A

Isothermal Amplification Enzymes

Name	Catalog #	Source Organism	Expression Host Organism
ATP-dependent DNA helicase RecQ, Active	AH01-E311H	E. coli	E. coli
Bst II Pro DNA Polymerase Large Fragment	BP01-E311	Bacillus stearothermophilus	E. coli
Bsu DNA Polymerase Large Fragment	BD01-E311U	Bacillus subtilis	E. coli
Sau DNA Polymerase Large Fragment	SD01-E311U	Staphylococcus. aureus	E. coli
Single-stranded DNA binding protein	SS01-C501H	E. coli	E. coli
T4 gp32 Protein	T4G32-C501H	Escherichia virus T4	E. coli
T4 UvsX DNA Recombinase	T4SX-E311U	Escherichia virus T4	E. coli
T4 UvsY Protein	T4SY-C501H	Escherichia virus T4	E. coli

CRISPR ASSOCIATED PROTEINS

SignalChem Diagnostics offers a comprehensive portfolio of CRISPR-associated proteins, featuring a diverse range of highly active CRISPR enzymes tailored to meet the demands of cutting-edge gene-editing applications. Our selection of CRISPR enzymes ensures exceptional specificity, efficiency, and versatility in various CRISPR-based gene manipulation techniques, enabling the development of innovative and reliable gene-editing solutions.

Enzymes

Name	Catalog #	Source Organism	Expression Host Organism	Tag Type	Sequence
AapCas12b, Active	C12B1-E311U	Alicyclobacillus acidiphilus	E. coli	tag-free	full length
AsCas12a, Active	CS12A-E311H	Acidaminococcus sp	E. coli	His	full length
Cas12 (LbCpf1), Active	C12CR-E241G	Lachnospiraceae	E. coli	GST	full-length
EiCsm6, Active	CS06-E312H	Enterococcus italicus	E. coli	His	full length
LbuCas13a, Active	CS13A-E322U	Leptotrichia buccalis	E. coli	tag-free	full length
LwCas13a, Active	CS13A-E321H	Leptotrichia wadei	E. coli	His	full length
PsmCas13b, Active	CS13B-E312H	Prevotella sp	E. coli	His	full length
SpCas9 (D10A)-NLS	CS09N-E331H	Streptococcus pyogenes	E. coli	His	full length
SpCas9 (D10A, H840A)-NLS	CS09N-E333H	Streptococcus pyogenes	E. coli	His	full length
SpCas9 (H840A)-NLS	CS09N-E332H	Streptococcus pyogenes	E. coli	His	full length
SpCas9, Active	CS09-E311H	Streptococcus pyogenes	E. coli	His	full length
SpCas9-NLS, Active	CS09N-E312H	Streptococcus pyogenes	E. coli	His	full length with a nuclear localization sequence for optimal activity
SpCas9-NLS, Active, Glycerol-free	CS09N-E312HB	Streptococcus pyogenes	E.coli	His	full length
TccCas13a, Active	CS13A-E314H	Thermoclostridium caenicola	E. coli	His	full length
TtCsm6, Active	CS06-E311H	Thermus thermophilus	E. coli	His	full length

Reagents

Name	Catalog #	Application
CAS System Nucleic Acid Detection Test Strip	TS01-CS89	N/A
Cas12 Reaction Buffer, 10X	CS12-09	Reaction buffer for Cas12 activity assays
Cas13 Reaction Buffer II, 10X	CS13-09B	Reaction buffer for Cas13 activity assays
Cas13 Reaction Buffer, 10X	CS13-09	Reaction buffer for Cas13 activity assays
Cas13 Storage Buffer, 1X	CS13-19	Storage buffer for Cas13 enzymes

gRNA Design Tool

Custom Guide RNAs

We provide expertly synthesized and tailored custom guide RNAs for a wide range of research applications, including specialized projects. Our Alt-R Custom Guide RNAs are the perfect choice for prime editing (pegRNA) initiatives, CRISPR-Cas13 applications, and the majority of alternative CRISPR-Cas systems, ensuring optimal performance and adaptability for your unique research needs

Kit

Product Name	Catalog #
Cas12 (AapCas12b) Kit	C12B1-U834
Cas12 (LbCpf1, GST) Kit	C12CR-G834
Cas12 (LbCpf1, His) Kit	C12CR-H834
Cas13 (LbuCas13a) Kit	CS13A-U834
Cas13 [LwCas13a (LwC2c2)] Kit	CS13A-H834

CLINICAL CHEMISTRY

SignalChem Diagnostics offers a diverse range of enzymes specifically designed for clinical chemistry applications, ensuring optimal performance in diagnostic tests and assays. Our high-quality enzyme selection has been rigorously tested for accuracy, sensitivity, and consistency, enabling precise quantification and detection of analytes in various clinical chemistry tests.

Enzymes

Name	Catalog #	Enzyme No.	Grade	Activity
Cholesterol Oxidase	CX01D1-E311H	EC 1.1.3.6	Diagnostic Reagent	12U/mg-solid or more
D-Lactate dehydrogenase	LD01D1-E311H	EC 1.1.1.28	Diagnostic Reagent	150U/mg-solid or more
Glucose-6-phosphate dehydrogenase	GD03D1-E311H	EC 1.1.1.49	Diagnostic Reagent	280U/mg-solid or more
Hexokinase	HK01D1-E311H	EC 2.7.1.1	Diagnostic Reagent	150U/mg-solid or more
Malate dehydrogenase	MD01D1-E311H	EC 1.1.1.37	Diagnostic Reagent	40U/mg-solid or more
Uricase	UR01D1-E311H	EC 1.7.3.3	Diagnostic Reagent	4U/mg-solid or more

Co-Factors

Name	Catalog#	Cas #	Molecular Formula
Nicotinamide Adenine Dinucleotide (NAD)	NA01-C59	53-84-9	C21H27N7O14P2
Nicotinamide Adenine Dinucleotide Phosphate Disodium Salt (NADP-Na2)	NN02-C59	24292-60-2	C21H26N7O17P3 Na2
Nicotinamide Adenine Dinucleotide Phosphate Monosodium Salt (NADP-Na)	NN01-C59	1184-16-3	C21H27N7O17P3 · Na
Nicotinamide Adenine Dinucleotide Phosphate Reduced Form (NADPH) tetrasodium salt	NR01-C59	2646-71-1	C21H26N7Na4O17P3
Nicotinamide Adenine Dinucleotide Reduced Form (NADH) disodium salt	NH01-C59	606-68-8	C21H27N7O14P2 Na2
Nicotinamide Mononucleotide (NMN)	NM01-C59	1094-61-7	C11H15N2O8P
β-Thionicotinamide Adenine Dinucleotide oxidized form free acid (β-Thio-NAD)	TN01-C59	4090-29-3	C21H27N7O13SP2

COVID-19 RELATED PRODUCTS

SignalChem Diagnostics offers an extensive array of COVID-19 related proteins, designed to support cutting-edge research in diagnostics, therapeutics, and vaccine development. Our product line includes various forms of the SARS-CoV-2 Spike protein, Nucleocapsid protein, non-structural proteins (NSPs), and key enzymes, as well as human proteins involved in virus-host interactions. These high-quality, recombinant proteins are carefully produced and validated to ensure optimal performance and consistency across a wide range of applications.

Proteins

Name	Catalog #	Source Organism	Expression Host Organism	Tag Type	Sequence
2019-nCoV 3CLpro, Active	C19CL-G242H	2019-nCoV (virus)	E.coli	His	full-length
2019-nCoV 3CLpro, Active	C19CL-G241H	2019-nCoV (virus)	E.coli	His	full-length
2019-nCoV NSP10/NSP16 Methyltransferase, Active	C19NS-E301H	2019-nCoV (virus)	E.coli	His	heterodimer of full length NSP10 (A4254-Q4392) and NSP16 (S6799-N7096)
2019-nCoV NSP14 Methyltransferase, Active	C19NS-E311H	2019-nCoV (virus)	E.coli	His	5925-6452
2019-nCoV NSP7 Protein	C19N7-E541H	2019-nCoV (virus)	E.coli	His	full-length
2019-nCoV NSP8 Protein	C19N8-E541H	2019-nCoV (virus)	E.coli	His	full-length
2019-nCoV Nucleocapsid (N) Protein	C19NP-G242H	2019-nCoV (virus)	E.coli	His	full-length
2019-nCoV Nucleocapsid protein CTD	C19ND-G241H	2019-nCoV (virus)	E.coli	His	237-419
2019-nCoV PLpro, Active	C19PL-G241H	2019-nCoV (virus)	E.coli	His	full-length
2019-nCoV RdRp, Active	C19RP-G241H	2019-nCoV (virus)	E.coli	His	full-length
2019-nCoV Spike protein RBD (K417T, E484K, N501Y), HRP conjugated	C19SD-G231AD	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with K417T, E484K, N501Y, conjugated to HRP
2019-nCoV Spike protein RBD (L452R, E484Q), HRP conjugated	C19SD-G231DD	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with L452R, E484Q, conjugated to HRP
2019-nCoV Spike protein RBD (L452R, T478K), HRP conjugated	C19SD-G231FD	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with L452R, T478K, conjugated to HRP
2019-nCoV Spike protein RBD (R346K, E484K, N501Y)	C19SD-G231NH	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with R346K, E484K, N501Y
2019-nCoV Spike protein RBD (Y449H, E484K, N501Y)	C19SD-G231PH	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with Y449H, E484K, N501Y
2019-nCoV spike protein RBD (E484K)	C19SD-G237H	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with E484K
2019-nCoV Spike protein RBD (E484Q)	C19SD-G231CH	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with E484Q
2019-nCoV Spike protein RBD (IHU)	C19SD-G231RH	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with IHU � R346S, N394S, Y449N, E484K, F490S, N501Y
2019-nCoV Spike protein RBD (K417N)	C19SD-G236H	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with K417N
2019-nCoV Spike protein RBD (K417N, E484K, N501Y) (Beta variant)	C19SD-G232H	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with K417N, E484K, N501Y
2019-nCoV Spike protein RBD (K417N, E484K, N501Y), HRP conjugated	C19SD-G232D	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with K417N, E484K, N501Y, conjugated to HRP
2019-nCoV Spike protein RBD (K417N, L452R, T478K)	C19SD-G231LH	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with K417N, L452R, T478K
2019-nCoV Spike protein RBD (K417T)	C19SD-G239H	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with K417T
2019-nCoV Spike protein RBD (K417T, E484K and N501Y)	C19SD-G231AH	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with K417T, E484K, N501Y
2019-nCoV Spike protein RBD (L452Q, F490S)	C19SD-G231MH	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with L452Q, F490S
2019-nCoV Spike protein RBD (L452R)	C19SD-G235H	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with L452R
2019-nCoV spike protein RBD (L452R, E484Q)	C19SD-G231DH	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with L452R, E484Q
2019-nCoV Spike Protein RBD (L452R, T478K)	C19SD-G231FH	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with L452R T478K
2019-nCoV Spike protein RBD (N439K)	C19SD-G233H	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with N439K
2019-nCoV Spike protein RBD (N440K)	C19SD-G231EH	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with N440K
2019-nCoV Spike protein RBD (N501Y)	C19SD-G231H	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with N501Y
2019-nCoV Spike protein RBD (N501Y), HRP conjugated	C19SD-G231D	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with N501Y, conjugated to HRP
2019-nCoV Spike protein RBD (S477G)	C19SD-G231BH	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with S477G
2019-nCoV Spike protein RBD (S477N)	C19SD-G238H	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with S477N
2019-nCoV Spike protein RBD (Y453F)	C19SD-G234H	2019-nCoV (virus)	CHO cells	His	RBD (319-541) with Y453F
2019-nCoV Spike protein RBD, HRP conjugated	C19SD-G241D	2019-nCoV (virus)	CHO cells	His	319-541, conjugated to HRP
2019-nCoV Spike protein RBD, Fc Tag	C19SD-G241F	2019-nCoV (virus)	CHO cells	Fc	319-541
2019-nCoV Spike protein RBD, HIS Tag	C19SD-G241H	2019-nCoV (virus)	CHO cells	His	319-541
2019-nCoV Spike protein S1 (?69-70, N501Y, D614G)	C19S1-G237H	2019-nCoV (virus)	CHO cells	His	(16-685) with ?69-70, N501Y, D614G
2019-nCoV Spike protein S1 (?69-70, Y453F, D614G)	C19S1-G231AH	2019-nCoV (virus)	CHO cells	His	S1(16-685) with ?69-70, Y453F, D614G
2019-nCoV Spike protein S1 (T19R, ?157-158, L452R, T478K, D614G, P681R)	C19S1-G231FH	2019-nCoV (virus)	CHO cells	His	S1(16-685) with T19R, ?157-158, L452R, T478K, D614G, P681R
2019-nCoV Spike protein S1 (T95I, Y144T, Y145S, ins146N, R346K, E484K, N501Y, D614G, P681H)	C19S1-G231MH	2019-nCoV (virus)	CHO cells	His	S1(16-685) with T95I, Y144T, Y145S, ins146N, R346K, E484K, N501Y, D614G, P681H
2019-nCoV Spike protein S1 (?69-70 ?144 N501Y A570D D614G P681H)	C19S1-G239H	2019-nCoV (virus)	CHO cells	His	S1(16-685) with ?69-70 ?144 N501Y A570D D614G P681H
2019-nCoV Spike protein S1 (?69-70)	C19S1-G234H	2019-nCoV (virus)	CHO cells	His	(16-685) with ?69-70
2019-nCoV Spike protein S1 (?69-70, N439K, D614G)	C19S1-G231BH	2019-nCoV (virus)	CHO cells	His	S1(16-685) with ?69-70, N439K, D614G
2019-nCoV spike protein S1 (?Y145, ?H146, E484K, D614G)	C19S1-G231DH	2019-nCoV (virus)	CHO cells	His	S1(16-685) with ?Y145, ?H146, E484K, D614G
2019-nCoV Spike protein S1 (A222V)	C19S1-G233H	2019-nCoV (virus)	CHO cells	His	(16-685) with A222V
2019-nCoV Spike protein S1 (A222V, D614G)	C19S1-G235H	2019-nCoV (virus)	CHO cells	His	(16-685) with A222V, D614G
2019-nCoV Spike protein S1 (D614G)	C19S1-G231H	2019-nCoV (virus)	CHO cells	His	S1(16-685) with D614G
2019-nCoV Spike protein S1 (IHU)	C19S1-G231RH	2019-nCoV (virus)	CHO cells	His	S1(16-685) with IHU � E96Q, ?136-144, R190S, D215H, R346S, N394S, Y449N, E484K, F490S, N501Y, D614G, P681H
2019-nCoV Spike protein S1 (K417N, E484K, N501Y, D614G)	C19S1-G238H	2019-nCoV (virus)	CHO cells	His	S1(16-685) with K417N, E484K, N501Y,D614G
2019-nCoV Spike protein S1 (L452R, E484Q, D614G, P681R)	C19S1-G231EH	2019-nCoV (virus)	CHO cells	His	(16-685) with L452, E484Q, D614Q, P681R
2019-nCoV Spike protein S1 (N501Y, D614G)	C19S1-G236H	2019-nCoV (virus)	CHO cells	His	(16-685) with N501Y, D614G
2019-nCoV Spike protein S1 (P681H)	C19S1-G232H	2019-nCoV (virus)	CHO cells	His	S1(16-685) with P681H
2019-nCoV Spike protein S1 (T19R, G142D, del157-158, L452R, T478K, D614G, P681R)	C19S1-G231LH	2019-nCoV (virus)	CHO cells	His	S1(16-685) with T19R, G142D, ?157-158,L452R, T478K, D614G, P681R
2019-nCoV Spike protein S1 (T95I, G142D, E154K, L452R, E484Q, D614G, P681R)	C19S1-G231KH	2019-nCoV (virus)	CHO cells	His	S1(16-685) with T95I, G142D, E154K, L452R, E484Q, D614G, P681R
2019-nCoV Spike protein S1, Fc Tag	C19S1-G241F	2019-nCoV (virus)	CHO cells	Fc	16-685
2019-nCoV Spike protein S1, HIS Tag	C19S1-G241H	2019-nCoV (virus)	CHO cells	His	16-685
2019-nCoV Spike protein S2, Fc Tag	C19S2-G241F	2019-nCoV (virus)	CHO cells	Fc	686-1212
2019-nCoV Spike RBD-N Protein Chimera	C19NSD-G242H	2019-nCoV (virus)	CHO cells	His	2019-nCoV�s N-terminal Spike S1 RBD (319-541) fused to Nucleocapsid (237-419) protein with a linker HSA (human serum albumin)
ACE2 (18-739) Protein	A53C2-G341F	dog	CHO cells	Fc	18-739
ACE2 (18-740) Protein	A52C2-G341F	rat	CHO cells	Fc	18-740
ACE2 (19-740) Protein	A51C2-G341F	human	CHO cells	Fc	19-740
CD147 (22-205) Protein	C81D7-G651F	human	CHO cells	Fc	22-205
CD147 (22-205) Protein	C81D7-G651H	human	CHO cells	His	22-206
DPP4 (29-766) Protein	DP4CD-G441H	human	CHO cells	His	29-766
MERS Spike Protein RBD	MERSD-G241F	MERS-CoV (virus)	CHO cells	Fc	377-588
SARS-CoV Spike Protein RBD	SARSD-G241F	SARS-CoV (virus)	CHO cells	Fc	318-510
SARS-CoV Spike Protein S1, Fc Tag	SARS1-G241F	SARS-CoV (virus)	CHO cells	Fc	14-680
SARS-CoV Spike Protein S1, HIS Tag	SARS1-G241H	SARS-CoV (virus)	CHO cells	His	14-680

Inhibitors

Name	Catalog #	CAS Registration Number	Molecular Formula
ACE2 (18-615) Protein	A51C2-G342F
Bafilomycin A1	V115-905	88899-55-2	C35H58O9
Camostat Mesilate	S565-906	59721-29-8	C20H22N4O5 • CH3SO3H
Captopril	A51-906	62571-86-2	C9H15NO3S
Chloroquine phosphate	C119-905	50-63-5	C18H26ClN3 · 2H3PO4
Hydroxychloroquine	T860-905	747-36-4	C18H26ClN3O · H2SO4
INK-128	F17-901C		C15H15N7O
Losartan potassium	S35-908	124750-99-8	C22H22ClN6O · K
Mycophenolic acid	I23-905	24280-93-1	C17H20O6
Niclosamide	S54-900	50-65-7	C13H8Cl2N2O4
Nitazoxanide	P312-905	55981-09-4	C12H9N3O5S
Ponatinib	A03-900	943319-70-8	C29H27F3N6O
RVX-208	B17-905B	1044870-39-4	C20H22N2O5
Tofacitinib	J01-900	477600-75-2	C16H20N6O
Valinomycin	V113-908	2001-95-8	C54H90N6O18
Verapamil HCl	V114-908	152-11-4	C27H38N2O4 · HCl

Antibodies

Catalog #	Product Name
C19NP-60DH	Anti 2019-nCoV N-Protein hIgG Antibody, HRP conjugated
C19NP-60H	Anti 2019-nCoV N-Protein hIgG Antibody
C19S1-60DH	Anti 2019-nCoV Spike Protein hIgG Antibody, HRP conjugated
C19S1-60H	Anti 2019-nCoV Spike Protein hIgG Antibody
C19S1-6101M	Anti-2019-nCoV Spike (681P) (8G10A1)
C19S1-6102M	Anti-2019-nCoV Spike (681P) (8G10B1)
C19S1-6103M	Anti-2019-nCoV Spike (681P) (8G10C8)
C19S1-61H	Anti 2019-nCoV Spike Protein hIgG Antibody
C19S1-61MH	Anti 2019-nCoV Spike Protein mIgG Antibody
C19S1-6701M	Anti-2019-nCoV Spike (P681H) Mutant (9F7E4)
C19S1-6701R	Anti-2019-nCoV Spike (P681H) Mutant
C19S1-6702M	Anti-2019-nCoV Spike (P681H) Mutant (1G8D11)
C19S1-6703M	Anti-2019-nCoV Spike (P681H) Mutant (7A4D12)
C19S1-6704M	Anti-2019-nCoV Spike (P681H) Mutant (7C11H11)
C19S1-A60H	Anti 2019-nCoV Spike Protein hIgA Antibody
C19S1-M60H	Anti 2019-nCoV Spike Protein hIgM Antibody

Nanobodies

Product Name	Catalog #
Anti 2019-nCoV Spike Protein Neutralizing Nanobody (NBX20010)	C19S1-641HL
Anti 2019-nCoV Spike Protein Neutralizing Nanobody (NBX20014)	C19S1-644HL
Anti 2019-nCoV Spike Protein Neutralizing Nanobody (NBX20025)	C19S1-643HL
Anti 2019-nCoV Spike Protein Neutralizing Nanobody (NBX20038)	C19S1-642HL
Anti-2019-nCoV Spike Protein Neutralizing Nanobody (NBX20014)	C19S1-654L
Anti-2019-nCoV Spike Protein Neutralizing Nanobody (NBX20025)	C19S1-653L
Anti-2019-nCoV Spike Protein Neutralizing Nanobody (NBX20038)	C19S1-652L

Cell Lines

Name	Catalog #
Human ACE2 Stable Cell line-CHO	A51C2-71C

Assay Kits

Product Name	Catalog #
2019-nCoV Delta Variant Neutralization ELISA Kit	C19SD-ND887
2019-nCoV High Sensitivity S1 Protein ELISA Kit	C19S1-876
2019-nCoV N-S1 Human IgA ELISA Kit	C19NS1-A877
2019-nCoV N-S1 Human IgG ELISA Kit	C19NS1-877
2019-nCoV N-S1 Human IgG-IgA-IgM ELISA Kit	C19NS1-P877
2019-nCoV N-S1 Human IgM ELISA Kit	C19NS1-M877
2019-nCoV Neutralization ELISA Kit	C19SD-N887
2019-nCoV S1 Human IgA ELISA Kit	C19S1-A877
2019-nCoV S1 Human IgG ELISA Kit	C19S1-877
2019-nCoV S1 Human IgG-IgA-IgM ELISA Kit	C19S1-P877
2019-nCoV S1 Human IgM ELISA Kit	C19S1-M877
2019-nCoV S1 Protein ELISA Kit	C19SD-876

GENERAL REAGENTS PRODUCTS

Introducing our General Reagents product category, a comprehensive range of essential laboratory components designed to support a variety of scientific applications. Within this category, you will find a diverse selection of enzymes, buffers, and other high-quality products that play a pivotal role in facilitating accurate and reliable experimental outcomes.Each product within our General Reagents category undergoes rigorous quality control processes, ensuring superior performance and reproducibility. Our commitment to excellence is rooted in the trust we place in our team of scientists and experts who continuously strive to deliver products of the highest standard. Discover the reliability and versatility of our General Reagents collection, designed to elevate your scientific endeavors by providing the essential building blocks for successful experimentation.

Enzymes

Name	Catalog#	Species	Expr.System
Endonuclease	EN01-E311U
Proteinase K, Active (MBG)	P535-30N	Parengyodontium album (tritirachium album)	Pichia pastoris

Affinity Proteins & Resins

Name	Catalog#	Source Organism	Expression Host Organism	Tag Type	Genbank Accession#
Protein A	PA01-S551H	Staphylococcus. aureus	E. coli	His	CAE54483.1
Protein A Resin	PA01-RA551	N/A	N/A	N/A	N/A
Protein G	PG01-S551H	Streptococcus Sp.	E. coli	His	N/A
Protein L	PL01-S551H	Finegoldia magna	E. coli	His	N/A
Streptavidin	ST01-E511U	Streptomyces avidinii	E. coli	tag-free	X03591
Streptavidin	ST01-E511H	Streptomyces avidinii	E. coli	His	X03591

Support

Custom Products

Discover Customization Excellence

Unlock the full potential of your research with SignalChem Diagnostics’ custom services! Our top-notch team of experienced scientists provide you with personalized solutions for your specific needs, making your experiments a success. We offer a range of tailored services, including:

Concentration Modification

Ensure optimal performance of our products by adjusting their concentration to match your experimental needs. With our concentration modification service, proteins and reagents can be precisely formulated to your desired concentration, streamlining your workflow and improving the accuracy and reproducibility of your research.

Tag Modification

Maximize compatibility and functionality of our proteins by selecting the perfect tag for your needs. Our skilled team can assist in adding, removing, or altering existing tags to suit your experimental requirements. Tag modification allows for better protein solubility, simplified purification processes, and enhanced detection in various applications.

Buffer Modification

Customize the buffer composition of our products to achieve ideal conditions for your experiments. Our team can expertly modify the buffer system, pH, and other additives to accommodate your specific requirements. This bespoke service ensures that our products seamlessly integrate into your experimental setup, maximizing the potential for success.

But Not Limited To That

Our extensive capabilities empower us to assist you in developing the precise product required to achieve your objectives. Our team of skilled scientists will guide you through the process, thoroughly analysing your requirements to tailor your final product precisely to your specifications.

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CRISPR Technology

CRISPR technology is a groundbreaking tool that has transformed the field of biotechnology. With its ability to accurately and efficiently modify DNA, CRISPR has opened up new possibilities for scientific research, medical treatments, and even agricultural applications. Its precision and versatility make it an invaluable tool for discovering and developing new therapies for genetic diseases, as well as for improving crop yields and enhancing food security. As one of the most exciting breakthroughs in modern science, CRISPR technology holds immense promise for shaping the future of biotechnology and improving lives worldwide. Find out what SignalChem Diagnostics has to offer.

SignalChem Diagnostics – your partner in innovative, reliable, and efficient research solutions

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Plant Expression System

Embrace the Future of Allergy Detection with Plant Expression Systems

The use of plant expression systems is revolutionizing allergy detection by offering an innovative and efficient approach to allergen production. By harnessing the power of plant expression systems, researchers can effectively study allergens, advance allergy research, and improve diagnostics. Dive into the fascinating world of allergy detection using plant expression systems and discover how this technology is shaping the future of allergy research and diagnostics.

Impact of Plant Expression Systems on Allergy Detection

High-Level Allergen Production

Plant expression systems enable the production of allergen products with unparalleled levels of expression, providing researchers and clinicians with invaluable tools to gain deeper insights into allergy mechanisms, diagnostics, and treatments.

Proper Protein Folding and Post-Translational Modifications

Allergen products produced using plant expression systems ensure correct protein folding and precise post-translational modifications, essential for their structural, functional, and biological properties. These attributes are crucial for accurate allergy detection and understanding allergen-host interactions.

Safety and Scalability

Plant expression systems minimize the risk of contamination with human pathogens, offering a safer alternative to traditional expression systems like bacterial, yeast, and mammalian cell cultures. Moreover, the production process is easily scalable, allowing for efficient allergen production to cater to diverse research needs and projects of any size.

Innovative Research Opportunities

The use of plant expression systems opens up new avenues for allergy research, including the study of allergen structures, host response, and novel diagnostic methods. These advancements ultimately contribute to a better understanding of allergies and the development of more effective treatments.

Potential for Personalized Medicine

Plant expression systems offer the potential to develop personalized allergy diagnostics and treatments. By tailoring allergen products to individual patient needs, clinicians can potentially improve diagnostic accuracy and create customized treatment plans for more effective allergy management.

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On-site Development and Manufacturing

Unparalleled Control, Flexibility, and Quality – All-In-One Place

We understand the importance of rapid development and reliable manufacturing for IVD raw materials. That’s why we are invested in providing cutting-edge, on-site development and manufacturing that to caters to your specific needs. Our seamless process guarantees faster turnaround times and exceptional product quality, giving you the competitive advantage, you deserve.

Key Features

Complete Control and Flexibility

We have complete control over the entire production process, from concept to completion. This flexibility allows for seamless integration of your specifications and requirements, ensuring products are tailored to your needs.

Faster Turnaround Times

Say goodbye to long wait times and delays! Our On-Site Development & Manufacturing services are designed to optimize efficiency and streamline production giving you an edge in today’s fast-paced world.

Unmatched Quality

Our commitment to excellence is evident in every aspect of our production process. Our state-of-the-art facility is equipped with the latest technology, and our highly skilled team is dedicated to ensuring that your product meets or exceeds the highest industry standards.

Innovative Solutions

At Signalchem Diagnostic, we pride ourselves on our ability to provide innovative diagnostic solutions that meet the diverse needs of our clients. Our on-site development and manufacturing service allows us to stay at the forefront of industry advancements and provide you with cutting-edge products.

Expert Support

Our team of experienced professionals is here to support you every step of the way, from product conception to delivery. We are committed to providing you with exceptional customer service and ensuring that your experience with Signalchem Diagnostic is nothing short of outstanding.

Don’t settle for anything less than the best. Contact us now to discuss your project requirements!

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Quality Assurance

Our unwavering commitment to excellence ensures that we consistently deliver top-tier products and services to our valued customers. Our enhanced Quality Assurance (QA) program is meticulously designed to maintain the highest possible standards throughout every stage of product development and service delivery.

Key Features

Rigorous Testing Protocols

Our expert team conducts thorough and systematic testing at multiple checkpoints, verifying that each product or service meets or exceeds industry benchmarks and customer expectations.

Continuous Improvement

Our QA program is dynamic and adaptive, utilizing customer feedback and data-driven insights to implement ongoing improvements, guaranteeing the consistent delivery of superior products and services.

Comprehensive Documentation

We maintain extensive records and documentation for every product and service, providing full transparency and traceability for our customers and regulatory bodies.

State-of-the-art Facilities

Our cutting-edge facilities are equipped with advanced technology and equipment, allowing us to maintain the utmost precision and accuracy throughout the development and production processes.

Expertise & Training

Our skilled professionals undergo rigorous training and participate in ongoing education to stay ahead of industry advancements, ensuring that they possess the knowledge and skills necessary to maintain our high-quality standards.

Experience the difference that our dedication to excellence can make for your diagnostic needs.

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Rapid Detection and Surveillance

Prompt Identification for Effective Health Management

By prioritizing rapid detection and surveillance, we provide researchers and diagnostic product developers with high-quality IVD raw materials, enabling them to quickly and accurately identify health threats. This ultimately leads to better decision-making, improved control and management of potential risks, and overall advancements in the field of diagnostics.

Key Advantages

Expedited Results

By leveraging advanced technologies and stringent quality control, our raw materials for IVD can significantly expedite the diagnostic process, enabling scientists to swiftly obtain reliable results and make timely decisions for improved results and test performances.

Enhanced Surveillance Capabilities

Our Covid-19 antigens facilitate the tracking and monitoring of emerging health threats, empowering researchers to stay informed and respond effectively.

Wide Range of Applications

Our comprehensive suite of raw materials for IVD caters to various sectors, including human health, veterinary and agriculture diagnostics, ensuring a broad scope of applications from detection to surveillance.

User-Friendly Solutions

We prioritize the development of easy-to-use diagnostic components and platforms, making our raw materials for IVD accessible to researchers and diagnostic product developers across diverse settings.

Continuous Research & Development

Our unwavering dedication to R&D drives the continuous improvement and expansion of our product portfolio, ensuring that our raw materials remain at the forefront of diagnostics detection and surveillance.

Partner with SignalChem Diagnostics for solutions that prioritize speed, accuracy, and innovation.
Together, we can make a significant impact on global health and safety.

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