SARS-CoV-2 Virus Neutralization

SARS-CoV-2 spike protein ligand binding BioAssay™ kit allows rapid quantification of COVID-19 neutralizing antibodies in serum and plasma by measuring reduction in the binding of viral spike protein with its receptor ACE2. This assay allows rapid analysis of convalescent plasma, antibody-based therapeutics, vaccine leads, and immune response to the virus. This serological platform was designed as a tool to begin understanding the correlation between neutralizing antibody level and protective immunity in recovered SARS-CoV-2.

  • Rapid: 1.5 hours total time
  • Versatile: No cells or virus used, therefore suitable for USL1 lab
  • Open Platform: 96 well plate reader
  1. Enzyme conjugated SARS-CoV-2 spike protein is mixed with serum for testing, and applied to ACE2 precoated microtiter plate.
  2. Neutralizing antibodies:Spike protein:ACE2 equilibrium is reached.
  3. Plate is washed and developed with TMB.
  4. Signal can be calibrated using a standard curve using pre- made calibrators containing purified blocking antibodies or monoclonal blocking antibodies.
USBio Catalog # Product Name
544523 SARS-CoV-2 Virus Neutralization BioAssay™


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