elabscience covid-19

Research Solutions for Coronavirus – Elabscience

Ready-to-Use COVID-19 IgG/IgM Rapid Test Kit

COVID-19 IgG/IgM Rapid Test Kit

For suspicious patients with symptoms, mild symptoms, or even without symptoms

COVID-19(Corona Virus Disease) is an infectious disease caused by the most recently discovered coronavirus. This highly contagious new virus and disease were unknown before the outbreak began in Wuhan, China which spread all over the world very quickly. COVID 19 IgG/IgM Rapid Test (Whole Blood/ Serum/Plasma) is a rapid chromatographic immunoassay for the qualitative detection of IgG and IgM antibodies to COVID 19 in human whole blood, serum or plasma as an aid in the diagnosis of primary and secondary COVID 19 infections.

Product Information

Catalog No.:	UNCOV-40
Principle:	GICA
Specimen:	Human Serum, Plasma or Whole Blood
Format:	Cassette
Reading Time:	10 minutes
Package:	40T/kit
Reagents :	Test Cassette, Buffer, Dropper, Desiccant.

Product Advantages

Easier: No special equipment needed, Intuitive visual interpretation.

Rapid: Quick sampling by fingertip blood, Result in 10 15min.

Accurate: Results with IgG and IgM respectively, validated using PCR and CT.

Application: For suspicious patients with symptoms, mild symptoms, or even without
symptoms, also for testing people with close contact of infected patients and people under
quarantine control.

Product Performances

Sensitivity: 98.81% (95% CI: 97.25%, 99.61%)

Specificity: 98.02% (95% CI: 97.05%, 98.74%)

Test Procedures

1. Sample collection and preparation.

2. Keep the kit and sample to room temperature prior to testing.

3. Add sample to the sample well using a micropipette.

4. Add buffer to the sample well.

5. Wait for the colored line(s) to appear and read the result at 10 minutes .

Interpretations of Results

IgM Positive: indicated of primary COVID 19 infection.

IgG and IgM Positive: indicated of secondary COVID 19 infection.

IgG Positive: indicated of past COVID 19 infection.

Negative: indicated of no previous infection.

Invalid: indicating that the experiment is failed.

Other Products*

*for research use only

Elab

E-HD-C044

Human Corona Virus Disease 2019 (COVID-19) IgG/IgM Lateral Flow Assay Kit (Whole Blood/ Serum/ Plasma)

RUO Antibody based Test kit

40 tests

Raw Material for COVID-19 IVD Rapid Test Development

Raw materials for IVD

With the now global outbreak of COVID-19, a fast, convenient and specific method for in vitro diagnosis of COVID-19 infection is urgent for fighting and preventing this disease. Elabscience® is not only providing the SARS-CoV-2 (2019-nCoV) IgG/IgM Lateral Flow Assay Kit for SARS-CoV-2 research, but also providing raw materials for development of COVID-19 IgG/IgM Rapid Test in IVD use.

Advantages

High specificity
Bulk in stock
Fast for use
Cost-effective

COVID-19 IgG/IgM Rapid Test Development Kit

This kit contains essential reagents for the development of COVID-19 IgG/IgM Lateral Flow (Rapid Test) assay to help with the qualitative detection of IgG and IgM antibodies specific to SARS-CoV-2 in human biological fluids.

View more details about raw materials for COVID-19 IV

Raw Materials for COVID-19 IgG/IgM Rapid Test Kit

The raw materials including the most important reagents, antigen and antibodies, can be also available separately.

Cat. No.	Product Name	Size
E-ELC-001	Recombinant SARS-CoV-2 N Protein (His Tag)	1/5/10 mg
E-ELC-002	Recombinant SARS-CoV-2 N Protein (with colloidal gold conjugated)	1/5/10 mL
E-ELC-003	Mouse anti-human IgG monoclonal	1/5/10 mg
E-ELC-004	Mouse anti-human IgM monoclonal	1/5/10 mg
E-ELC-005	Goat anti-chicken IgY polyclonal	1/5/10 mg
E-ELC-006	Chicken IgY(with colloidal gold conjugated)	1/5/10 mL
E-ELC-008	Buffer for Rapid Test Development(02)	1000/5000/10000 Tests

With the now global outbreak of COVID-19, SARS-CoV-2 early diagnostics and infection prevention and control has become critical. Elabscience^® can also provide the following antibodies for SARS-CoV-2 (2019-nCoV, COVID-19 virus) research:

Proteinase K

Proteinase K
Proteinase K is a kind of high activity proteinase of subtilisin, which is used to degrade proteins in biological samples. It can be used to digest various proteins, and it can be used in a variety of molecular biology, cell biology and other related experiments, such as genomic DNA extraction, enzyme digestion and removal, cell permeability and so on.
Proteinase K is mainly used for the production of nucleic acid extraction kit, especially for nucleic acid extraction from samples of nucleic acid diagnosis and detection in vitro diagnosis (IVD) industry.

Shortage of supply
Due to the outbreak of “2019-nCOV”, the demand for nucleic acid detection is soaring, and the supply of raw materials for detection reagents is also very tight, including Proteinase K extracted from nucleic acid.

A large wave of Proteinase K is coming!
In order to alleviate the supply pressure of Proteinase K and provide sufficient raw material support for the detection of new coronavirus, our R&D team with strong strength of Elabscience® has solved the problems of batch production time, product quality and yield in a short time by using the international leading protein purification platform.

Brand	Elabscience®
Product	Proteinase K Lyophilized Powder
Cat.No.	E-IR-R109U
Nature	Recombination
Valid Period	2~8°C for two years. RT for one year.
Purity	≥95% by SDS-PAGE
Application	Genomic DNA Purification Kit, RNA Purification Kit, Gene Diagnostic Kit, IHC, ISH and other possible application.
Activity	≥30 U/mg
Capacity	15~20 kg/Month

Product characteristics

Recombinant expression in yeast
Activity ≥30 U/mg
DNase and RNase free
Recommend usage 50~200 μg/mL

Activity result
Elabscience® standard production process requires that the activity ratio ≥30 U/mg. In fact, the activity ratio exceeded the expected production standard, content the application requirements of customers.
Unit definition: One unit is defined as the amount of enzyme that catalyzes the formation of 1 μmol of tyrosine per minute at pH 7.5 at 37°C.

Calibration curve
According to the absorbance A275 for the vertical axis, the different concentrations of tyrosine as the horizontal axis, the standard curve was drawn.

Detection of DNase and RNase residues
Use DNase and RNase detection kit to detect the DNase and RNase residues with different Lots of Proteinase K. The results showed that there were no DNase nor RNase in Proteinase K.

SARS-CoV/CoV-2 (2019-nCoV) Antibodies

Since the SARS-CoV-2-Spike protein and Nucleocapsid Protein (NP) are the biomarkers of 2019-nCoV, and angiotensin convertenzyme 2 (ACE-2) is the main surface receptor to SARS-CoV-2 , it is important to fully understand the role these proteins play in SARS-CoV-2 infection. Elabsicnece^® offers a variety of antibodies to investigate the mechanisms of the SARS-CoV-2 life cycle.

Molecule	Cat. No.	Product Name	Applications
SARS-CoV-2 Spike	E-AB-V1001	SARS-COV-2 Spike Monoclonal Antibody(2019-nCoV)	ELISA
	E-AB-V1002	SARS-COV-2 Spike Monoclonal Antibody(2019-nCoV)	ELISA
	E-AB-V1003	SARS-COV-2 Spike Monoclonal Antibody(2019-nCoV)	IF,ELISA
	E-AB-V1005	SARS-COV-2 Spike S1 Monoclonal Antibody(2019-nCoV)	IF,ELISA
	E-AB-V1006	SARS-COV-2 Spike RBD Polyoclonal Antibody(2019-nCoV)	WB,ELISA
SARS-CoV-2-NP	E-AB-V1011	SARS-COV-2 NP Monoclonal Antibody(2019-nCoV)	ELISA
	E-AB-V1012	SARS-COV-2 NP ScFv Monoclonal Antibody(2019-nCoV)	ELISA
	E-AB-V1013	SARS-COV-2 NP Monoclonal Antibody(2019-nCoV)	WB,ELISA
	E-AB-V1014	SARS-COV-2 NP Monoclonal Antibody(2019-nCoV)	WB,ELISA
ACE2	E-AB-12224	ACE2 Polyclonal Antibody	IHC,ELISA
ACE2	E-AB-70126	ACE2 Polyclonal Antibody	WB,ELISA

SARS-CoV/CoV-2 (2019-nCoV) Proteins

Spike Protein

The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor, and S2 contains basic elements needed for the membrane fusion.

Nucleocapsid Protein (N protein)

The coronavirus N protein is abundantly produced within infected cells. N protein has multiple functions, including binding to viral RNA to form the ribonucleocapsid and has also been proposed to have roles in virus replication, transcription and translation.In host cells, N proteins have been shown to cause deregulation of the cell-cycle, inhibit the production of interferon, up-regulate the production of COX2, up-regulate the activity of AP1, and induce apoptosis in serum deprived cells-of all which may have possible pathological consequences.

Membrane and Unstructural Proteins

Membrane protein and Envelope protein are the key to the efficient assembly of coronavirus.
3C-like proteinase of SARS-CoV-2 virus is a key protein in RNA replication.
Papain-like protease (NSP3) plays an important role in the precursor cleavage of various viral proteins to form a series of functional proteins needed in viral replication.
3C-like proteinase and Papain-like protease are important targets for the development of antiviral drugs, which can inhibit virus replication and reduce related mortality.

ACE2 Protein

ACE2 (Angiotensin Converting Enzyme 2) is the receptor of SARS-CoV-2 infected cells, and the infection process depends on the serine protease TMPRSS2. Blocking the interaction between S protein and ACE2 is an effective way to treat coronavirus infection.