SignalChem Lifesciences Corporation (“SLC”), headquartered in British Columbia, Canada, is a clinical-stage company developing novel targeted therapies for oncology.

Its unique business model has been built upon two important pillars: the Bioreagents and Research Services business and the Drug Discovery and Development business.

A group of scientists with extraordinary expertise and experience in kinase biology and drug discovery are working together cohesively to provide the best products and services to its customers around the world and to maximize the efficiency of its own drug discovery efforts.

Built on its expertise in developing kinase-focused cell signalling products and delivering discovery services for academia and pharmaceutical industry, SignalChem has uniquely positioned itself in the forefront of kinase inhibitor drug discovery.

Its advantages include, but not limited to, the largest and ever-growing repertoire of active kinases and mutant kinases, optimised activity-based assays on multiple assay platforms, broad interactions and partnership with leading pharmaceutical companies.

Product Categories


  • Active Acetyltransferases
  • Active Arginine Deiminases
  • Active GTPases/ATPases
  • Active Histone Deacetylases
  • Active Kinase Mutants
  • Active Kinases
  • Active Lipid Kinases
  • Active Methyltransferases
  • Active Phosphatases
  • Active Phosphodiesterases
  • Active Proteases


  • Isoform Specific Antibodies
  • Modification Antibodies
  • Phospho Specific Antibodies
  • Primary Antibodies
  • Secondary Antibodies
  • Tag Antibodies

Biochemical Compounds

  • Epigenetic Enzyme Activators
  • Epigenetic Enzyme Inhibitors
  • Kinase Activators
  • Kinase Inhibitors
  • Phosphatase Inhibitors
  • siRNA Controls
  • siRNA Sets

Signaling Proteins

  • Acetyl/Methyltransferases
  • Adaptor Proteins
  • Apoptosis Proteins
  • Arginine Deiminases
  • Cell Cycle Proteins
  • Cell Stress & Chaperone Proteins
  • Cellular Proteins
  • Deacetylase/Demethylases
  • Dihydropyrimidinase
  • Dioxygenases
  • Fructose Kinases
  • G-Proteins
  • Kinase Mutant Proteins
  • Kinase Protein
  • Lysyl Oxidases
  • Microtubule/Actin
  • Associated Proteins
  • Phospholipase C Proteins
  • Superoxide Dismutase
  • Tau Proteins
  • Transcription Proteins
  • Ubiquitin Proteins
  • Unactive Kinases

Signalling Reagents

  • Assay Reagents
  • Lipid Substrates
  • Oligo Substrates
  • Peptide Substrates
  • Protein Substrates

Extracellular Ligands

  • Chemokines
  • Cytokines
  • Growth Factors

Research Areas

SignalChem’s product selection is available in the following areas of relevance for signalling proteins:

  • Akt / PKB Pathway
  • Apoptosis
  • Cancer
  • Cardiovascular Disease
  • Cell Cycle
  • Cellular Stress
  • Cytoskeletal Signaling
  • Death Receptor Signaling
  • Diabetes
  • DNA Damage
  • GPCR Pathway
  • Growth Factor Signalling
  • Heat Shock Signalling
  • Inflammation
  • Insulin Receptor Signalling
  • JAK-STAT Pathway
  • Lipid Signalling
  • MAPK / ERK Pathway
  • Neurobiology
  • NF-kB Pathway
  • p38 Pathway
  • PKC Signalling
  • SAPK/JNK Pathway
  • Ser / Thr Kinases
  • T & B Cell Receptor Signalling
  • Translational Control
  • Tyr Kinases
  • Wnt Signalling

SignalChem is a biotechnology company focused on the research, development and production of innovative cell signaling products to advance basic research and drug discovery efforts, with specific emphasis on the production of highly purified, biologically active, human recombinant proteins.

Cellular signalling or the mechanism by which a cell transmits its signals inwards, ultimately producing a specific biological response, is of fundamental clinical importance.  It is well documented that aberrations in these discrete pathways have been linked to the development of a variety of human diseases including cancer, cardiovascular disease, metabolic disorders, neurodegenerative disease and inflammatory conditions amongst others.

With the success of signal transduction inhibitors in the clinic, there is an intensive effort to identify targets linked with the pathogenesis of a human disease and to develop selective molecules to perturb these targets in an effort to improve patient prognosis and minimise the non-specific systemic side-effects associated with generalised treatment modalities.

The founders and scientific members of SignalChem have the knowledge to understand the architecture and biology of these discrete signalling pathways and to leverage this expertise to bring value-added products to the market.  SignalChem is emerging as a leader and a key contender in the life science recombinant protein market place.

SignalChem’s core product areas include active human protein kinases, active human protein phosphatases, unactive signalling proteins, assay kits and biologically relevant kinase and phosphatase substrates.

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