Signalchem COVID-19

Research Solutions for Coronavirus – Signalchem

The COVID-19 outbreak due to the novel SARS-CoV-2 virus has turned into a global pandemic infecting hundred thousands of people worldwide. With a rapid rate of infection and a high mortality rate, it is estimated that the novel COVID-19 can infect millions of people all over the globe. Quick intervention at this stage to curb further spread becomes crucial and can only be achieved through expediting critical life science research. Scientists and clinicians around the world are focusing on understanding the molecular biology and mechanisms adapted by COVID-19, and its lethal mode of action. To understand the virus completely and develop safe therapeutic interventions, scientists require a range of trusted molecular biology reagents such as high-quality recombinant proteins related to SARS-CoV-2.
SignalChem, a global leader in cell signaling and protein engineering, has been devoting resources in creating and developing new research tools related to SARS-CoV-2 virus since the outbreak. With the help of advanced bioengineering technology to produce active proteins and AI drug development capability, we have already established expression systems for production of SARS-CoV-2 Spike proteins, RBD fragments, N protein, and other related protein products on a large scale to help detect IgG / IgM in potential patients. These proteins can be used as diagnostic standard antigens and can serve as targets of neutralizing antibodies under development and can also be used by scientists in their development of antibodies to detect SARS-CoV-2 virus in patients. In addition, SignalChem uses mammalian and insect cell expression systems in its production of these protein products as this is more immunogenic than the protein expressed from the E. coli system.

Covid-19 testing products

Code Name Size Sample type
N02092-B COVID-19 IgG / IgM antibody detection kit (finger prick) 1000 tests Human blood, serum or plasma
8100805 Sample Collection Kit for Throat Sampling 100 preps Throat swabs
8100812 Sample Collection Kit for Nasal Sampling 100 preps Nasal swabs

COVID-19 Related Products

Name Cat# Species Tag Expression System Sequence GenBank Number
2019-nCoV PLpro, Active C19PL-G241H Virus HIS E.coli 1564-1882 QHD43415
2019-nCoV Spike protein RBD C19SD-G241H Virus HIS CHO cells 319-541 MN908947
2019-nCoV Spike protein RBD C19SD-G241F Virus Fc CHO cells 319-541 MN908947
2019-nCoV Spike protein S1 C19S1-G241F Virus Fc CHO cells 16-685 MN908947
2019-nCoV Spike protein S1 C19S1-G241H Virus HIS CHO cells 16-685 MN908947
ACE2 (18-615) Protein A51C2-G342F Human Fc CHO cells 18-615 AF291820
ACE2 (19-740) Protein A51C2-G341F Human Fc CHO cells 19-740 AF291820
Anti-2019nCoV Spike Protein C19S1-61H Human, IgG1 CHO cells
Anti-Human IgG, Unconjugated H38-60M Mouse, IgM
Anti-Human IgM, Unconjugated H38M-60M Mouse, IgG
METTL3/METTL14, Active M323-380G Human GST Sf9 insect cells using baculovirus Full Length NM_019852

COVID-19 ELISA Kits

Code Name Type
C19SD-876 2019-nCoV S1 Protein ELISA Kit 96 well plate pre-coated with recombinant human ACE2 protein
C19S1-877 2019-nCoV S1 Human IgG ELISA Kit 96 well plate pre-coated with recombinant 2019-nCoV spike protein

COVID-19 Related Inhibitors

Name Catalog Number CAS Registration Number Molecular Formula Purity Chemical Name
Bafilomycin A1 V115-905 88899-55-2 C35H58O9 >98% (HPLC); NMR (conforms) (-)-Bafilomycin A1
Camostat Mesilate S565-906 59721-29-8 C20H22N4O5 • CH3SO3H >98% (HPLC); NMR (Conforms) 4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate, methanesul-fonic acid salt; FOY-305; Foipan
Captopril A51-906 62571-86-2 C9H15NO3S >98% (HPLC, TLC); NMR (conforms) (2S)-1-(3-mercapto-2-methyl-propionyl)-L-proline
Chloroquine phosphate C119-905 50-63-5 C18H26ClN3 · 2H3PO4 >98% (TLC); NMR (conforms) N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine, diphosphate
Hydroxychloroquine T860-905 747-36-4 C18H26ClN3O · H2SO4 >98% (TLC); NMR (conforms) 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline, sulfate.
Losartan potassium S35-908 124750-99-8 C22H22ClN6O · K >99% (TLC); NMR (conforms) 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol, potassium salt (DUP-753)
Mycophenolic acid I23-905 24280-93-1 C17H20O6 >98% (HPLC); NMR (conforms) 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexanoic acid; NSC129185
Niclosamide S54-900 50-65-7 C13H8Cl2N2O4 >98% (TLC); NMR (conforms) 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Nitazoxanide P312-905 55981-09-4 C12H9N3O5S >98% (HPLC); NMR (conforms) O-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenyl acetate; NTZ
RVX-208 B17-905B 1044870-39-4 C20H22N2O5 >98% (TLC); NMR (conforms) 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone
Valinomycin V113-908 2001-95-8 C54H90N6O18 >98% (HPLC); NMR (conforms) Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
Verapamil HCl V114-908 152-11-4 C27H38N2O4 · HCl >98% (TLC); NMR (conforms) α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile, hydrochloride

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