nanoComposix is a world leading manufacturer of precisely engineered and highly characterised nanoparticles.

Their mission is to help our customers bring nanotechnology enabled products to market.

Their multi-disciplinary technical teams provide rapid prototyping, characterisation, integration, and scale-up solutions to accelerate R&D and commercialisation for a wide variety of application areas including biodiagnostics, topical therapeutics, nanomedicine, antimicrobial coatings, and colour engineering.


Product Categories

Products

Gold Nanoparticles

Since 2004, nanoComposix has provided monodisperse and unagglomerated metal and metal-oxide nanomaterials to thousands of customers. Hundreds of different variants of material, size, shape, and surface are available as stock products and we have produced over 2000 custom core/shell, biofunctionalized, fluorescent, and magnetic nanocomposites to meet client specifications.

Nanospheres in Solution
Gold nanospheres in water, ranging from 5–100 nm and a wide variety of surfaces.

Ultra Uniform
Nearly perfect spherical nanoparticles, with smooth surfaces and impressively narrow size distributions (CV < 5-6%).

Nanorods
Surface plasmon resonant (SPR) nanoparticles with tunable aspect ratios, and available at peak resonances from 660–980 nm.

Nanoshells
Surface plasmon resonant (SPR) nanoparticles consisting of a nanoscale silica core surrounded by an ultra-thin gold shell, and available at peak resonances from 660–980 nm.

Lateral Flow
Nanospheres and nanoshells optimized for conjugation and lateral flow applications, especially for assays that require high sensitivity.

Silica Shelled
Silica shells increase stability in a wide range of solvents and provide a versatile conjugation surface.

Dried
Gold nanopowders that are formulated with polymer or alkanethiol surface coatings which allow the nanoparticles to easily be redispersed as unagglomerated dispersions in a variety of solvents.

Organic
Organic solvent-compatible gold nanospheres that disperse uniformly.

Bimetallic
Silver shelled gold nanoparticles with tunable core diameters and shell thicknesses.

Gold Nanoparticle Applications

Gold nanoparticles are one of the most commonly utilized nanomaterials due to their stability and optical properties.

DIAGNOSTIC APPLICATIONS
Gold nanopaticles are readily conjugated to antibodies and other proteins due to the affinity of sulfhydyl (-SH) groups for the gold surface, and gold-biomolecule conjugates have been widely incorporated into diagnostic applications, where their bright red color is used in home and point-of-care tests such as lateral flow assays.

BIOMEDICAL APPLICATIONS:
Gold nanomaterials can be conjugated to biomolecules to specifically target cancer cells, and used for photothermal cancer therapy, where their tunable optical properties cause them to convert laser light into heat and selectively kill cancerous cells.

PLASMONICS
Gold nanoparticles have unique optical properties because they support surface plasmons. At specific wavelengths of light the surface plasmons are driven into resonance and strongly absorb or scatter incident light. This effect is so strong that it allows for individual nanoparticles as small as 30 nm in diameter to be imaged using a conventional dark field microscope. This strong coupling of metal nanostructures with light is the basis for the new field of plasmonics. Applications of plasmonic gold nanoparticles include biomedical labels, sensors, and detectors. The gold plasmon resonance is also the basis for enhanced spectroscopy techniques such as Surface Enhanced Raman Spectroscopy (SERS) and Surface Enhanced Fluoressence Spectroscopy which can be used to detect analytes with ultrahigh sensitivity.

Tutorial Videos

Covalent Gold

UV-Vis Tutorial

Nanoparticle Characterization

Intro to Zeta Potential

Silver Nanoparticles

Since 2004, nanoComposix has provided monodisperse and unagglomerated silver nanoparticles to thousands of customers. Hundreds of different variants of size, shape, and surface are available as stock products and we have produced over 2000 custom core/shell, biofunctionalized, fluorescent, and antimicrobial silver nanocomposites to meet client specifications.

Nanospheres in Solution
Silver nanospheres in water, ranging from 10–200 nm and a wide variety of surfaces.

Silica Shelled
Silica shells increase stability in a wide range of solvents and provide a versatile conjugation surface.

Dried
Silver nanopowders that are formulated with polymer or alkanethiol surface coatings which allow the nanoparticles to easily be redispersed as unagglomerated dispersions in a variety of solvents.

Organic
Organic solvent-compatible silver nanospheres that disperse uniformly.

Nanoplates
Platelet-shaped nanoparticles that have extremely large absorbing and scattering cross-sections in the visible and near-IR regions of the spectrum.

Nanocubes
Silver nanocubes have been used for a broad range of applications including plasmonic sensing, surface enhanced Raman scattering (SERS), metamaterials, catalysis, and bionanotechnology.

Bimetallic
Silver shelled gold nanoparticles with tunable core diameters and shell thicknesses.

Custom
Need a size, shape, surface, or concentration that we don’t offer? Contact us

Silver Nanoparticle Applications

Silver nanoparticles are one of the most commonly utilized nanomaterials due to their anti-microbial properties, high electrical conductivity, and optical properties.

MEDICAL APPLICATIONS
Silver nanopaticles are widely incorporated into wound dressings, and are used as an antiseptic and disinfectant in medical applications and in consumer goods. Silver nanoparticles have a high surface area per unit mass and release a continuous level of silver ions into their environment. The silver ions are bioactive and have broad spectrum antimicrobial properties against a wide range of bacteria. By controlling the size, shape, surface and agglomeration state of the nanoparticles, specific silver ion release profiles can be developed for a given application.

CONDUCTIVE COMPOSITES
Incorporation of silver particles into plastics, composites, and adhesives increases the electrical conductivity of the material. Silver pastes and epoxies are widely utilized in the electronics industries. Silver nanoparticle based inks are used to print flexible electronics and have the advantage that the melting point of the small silver nanoparticles in the ink is reduced by hundreds of degrees compared to bulk silver. When scintered, these silver nanoparticle based inks have excellent conductivity.

PLASMONICS
Silver nanoparticles have unique optical properties because they support surface plasmons. At specific wavelengths of light the surface plasmons are driven into resonance and strongly absorb or scatter incident light. This effect is so strong that it allows for individual nanoparticles as small as 20 nm in diameter to be imaged using a conventional dark field microscope. This strong coupling of metal nanostructures with light is the basis for the new field of plasmonics. Applications of plasmonic silver nanoparticles include biomedical labels, sensors, and detectors. It is also the basis for analysis techniques such as Surface Enhanced Raman Spectroscopy (SERS) and Surface Enhanced Fluorescent Spectroscopy.

PHOTOVOLTAICS
There is increasing interest in utilizing the large scattering and absorption cross sections of plasmonic silver nanoparticles for solar applications. Since the nanoparticles act as efficient optical antennas, very high efficiencies can be obtained when the nanoparticles are incorporated into collectors.

Tutorial Videos

Nanoparticle Characterization

UV-Vis Tutorial

Intro to Zeta Potential

Silica Nanoparticles

Colloidal silica (silicon dioxide) nanoparticles are amorphous materials and are generally spherical in shape. They can be made to have a broad range of sizes and their surface chemistry easily modified to target a variety of applications. Regardless of size, dried silica nanoparticles are a white powder. In their nonporous form, silica nanoparticles are known for being absorbent and abrasive, whereas mesoporous silica nanoparticles have important applications in drug delivery and nanomedicine.

Silica Shelled Gold
Gold nanosphere cores of 20 nm, 50 nm, and 100 nm with 20 nm silica shells to enhance particle robustness and stability in a wide range of solvents.

Silica Shelled Silver
Silver nanospheres and nanoplates of various dimensions with silica shells to enhance particle robustness and stability in a wide range of solvents.

Solid Silica Spheres
Silica nanospheres in water, ranging from 20-1000 nm with silanol or aminated surfaces.

Mesoporous Silica
Mesoporous silica nanoparticles with hexagonal pore structure and 100 nm diameter.

Tutorial Videos

Nanoparticle Characterization

UV-Vis Tutorial

Intro to Zeta Potential

Platinum Nanoparticles

Platinum nanoparticles are used in a variety of applications, including catalysis, Surface Enhanced Raman Spectroscopy and molecular diagnostics. Platinum nanoparticles from nanoComposix have:

  • Diameters of 5, 30, 50 and 70 nm, with guaranteed CVs < 15% (CV < 20% for 5 nm spheres)
  • TEM, UV-Vis, and DLS characterization data provided for every batch
  • A citrate surface and are provided in a citrate buffer

Particle sizes up to 180 nm in diameter and custom surface functionalizations are available upon request.

Select NanoXact for standard 0.05 mg/mL solutions in water or more concentrated BioPure (1.0 mg/mL) for biological applications below.

HELP ME WITH PRODUCT LINES

Product LineDescriptionAvailable MaterialsAvailable SurfacesCVConcentrationAvailable Dried
BioPureSterile & guaranteed endotoxin-freeGold, silver, platinum, magnetiteMultiple< 18%1 mg/mLNo
BioReadyFor bioconjugation (lateral flow assays, etc.)GoldMultiple< 15%Varies; usually 20 ODYes
EconixLowest prices & highest concentrationGold, silverPVP< 25%5 mg/mLYes
NanoXactWidest combination of materials and surfacesGold, silver, silica, platinum, titania, magnetiteMultipleVaries; usually < 15%VariesYes
Ultra UnifromMost monodisperseGoldPEG-carboxyl< 5%0.05 mg/mLNo

HELP ME WITH SURFACES

SurfaceChargeCharacteristicsAvailable Materials
Bare (Citrate)-Easiest standard surface to displace with other molecules.Gold, silver, platinum
Aminated (BPEI)+Covalently bound. Conjugatable surface.Gold, silver
Carbonate-For biocojugation. Smaller, less complex molecule with a lower affinity to gold nanoparticle surface than citrate.Gold
Carboxyl/Lipoic Acid-Covalently bound. Conjugatable surface.Gold, silver
DodecanethiolRedispersible and stable in non-polar organic solvents.Gold, silver
NHSFor quick and easy bioconjugation – no EDC/NHS activation required.Gold
PEGHighest stability in aqueous buffers and polar organic solvents.Gold, silver
PolystyreneHydrophobic surface that allows for dispersion in a wide range of polar organic solvents.Gold
PVP-Large polymer surface. Stable in a wide variety of solvents.Gold, silver, magnetite
Silica Shell-Greatest solvent compatibility. Preserves plasmonic properties upon deposition.Gold, silver, silica
Silica Shell (Aminated)+Conjugatable surface. Greatest solvent compatibility. Preserves plasmonic properties upon deposition.Gold, silver, silica
StreptavidinFor convenient bioconjugation of any biotinylated antibody, protein, or oligonucleotide.Gold
Tannic Acid-Less easily displaced than citrate but stable in more buffers.Gold

Magnetite Nanoparticles

Our magnetite nanoparticles are colloidal iron oxide (Fe3O4) materials that exhibit superparamagnetic properties at ambient temperatures. The particles are surface functionalized with Polyvinylpyrrolidone (PVP) that provides excellent steric stability.

Our standard NanoXact magnetite suspension is provided at a concentration of 20 mg/mL in a 2 mM sodium citrate solution. An extensively purified BioPure solution that is sterile with low endotoxin is available as a 1 mg/mL suspension. A readily dispersible dried suspension is also available.

HELP ME WITH PRODUCT LINES

Product LineDescriptionAvailable MaterialsAvailable SurfacesCVConcentrationAvailable Dried
BioPureSterile & guaranteed endotoxin-freeGold, silver, platinum, magnetiteMultiple< 18%1 mg/mLNo
BioReadyFor bioconjugation (lateral flow assays, etc.)GoldMultiple< 15%Varies; usually 20 ODYes
EconixLowest prices & highest concentrationGold, silverPVP< 25%5 mg/mLYes
NanoXactWidest combination of materials and surfacesGold, silver, silica, platinum, titania, magnetiteMultipleVaries; usually < 15%VariesYes
Ultra UnifromMost monodisperseGoldPEG-carboxyl< 5%0.05 mg/mLNo

HELP ME WITH SURFACES

SurfaceChargeCharacteristicsAvailable Materials
Bare (Citrate)-Easiest standard surface to displace with other molecules.Gold, silver, platinum
Aminated (BPEI)+Covalently bound. Conjugatable surface.Gold, silver
Carbonate-For biocojugation. Smaller, less complex molecule with a lower affinity to gold nanoparticle surface than citrate.Gold
Carboxyl/Lipoic Acid-Covalently bound. Conjugatable surface.Gold, silver
DodecanethiolRedispersible and stable in non-polar organic solvents.Gold, silver
NHSFor quick and easy bioconjugation – no EDC/NHS activation required.Gold
PEGHighest stability in aqueous buffers and polar organic solvents.Gold, silver
PolystyreneHydrophobic surface that allows for dispersion in a wide range of polar organic solvents.Gold
PVP-Large polymer surface. Stable in a wide variety of solvents.Gold, silver, magnetite
Silica Shell-Greatest solvent compatibility. Preserves plasmonic properties upon deposition.Gold, silver, silica
Silica Shell (Aminated)+Conjugatable surface. Greatest solvent compatibility. Preserves plasmonic properties upon deposition.Gold, silver, silica
StreptavidinFor convenient bioconjugation of any biotinylated antibody, protein, or oligonucleotide.Gold
Tannic Acid-Less easily displaced than citrate but stable in more buffers.Gold

Lateral Flow Immunochromatographic Assays

Colloidal Gold for Lateral Flow

Covalent Conjugation Kit
Complete “classroom-in-a-box” with reagents and highly detailed protocols

Citrate Gold
The industry standard, classic surface for passive binding

Carbonate Gold
Alternative, novel “bare” surface for passive binding

Cost

  • As one of the world’s largest gold nanoparticle manufactures, we can leverage our scaled production to produce the highest quality and lowest priced gold colloid for rapid diagnostic tests
  • No commercial use license is required for our gold colloid products – simply purchase and use
  • Contact us for bulk pricing, custom packaging, quality audits, and other commercial support.

Cost

  • As one of the world’s largest gold nanoparticle manufactures, we can leverage our scaled production to produce the highest quality and lowest priced gold colloid for rapid diagnostic tests
  • No commercial use license is required for our gold colloid products – simply purchase and use
  • Contact us for bulk pricing, custom packaging, quality audits, and other commercial support.

Support

  • Dedicated technical support personnel to answer your questions
  • Ability to bring assay development in-house
  • Proven record with customers

Gold Nanoshells for Maximizing Visual Detection Sensitivity

High Sensitivity Conjugation Kit
Complete “classroom-in-a-box” with reagents and highly detailed protocols ❯

Carboxyl Gold Nanoshells
Robust and reliable covalent conjugations

NHS Gold Nanoshells (Dried)
Amine-reactive gold nanoshells for quick conjugations

Streptavidin Gold Nanoshells
For binding to biotinylated targets

The Nanoshell Advantage

Ultra-bright gold nanoshells provide up to a 20× increase in lateral flow diagnostic sensitivity over 40 nm gold nanoparticles. Combining the benefits of gold nanoshell brightness and covalent conjugate stability, gold nanoshells are recommended for achieving maximum assay sensitivity.

Gold nanoshells consist of a 120 nm silica core coated with a 15 nm thick gold shell. Due to the plasmon resonance of the gold nanoshells, an intense blue line will be visible on white lateral flow test strips.

Lateral Flow Assay Development

Why Choose nanoComposix?

  • Quality: Regulatory compliance under ISO13485
  • Scientific rigor: 30 years combined experience of experts in the manufacturing and optimization of colloidal gold, gold reagents, and robust, reproducible conjugates
  • Competitive Advantage: Gold Nanoshells offer the most sensitive quantitative and semi-quantitative visual detection available, eliminating the need for costly filters and lenses
  • Flexibility: Full contract lateral flow assay development from feasibility to manufacturing or flexibility to assist with any Phase in your development cycle
  • Supply Chain: On-site bulk manufacturing of colloidal gold and Gold Nanoshells to accommodate large scale manufacturing of strips and conjugates

Our Process

Our scientists understand that each assay being developed is unique with specific requirements, therefore, without knowing more about the test in question, only general development deliverables and associated pricing can be provided.

Case Studies

Development of food safety assay using novel nanoparticles
Case Study: Fortune 500 packaging company

The existing standard method of detection for this food safety assay requires multiple days and a skilled scientist to perform the test. Using ultra-sensitive nanoparticle technologies, nanoComposix is developing a rapid lateral flow assay that can identify dangerous bacterial pathogens in less than 10 minutes.

Manufacture of validation lots of full rapid test kits under ISO13485 quality system
Case Study: Non-profit organization developing assays for detection of neglected tropical diseases

Using the gold nanoshells, the non-profit group was able to achieve the desired sensitivity for their assay. The assay was transferred to nanoComposix for transfer to scale-up manufacturing under our ISO13485 compliant quality system. The assays were manufactured (50K strips) for testing in third world countries and are currently being evaluated in the field.

Novel particles used for assay development, helped reach the limit of detection
Case Study: Market leader in veterinary diagnostics

This customer turned to nanoComposix after three years of assay development where assay sensitivity could not be achieved by an internal team or with two separate contract assay development manufactures. The first company spent 6-months optimizing the assay and could not reach the required limit of detection. The second development company used proprietary nanobeads which achieved sensitivity but dried conjugate was unstable after 6 weeks. After a one-month effort, nanoComposix achieved the clinically relevant sensitivity using gold nanoshells.

Product Lines

BioPure: Purified & Sterile Nanoparticles

BioPure nanoparticles are unagglomerated and highly characterized nanoparticles that are tailored for use in biological assays. BioPure particles have the following advantages:

  • Extensively washed to remove residual reactants
  • Guaranteed sterile and endotoxin-free
  • Highly concentrated

We make over 120 different variants of BioPure nanoparticles.

Product LineDescriptionAvailable MaterialsAvailable SurfacesCVConcentrationAvailable Dried
BioPureSterile & guaranteed endotoxin-freeGold, silver, platinum, magnetiteMultiple< 18%1 mg/mLNo

BioReady: Conjugation-Ready Nanoparticles

BioReady nanoparticles are optimized for binding biomolecules to the nanoparticle surface. The nanoparticle conjugates are used in rapid diagnostic testing and sensing applications such as lateral flow immunoassays. To make a reporter particle selection follow these guidelines:

  • For the highest sensitivity in rapid diagnostic tests use 150 nm carboxyl gold nanoshells for covalent binding to proteins.
  • If you just need the increased stability, reduced antibody costs, higher sample matrix stability, and more reproducible conjugates provided by covalent binding chemistry use 40 nm or 80 nm carboxyl gold nanoparticles
  • If you are looking for increased sensitivity for passive conjugates, try our “bare” carbonate nanoparticles.

We always recommend starting with our covalent conjugation kits since they include all of the components necessary for rapid success.

Product LineDescriptionAvailable MaterialsAvailable SurfacesCVConcentrationAvailable Dried
BioReadyFor bioconjugation (lateral flow assays, etc.)GoldMultiple< 15%Varies; usually 20 ODYes

Econix: Industrial Grade Nanoparticles

Econix gold and silver nanoparticles are industrial grade nanomaterials that have a price per mg that is up to 100 times lower than other product lines at nanoComposix. Econix particles have the same high quality and extensive characterization as all of nanoComposix’s products. The only difference is that the selection of sizes and surfaces is more limited and the nanoparticles have a broader size distribution.

  • Econix gold is available with a PVP surface with diameters of 15 nm, 50 nm and 75 nm in both water (5 mg/mL) and dried.
  • Econix silver is available with a PVP surface with diameters of 5 nm, 25 nm, 50 nm, 75 nm and 110 nm in both water (5 mg/mL) and dried.

All gold and silver Econix variants are available below.

Product LineDescriptionAvailable MaterialsAvailable SurfacesCVConcentrationAvailable Dried
EconixLowest prices & highest concentrationGold, silverPVP< 25%5 mg/mLYes

NanoXact Nanoparticles

NanoXact is our original product brand and has the widest selection of materials and surface types. The benefits of NanoXact are:

  • High purity and aggregation-free
  • Extensive characterization sheet including TEM, UV-Vis, and DLS for each lot
  • Size ranges from 5–1000 nm with CVs typically less than 15%
  • Available with a wide variety of surfaces.

We make over 150 different variants of NanoXact nanoparticles.

Product LineDescriptionAvailable MaterialsAvailable SurfacesCVConcentrationAvailable Dried
NanoXactWidest combination of materials and surfacesGold, silver, silica, platinum, titania, magnetiteMultipleVaries; usually < 15%VariesYes

Ultra Uniform: Highly Monodisperse Nanoparticles

For applications requiring the highest uniformity in size and shape, our Ultra Uniform gold nanoparticles have a nearly perfect spherical shape, smooth surfaces, and impressively narrow size distributions (CV < 5%). The particles are used as reference standards for size and number, for TEM calibration and as biological labels.

The particles are available in diameters of 10, 30, 50 and 100 nm and are provided at a concentration of 0.05 mg/mL in a 2 mM sodium citrate solution.

Product LineDescriptionAvailable MaterialsAvailable SurfacesCVConcentrationAvailable Dried
Ultra UniformMost monodisperseGoldPEG-carboxyl< 5%0.05 mg/mLNo

Product Information

Dream, Design, Deliver

Our in-stock products are only a small fraction of what we can build.
Over the last 10 years we’ve produced thousands of custom nanoparticle formulations for our customers.


Understand

State of the art analysis of nanoparticles with
NIST traceable calibration and ISO13485/cGMP analysis methods.


Convert Promise into Reality

We work closely with our clients to build prototypes that meet their functional specifications.


Scale It

Our ISO13485/cGMP compliant quality management system produces highly reproducible nanoparticle formulations for biodiagnostic, nanomedicine, photonics and consumer applications.


Precisely Engineered Nanomaterials

Use our library of over 500 in-stock nanoparticle variants to accelerate your research projects.

FAQs

I can’t find the material or size that I’m looking for. Can you make it for me?

We routinely fabricate custom materials for our customers. Please see our custom synthesis page for more information.

Can you coat nanomaterials with other capping agents or biomolecules?

We routinely functionalize our materials with alternative capping agents or biomolecules for our customers. Please see our custom synthesis page for more information.

How are your materials characterized?

All of our nanomaterials are provided with specification sheets that include TEM images, particle size statistics and histogram based on 100 individual nanoparticle measurements, UV-Visible extinction spectrum and pH. Hydrodynamic diameter (dynamic light scattering) and zeta potential are also measured for spherical nanoparticles > 10 nm.


Rapid Test Kits Development

Request a QuoteTechnical SupportPlace an Order Below is a selection of reagents for the development of COVID-19 rapid test kits. Read More...

nanocomposix covid-19

Research Solutions for Coronavirus – Nanocomposix

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Useful Terminology

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Plasmonics

Plasmonic Nanoparticles Plasmonic metal nanoparticles – including gold, silver, and platinum – are highly efficient at absorbing and scattering light.  By changing Read More…

Contract R&D and Manufacturing

NanoComposix is a world leader in nanomaterial research and development, manufacturing, and processing. Since 2004, we have developed innovative solutions Read More…

Color Engineering

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Custom Synthesis

A very small sampling of the many custom products nanoComposix has made over the years. NanoComposix has a multi-disciplinary team Read More…

Depositing Monolayers and Thin Films of Nanoparticles

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Frequently Asked Questions

Nanocomposix FAQs

Most Common I can’t find the material or size that I’m looking for. Can you make it for me? We Read More…