SBI is a small biotech company that’s delivered innovative products and services for molecular and cell biology research since January 2004, when they sold their first lentivectors and pPACK lentivirus packaging systems.

They focus on being the first company to bring the most recent methodologies to market—they were the first company to deliver exosome research reagents and CRISPR/Cas9 vectors—so researchers could quickly take advantage of the latest, most powerful approaches.

Dedicated to quality, many of their products and most of their service offerings are completed in their state-of-the-art facility in Palo Alto CA, enabling them to maintain control over manufacturing conditions and quality, ensure their service projects remain confidential and deliver frequent and timely service project status updates.

Their experienced staff includes a high proportion of PhD-level scientists who interact directly with customers to provide product and services support.

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Lentiviral Technology

  • Expression Vectors
  • Cumate Inducible Vectors
  • Transcription Reporter Vectors
  • Virus Production
  • Reporter Cell Lines


  • AAV Isolation
  • AAV Vectors

Genome Engineering

  • PrecisionX™ Cas9 SmartNuclease and SmartNickase Vectors
  • Multiplex gRNA CRISPR/Cas9 kits
  • HR Targeting Vectors
  • AAVS1 Safe Harbor Targeting
  • EZ-Genotyping Kit
  • phiC31 Integrase System
  • PinPoint Targeting System
  • PiggyBac Transposon

Molecular Tools

  • Cold Fusion cloning
  • MetaMorph Mutagenesis Kit
  • mRNAExpress RNA Synthesis Kit
  • PureFection transfection
  • Retrovirus concentration
  • Cyto-Tracers
  • Molecular Imaging Vectors
  • MycoQuick
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LncRNA Research


Gene Analysis

  • RNA-Quant cDNA Synthesis
  • FullSpectrum
  • MultiStart Primers
  • Interferon Response Detection Kit


RNAi Libraries

  •  Application Overview
  • Human Genome-wide
  • Mouse Genome-wide
  • Pathway Focused


Immunology Research

  •  Foxp3 vectors
  • RORyt vectors
  • T cell Reporter



We won’t be

beaten on


Episomal Vector Technologies

Stem Cell Research

  • Growth Factors and Media
  • iPSC Reprogramming Systems
  • Antibody and AP Staining Kits
  • iPS Cell Lines
  • Pluripotency Reporters
  • Differentiation Reporters
  • Neural Lineage qPCR Profiler

Exosome Research

  • Exosome Isolation
  • Purified Exosomes
  • Transfect Exosomes
  • EV Shuttle Kits
  • EV-Entry Reagent
  • Label Exosome Cargo (red, green)
  • Package miRNAs into Exosomes
  • Load Protein Cargo
  •  Targeting Technology
  • Immunopurify Exosomes
  • Exosome-depleted FBS
  • Exosome Antibodies
  • Exosome Quantitation
  • RNA-Seq and Mass Spec
  • Profile Exosome microRNAs

MicroRNA Research

  • Expression Profiling: QuantiMir, OncoMir, Stem Cell Collection, miRNome
  • MicroRNA Overexpression
  • Bi-allelic MicroRNA Knockout
  • MicroRNA Knockdown
  • MicroRNA Virus Libraries




  • Custom Constructs
  • Virus Packaging Service
  • Custom Reporter Cell Lines
  • Custom RNAi Libraries
  • Hybridization & Data Analysis for RNAi Libraries
  • Scientific Consulting

Stem Cell

  • Custom iPS Cell Lines

Genome Engineering

  • CRISPR/Cas9 SmartNucleases
  • HR Donor Vectors
  • Design Services


  • Profiling Overview
  • Genome-wide
  • OncoMir Collection
  • Stem Cell Collection
  • Precursor Overexpression
  • MicroRNA Knockdown
  • Scientific Consulting


System Biosciences (SBI) specialises in developing unique, innovative technologies to provide researchers with the tools to investigate and understand genomic and proteomic function.  SBI offers solutions for lentiviral mediated gene delivery and knockdown, high-throughput RNAi screens and products for Stem Cell and MicroRNA research.

SBI’s extended set of cloning and expression lentivectors provide efficient delivery of expression constructs in mammalian systems.  To achieve highly efficient delivery and stable expression, the lentiviral constructs can be packaged in VSV-G pseudoviral particles and transduced into a wide range of cell lines or to model organisms (mouse, rat, etc.).

GeneNet™ shRNA Libraries enable you to perform high-throughput gene knockdown studies on a genome-wide or pathway-focused basis. You can simultaneously identify multiple genes that alter a specific cellular phenotype in a single experiment.

SBI’s range of products for stem cell research include induced Pluripotency Stem Cell (iPSC) Factor Constructs, Human and Mouse iPS cell lines, transcriptional reporters for confirmation of pluripotency and tools for tracking stem cell, differentiation.  In addition, SBI has developed innovative technologies and tools for qPCR Expression profiling, cloning, overexpression and knockdown of microRNAs to enhance your research discoveries.

System Biosciences continues to create new and unique products as well as improve our well-established product lines. Our commitment to providing leading-edge technologies is matched by our high quality of manufacturing and quality control for all of our research reagents and research project services.



Simultaneous Detection of cfDNA and Exosomal Biomarkers

Expanding biomarker research capabilities Accelerate and enhance your biomarker discovery and characterization studies with the XCF™ COMPLETE Exosome & cfDNA Read More…


Genome Engineering Tools from Novabiotein Cas9 (CRISPR associated protein 9) is an RNA-guided DNA endonuclease enzyme associated with the CRISPR Read More…

Stem Cell

Frequently Asked Questions (FAQs) Q: What method of reprogramming source cells is the most efficient? A: The retroviral method of Read More…


Frequently Asked Questions (FAQs) MicroRNA profiling Q: How should I prepare or purify my RNA prior to QuantiMir cDNA synthesis? Read More…


ExoQuick Frequently Asked Questions (FAQs) Q: How do I decide which ExoQuick product to start with? ExoQuick or ExoQuick-TC?? A: Read More…

Exosomes Explained

How to use Exosomes

Exosomes Tools, from isolation to engineering Exosomes – extracellular vesicles (EVs) 30 – 200 nm in size were once thought Read More…

How Lentivirus Delivery Works

The pseudoviral particles can infect target cells and express genes, shRNAs, microRNAs and reporter molecules but cannot replicate within the Read More…

Exo-Fect™ Exosome Transfection

Exo-Fect is a novel nucleic acid transfer agent that enables the transfection of nucleic acids directly into isolated exosomes. The Read More…

PinPoint Targeted Integration System

The PinPoint Targeted Integration system allows users to easily and efficiently create isogenic stable cell lines in mammalian and other Read More…

Minicircle DNA Vector Technology

The Minicircle advantage Minicircles are episomal DNA vectors that are produced as circular expression cassettes devoid of any bacterial plasmid Read More…

PureFection™ Transfection Reagent

  PureFection™ Nanotechnology-based Transfection Reagent Deliver more DNA and siRNAs to cells than the leading lipid-based transfection kits PureFection is Read More…

Exosome Research Tools

  Comprehensive Toolset ExoQuick Isolation Exo-FBS media Antibodies and ELISAs Exo-RNA Purification Exo-RNA Next-Gen Sequencing Why are exosomes important? Once Read More…

MicroRNA Research

  Everything you need for microRNA research Integrated solutions for microRNA analysis SBI has developed innovative technologies and tools for Read More…

Cold Fusion Cloning Kit

The Cold Fusion technology is a simple, rapid and highly efficient cloning kit. It allows you to directly clone any Read More…

Exosome Antibodies, Arrays and ELISA Kits Detect and quantitate isolated exosomes

  Track and Quantitate Exosomes with Antibodies and ELISAs Exosomes are small membrane vesicles secreted by most cell types in Read More…

Sample Preperation

Overview Good sample preparation is arguably the most critical step in any analytical process because most techniques are unable to Read More…

Analysis of PCR

Overview Analysing and visualising your results is often the culmination of weeks if not months of work and can be Read More…

Genetic Engineering – Master the Essentials

Overview In Molecular Biology, the ability to successfully manipulate DNA is essential.  Stratech offers cutting edge cloning systems, genome editing Read More…


  Overview There are many ways of visualising your results; some of them more visual than others! Stratech supply sensitive Read More…

phiC31 Integrase Vector System One-step Gene Addition Technology

NEW from System Biosciences (SBI) the phiC31 Integrase Cloning system for mammalian genome engineering applications. This system provides the researcher Read More…