Titermax

TiterMax® adjuvants are used to produce cell mediated and humoral responses in research animals.
TiterMax® adjuvants were developed to meet the specific needs of investigators for immunoadjuvants that are at least as effective as Freund's Complete Adjuvant, safer and easier to use.
They are an attractive alternative to Freund's Complete Adjuvant for use by researchers in inducing antibody to diverse antigens.

The key to the potency of TiterMax® adjuvants lies both in the immunostimulatory activity of their components and in the fact that they form a stable water-in-oil emulsion.
TiterMax® adjuvants contain three essential ingredients: Proprietary block copolymers, squalene, a metabolizable oil, and a unique microparticulate stabilizer.

Like Freund's Complete Adjuvant, TiterMax® adjuvants can be used with a wide variety of antigens because they can entrap any antigen in a water-in-oil emulsion.
TiterMax® adjuvants aid in the antigens effective presentation to the immune system without the toxic effects of Freund's Complete Adjuvant.


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TiterMax Classic

TiterMax Gold


TiterMax® adjuvants are used to produce cell mediated and humoral responses in research animals.  TiterMax® adjuvants were developed to meet the specific needs of investigators for immunoadjuvants that are at least as effective as Freund’s Complete Adjuvant, safer and easier to use.  They are an attractive alternative to Freund’s Complete Adjuvant for use by researchers in inducing antibody to diverse antigens.  The key to the potency of TiterMax® adjuvants lies both in the immunostimulatory activity of their components and in the fact that they form a stable water-in-oil emulsion.  TiterMax® adjuvants contain three essential ingredients: Proprietary block copolymers, squalene, a metabolizable oil, and a unique microparticulate stabilizer.  Like Freund’s Complete Adjuvant, TiterMax® adjuvants can be used with a wide variety of antigens because they can entrap any antigen in a water-in-oil emulsion.  TiterMax® adjuvants aid in the antigens effective presentation to the immune system without the toxic effects of Freund’s Complete Adjuvant.


FAQs

Q. What does TiterMax® contain?

A. TiterMax® contains the following:

 

Q. What is block copolymer CRL-8941?

A. CRL-8941 is a synthetic polymer composed of blocks or chains of hydrophobic polyoxypropyline (POP) and hydrophilic polyoxyethylene (POE). The adjuvant activity of block copolymers was described in 1981 by Hunter et al. CRL-8941 was selected for its adjuvant activity which is typical of other block copolymers and its ability to form stable water-in-oil emulsions with squalene.

 

Q. How should TiterMax® be stored?

A. TiterMax® should be stored at 4° C.

 

Q. Can TiterMax® be stored and re-used after it has been emulsified with an antigen?

A. A 50:50 water-in-oil emulsion can usually be stored at room temperature, 4° C, -20° C, or -70° C for as long as your antigen is stable. Upon storage, approximately 20% of the oil will disassociate from the emulsion. You may leave the emulsion in a syringe and simply re-emulsify when you are ready to use again for injecting. The stability of an emulsion will depend upon the inherent stability of the antigen.

 

Q. Is TiterMax® reliable?

A.

TiterMax® has the reliability and reproducibility of FCA.

TiterMax® can be used reliable with virtually any antigen because, like FCA,

TiterMax® can entrap any antigen in a water-in-oil emulsion; which is critical for dependable adjuvant activity. In contrast, many new adjuvants simply bind antigens by adsorption. If the antigens do not adsorb, they seldom induce high antibody titers.

TiterMax® combines the benefits of a water-in-oil emulsion with those of potent block copolymer adjuvants, yielding highly reproducible results.

 

Q. In what volumes may I purchase TiterMax®?

A.TiterMax® can be purchase in 0.5, 1.0, 5.0, and 10.0 ml vials to fit all of your research needs.