Significance of TG Control
The significance of triglyceride (TG) controls has been shown in recent studies. Development of new drugs that inhibit regulating factors of LPL activity that are critical for TG metabolism has been progressing on a fast track.
Future Drug Development (ANGPTL3, 4, 8 and ApoC3 inhibitors)
The factors that negatively regulate LPL activity like ANGPTL3 inhibitor and recent hot topics “The Development of ApoC3 Inhibitor” have been actively discussed by researchers. It has been expected that the most focused drug development might be ANGPTL4 inhibitor and/or ANGPTL8 inhibitor in the near future.
Another Risk Factor as Drug Development Target (ApoA5 and GPIHBP1)
It has been considered that possible risk factors that positively regulate LPL activity like ApoA5 or GPIHBP1 might be targeted in drug development for the purpose of TG controls. Furthermore, it has been suggested that ApoA5 could be an important risk factor for early-onset myocardial infarction as well as LDL receptor by genome analysis.
ANGPTL2 associates with Cardiac Dysfunction
It is recently reported that there may be evidence of correlation between elevated circulating ANGPTL2 levels and cardiovascular disease (CVD) or heart failure (HF) as well as association between ANGPTL2 expression and cellular senescence.
h: Human m: Mouse r: Rat m/r: Mouse / Rat hmr: Human / Mouse / Rat h.s.: High-Sensitive FL: Full-Length