SignalChem Lifesciences Corporation (“SLC”), headquartered in British Columbia, Canada, is a clinical-stage company developing novel targeted therapies for oncology.

Its unique business model has been built upon two important pillars: the Bioreagents and Research Services business and the Drug Discovery and Development business.

A group of scientists with extraordinary expertise and experience in kinase biology and drug discovery are working together cohesively to provide the best products and services to its customers around the world and to maximize the efficiency of its own drug discovery efforts.

Built on its expertise in developing kinase-focused cell signalling products and delivering discovery services for academia and pharmaceutical industry, SignalChem has uniquely positioned itself in the forefront of kinase inhibitor drug discovery.

Its advantages include, but not limited to, the largest and ever-growing repertoire of active kinases and mutant kinases, optimised activity-based assays on multiple assay platforms, broad interactions and partnership with leading pharmaceutical companies.


Product Categories

Research Areas

SignalChem’s product selection is available in the following areas of relevance for signalling proteins:

  • Akt / PKB Pathway
  • Apoptosis
  • Cancer
  • Cardiovascular Disease
  • Cell Cycle
  • Cellular Stress
  • Cytoskeletal Signaling
  • Death Receptor Signaling
  • Diabetes
  • DNA Damage
  • GPCR Pathway
  • Growth Factor Signalling
  • Heat Shock Signalling
  • Inflammation
  • Insulin Receptor Signalling
  • JAK-STAT Pathway
  • Lipid Signalling
  • MAPK / ERK Pathway
  • Neurobiology
  • NF-kB Pathway
  • p38 Pathway
  • PKC Signalling
  • SAPK/JNK Pathway
  • Ser / Thr Kinases
  • T & B Cell Receptor Signalling
  • Translational Control
  • Tyr Kinases
  • Wnt Signalling

SignalChem is a biotechnology company focused on the research, development and production of innovative cell signaling products to advance basic research and drug discovery efforts, with specific emphasis on the production of highly purified, biologically active, human recombinant proteins.

Cellular signalling or the mechanism by which a cell transmits its signals inwards, ultimately producing a specific biological response, is of fundamental clinical importance.  It is well documented that aberrations in these discrete pathways have been linked to the development of a variety of human diseases including cancer, cardiovascular disease, metabolic disorders, neurodegenerative disease and inflammatory conditions amongst others.

With the success of signal transduction inhibitors in the clinic, there is an intensive effort to identify targets linked with the pathogenesis of a human disease and to develop selective molecules to perturb these targets in an effort to improve patient prognosis and minimise the non-specific systemic side-effects associated with generalised treatment modalities.

The founders and scientific members of SignalChem have the knowledge to understand the architecture and biology of these discrete signalling pathways and to leverage this expertise to bring value-added products to the market.  SignalChem is emerging as a leader and a key contender in the life science recombinant protein market place.

SignalChem’s core product areas include active human protein kinases, active human protein phosphatases, unactive signalling proteins, assay kits and biologically relevant kinase and phosphatase substrates.

Protein Kinases are a family of pivotal enzymes with 518 members implicated in various cell signaling pathways, constituting over 2% of the human genome. Kinases exert their roles by phosphorylating their respective physiological substrates. They catalyze the transfer of γ-phosphate from ATP or GTP to the hydroxyl groups of serine, threonine and tyrosine residues on the substrate proteins or the glycosyl moieties in lipids. Deregulation of Kinase could lead to the changes in enzymatic activity and/or expression, subcellular localization, the stability of kinase, protein-protein interactions. Aberrant regulation of Kinase-mediated signaling pathways is responsible for all major human pathological conditions such as cancer, cardiovascular disease, neurodegenerative diseases and metabolic disorders.

SignalChem offers a broad range of recombinant protein and lipid Kinases of superior purity and activity to assist the global academic research and drug discovery efforts with the focus on Kinases. Its active Kinase product line is one of the most comprehensive in the world in terms of the coverage and has been utilized by many pharmaceutical companies in their drug discovery programs. An in-house product development team with over 100 years of combined experience in Kinase biochemistry is behind the production and quality control of all the Kinase-related products as well as assay development.

Protein phosphorylation is a reversible post-translational modification carried out by two families of enzymes, Protein Kinases and Protein Phosphatases. The interplay between these two families of enzymes is responsible for modulating the phosphorylation state of their physiological substrates, and thereby their activities, subcellular localization and interactions with other proteins. Similar to Protein Kinases, Protein Phosphatases play pivotal roles in a myriad of biological processes including cell growth, proliferation, survival, and apoptosis. Protein Phosphatases are broadly categorized according to specific amino acids they dephosphorylate into two major families: protein serine/threonine phosphatases, and protein tyrosine phosphatases, which also include the dual-specificity phosphatases.

SignalChem, with comprehensive active Protein Kinase product line, has utilized our expertise in the recombinant protein production to manufacture biologically active phosphatases including PP1s, PP2s, PTPNs, and more. An in-house product development team with over 100 years of combined experience in protein biochemistry is behind the production and quality control of all the phosphatases as well as the method development for their activity assays. We aim to manufacture our phosphatases with superior quality and activity to facilitate and assist the global research and drug discovery efforts aiding human health.

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
CDC25A, ActiveC04-20GHumanGSTSf9 insect cells using baculovirusFull LengthNM_001789
CDC25B, ActiveC04-20BGHumanGSTSf9 insect cells using baculovirusFull LengthNM_021873
CDC25C, ActiveC04-20CGHumanGSTSf9 insect cells using baculovirusFull LengthBC019089
DUSP22 (MKPX), ActiveD22-20GHumanGSTE.coliFull LengthNM_020185
PP1A, ActiveP13-20GHumanGSTSf9 insect cells using baculovirusFull LengthNM_002708
PP1A, ActiveP13-20GHHumanGSTE.coliFull lengthNM_002708
PP1B, ActiveP14-20GHumanGSTSf9 insect cells using baculovirusFull LengthNM_002709
PP2A alpha/PPP2R1A Complex, ActiveP16-20BHHumanHISSf9 insect cells using baculovirusFull LengthNM_002715
PP2Aα/PPP2R1A Complex, ActiveP16-20BGHumanGSTSf9 insect cells using baculovirusFull lengthNM_002715
PP2Calpha, ActiveP02-20GHumanGSTSf9 insect cells using baculovirusFull LengthNM_021003
PP2Calpha, ActiveP02-20BGHumanGSTE.coliFull LengthNM_021003
PP2Cgamma, ActiveP07-20GHumanGSTSf9 insect cells using baculovirusFull LengthNM_177983
PTEN, ActiveP23-20GHumanGSTE.coliFull LengthNM_000314
PTEN, ActiveT03-20HHumanHISSf9 insect cells using baculovirusFull lengthNM_000314
PTPN1 (PTP1B), ActiveP28-20GHumanGSTSf9 insect cells using baculovirusFull LengthNM_002827
PTPN11 (SHP2), ActiveP38-21GHumanGSTE.coli246-593NM_002834
PTPN11 (SHP2), ActiveP38-20GHumanGSTSf9 insect cells using baculovirusFull LengthNM_002834
PTPN11 (T253M Q257L), ActiveP38-22GHumanGSTSf9 insect cells using baculovirusFull LengthNM_002834
PTPN12 (PTP-PEST), ActiveP39-21GHumanGSTE.coli1-355NM_002835
PTPN13 (FAP-1), ActiveP40-21GHumanGSTE.coli2169-2485NM_080683
PTPN2 (TC-PTP), ActiveP29-20GHumanGSTE.coliFull LengthNM_080422
PTPN6 (SHP1), ActiveP33-20GHumanGSTE.coliFull LengthNM_080548
PTPN6 (SHP1), ActiveP33-20HHumanHISE.coliFull LengthNM_0080548
PTPN7 (LC-PTP), ActiveP34-20GHumanGSTE.coliFull LengthNM_002832
PTPRA (LRP), ActiveP48-21GHumanGSTE.coli174-802NM_002836
PTPRB, ActiveP49-21GHumanGSTSf9 insect cells using baculovirus1552-endNM_002837
PTPRC (CD45), ActiveP50-21HHumanHISSf9 insect cells using baculovirus604-endNM_002838
PTPRC (CD45), ActiveP50-21BGMouseGSTE.coli592-endNM_001111316
PTPRE, ActiveP52-21GHumanGSTSf9 insect cells using baculovirus75-endBC050062
PTPRF (LAR), ActiveP53-21GHumanGSTE.coli1275-1897NM_002840
PTPRJ (CD148), ActiveP56-21GHumanGSTSf9 insect cells using baculovirusFull LengthNM_002843
PTPRS (PTP- sigma), ActiveP64-21GHumanGSTE.coli883-1210NM_130855
SHIP1, ActiveP08-20GHumanGSTSf9 insect cells using baculovirusFull LengthNM_005541
SHIP2, ActiveP09-20GHumanGSTSf9 insect cells using baculovirusFull LengthNM_001567
WIP1, ActiveP04-20GHumanGSTSf9 insect cells using baculovirusFull lengthBC016480

Epigenetic enzymes are crucial in maintaining key cellular functions by modifying chromatin structures and controlling gene transcription process. These reversible epigenetic DNA and histone modifications are controlled by important epigenetic enzymes such as methyltransferases and acetyltransferases. Dysregulation of these enzymes have been observed in myriad human diseases such as cancer. In recent years, epigenetic enzymes have emerged as some of the most promising classes of targets for drug discovery projects and development projects.

Scientists at SignalChem have developed a full range of epigenetic enzymes including acetyltransferases, histone deacetylases, methyltransferases and more. Our high-quality recombinant epigenetic enzymes and the assay methods are valuable tools for scientists to conduct research in epigenetics and for the pharmaceutical companies to develop novel therapeutics modulating these biological targets.

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
ASH2L ProteinA372-30BGHumanGSTE.coliFull LengthBC015936
BRD3 ProteinB17-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_007371
DNMT1 ProteinD351-31GMouseGSTSf9 insect cells using baculovirus766-endBC053047
DPY30 ProteinD369-30HHumanHISE.coliFull LengthNM_032574
EED ProteinE310-30HHumanHISE.coliFull LengthBC068995
EZH1 ProteinE395-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC015882
EZH2 (Y641C) ProteinE396-32BGHumanGSTSf9 insect cells using baculovirusFull LengthBC010858
EZH2 (Y641H) ProteinE396-32DGHumanGSTSf9 insect cells using baculovirusFull LengthBC010858
EZH2 (Y641N) ProteinE396-32EGHumanGSTSf9 insect cells using baculovirusFull-LengthBC010858
EZH2 (Y641S) ProteinE396-32FGHumanGSTSf9 insect cells using baculovirusFull-LengthBC010858
EZH2 ProteinE396-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC010858
HEMK1 ProteinH311-30GHumanGSTSf9 insect cells using baculovirusFull-LengthNM_016173
KAT3A (CREBBP) ProteinK312-31GHumanGSTSf9 insect cells using baculovirus518-1207NM_004380
KAT3B (EP300) ProteinK312-31BGHumanGSTSf9 insect cells using baculovirus532-1153; contains the catalytic domainNM_001429
KAT4 ProteinK313-31GHumanGSTSf9 insect cells using baculovirus1032-endNM_138923
KAT8 (MYST1) ProteinK317-31GHumanGSTSf9 insect cells using baculovirus2-467BC037773
KAT9 (ELP3) ProteinK318-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_018091
LCMT2 ProteinL322-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_014793
MEP50 (WDR77) ProteinW329-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC001679
METTL1 ProteinM321-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_005371
METTL11A ProteinM331-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC001396
METTL14 ProteinM334-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_020961
METTL2A ProteinM322-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_181725
METTL3 ProteinM323-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_019852
MGMT ProteinM354-30HHumanHISSf9 insect cells using baculovirusFull LengthBC000824
P300 ProteinP07-31GHumanGSTSf9 insect cells using baculovirus1283-1673NM_001429
PCAF ProteinP09-31GHumanGSTE.coli431-endNM_003884
PCMT1 ProteinP314-30GHumanGSTSf9 insect cells using baculovirus2-endBC007501
PCNA ProteinP11-30HHumanHISE.coliFull LengthNM_002592
PRDM2 (KMT8) ProteinP333-31GHumanGSTSf9 insect cells using baculovirus1-340NM_012231
PRMT2 ProteinP365-30BGHumanGSTSf9 insect cells using baculovirusFull LengthBC000727
PRMT5 ProteinP365-30EGHumanGSTSf9 insect cells using baculovirusFull LengthNM_006109
PRMT7 ProteinP365-30GGHumanGSTSf9 insect cells using baculovirusFull LengthBC000146
RBBP4 ProteinR314-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC075836
RBBP5 ProteinR315-30HHumanHISE.coliFull LengthNM_005057
SETD4 ProteinS353-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC002898
SETD8 ProteinS345-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC050346
SETDB1 (KMT1E) ProteinS346-31GHumanGSTSf9 insect cells using baculovirus715-endBC028671
SETDB2 ProteinS346-30BGHumanGSTSf9 insect cells using baculovirusFull LengthBC047434
SETMAR ProteinS347-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC011635
TRDMT1 (DNMT2) ProteinT352-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC047733
WDR5 ProteinW325-30HHumanHISE.coliFull LengthBC001635
WHSC1L1 (NSD3) ProteinN378-31GHumanGSTSf9 insect cells using baculovirus1038-endBC113469
WTAP ProteinW369-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_004906

Protein modifications by ubiquitin (Ub) or ubiquitin-like proteins (UBLs) participate in many critical cellular processes such as cell-cycle regulation, DNA repair, oncogenesis, antiviral pathways and most notably, proteasomal degradation of target proteins. Ubiquitination and modification by UBLs share a similar catalytic cascade which requires the sequential action of three classes of enzymes: E1 activating enzymes, E2 conjugating enzymes, and E3 ligases. Research has linked dysregulation of the Ub/UBLs modification system to numerous diseases including cancer, immunological disorders, and neurodegeneration. Thus, the high substrate specificity provided by combinations of over 30 E2’s and over 600 E3’s makes these enzymes emerging drug targets.

In response to growing market demand, SignalChem has developed an extensive array of products encompassing ubiquitin proteins and active enzymes, Ub/UBL modifiers, and substrates in the ubiquitination, SUMOylation, ISGylation and NEDDylation processes. Using Promega’s AMP-Glo™ technology and an optimized assay protocol, we have identified and validated a variety of functional combinations of the enzyme components. With the established protocol, each enzyme in the catalytic cascade has been assessed for their activity towards the generation of free AMP. In addition, inhibition profiles of the ubiquitinating enzymes have been obtained using the assay system, further demonstrating their potential to be used in high-throughput screening to identify lead compounds for drug discovery and development programs.

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
SAE1/UBA2 Complex, ActiveU208-380GHumanHis/GSTSf9 insect cells using baculovirusFull LengthNM_005500
UBA1 (UBE1), ActiveU201-380GHumanGSTSf9 insect cells using baculovirusFull LengthNM_003334
UBA6, ActiveU206-380GHumanGSTSf9 insect cells using baculovirusFull LengthAL832458
UBA7(UBE1L), ActiveU207-380GHumanGSTSf9 insect cells using baculovirusFull LengthNM_003335
UBA2 (SAE2) ProteinU202-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_005499
UBA3 (UBE1C) ProteinU203-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC022853
UBLE1A (SAE1) ProteinU208-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_005500

Post-translational modification of cellular proteins plays a crucial role in cell survival, cell signaling and overall maintenance of cellular health. Citrullination is one of the many crucial protein modifications catalyzed by a family of enzymes called Protein Arginine Deiminases (PADs). PADs catalyze the hydrolysis of peptidyl-arginine to form peptidyl-citrulline on important cellular proteins such as histones, thereby regulating multiple cell signaling pathways, and biochemical processes.

The PAD family consists of five members of calcium-dependent isozymes PAD1, 2, 3, 4, and 6. Citrullination or hypercitrullination of proteins induces a structural change, modifying their biological function and their interaction mechanisms with other cellular proteins. Because of this property, numerous notable studies have established PADs as an important class of targets for drug discovery projects related to many human diseases such as cancer, autoimmune diseases (rheumatoid arthritis), and neurodegeneration.

SignalChem’s scientists have produced all five high-quality recombinant mammalian PADs and have developed sensitive and reliable PAD assay cocktails to facilitate your drug discovery and development research. These are effective in vitro tools to investigate protein citrullination in various human diseases.

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
PAD Cocktail, ActiveP312-37CGSTSf9 insect cells using baculovirusFull LengthNM_013358 (PAD1)
PAD1, ActiveP312-310GHumanGSTSf9 insect cells using baculovirusFull lengthNM_013358
PAD2, ActiveP312-310BGMouseGSTSf9 insect cells using baculovirusFull lengthBC049947
PAD2, ActiveP312-318BGHumanGSTSf9 insect cells using baculovirusFull lengthNM_007365
PAD3, ActiveP312-310CGHumanGSTSf9 insect cells using baculovirusFull lengthNM_016233
PAD4, ActiveP312-310DGHumanGSTSf9 insect cells using baculovirusFull lengthBC025718
PAD6 ProteinP312-30FGHumanGSTSf9 insect cells using baculovirusFull LengthNM_207421

ATPases and GTPases are two different families of hydrolase enzymes that catalyze the hydrolysis of the third phosphate of ATP and GTP into ADP and GDP respectively. While human ATPases mainly facilitate the transport of cellular metabolites by harnessing the energy released from the ATP hydrolysis, the GTPases conventionally act as “molecular switches” that are essential mediators of signal transduction in the cells. Dephosphorylation of ATP and GTP is an important chemical process in all forms of life, therefore ATPases and GTPases are spread ubiquitously across the plant and the animal kingdom. Mutations in members of these families of enzymes have been observed in many human diseases such as cancer and metabolic disorders. For example, the founding member of the small GTPase Superfamily, Ras, is mutated in about 15% of all human tumors.

SignalChem manufactures high-quality active GTPase and ATPase enzymes such as G protein α subunits, Ras, Rac, and Rho. Our recombinant ATPases/GTPases are perfect candidates to be included in enzyme activity assays and their inhibitor profiling studies. SignalChem’s active GTPases are tested exclusively using Promega’s GTPase-Glo™ Assay.

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
CDC42, ActiveC108-310GHHumanGST/HISE.coliFull LengthNM_001791
GNAI1, ActiveG121-310GHumanGSTE.coli2-endNM_002069
GNAI2, ActiveG122-310GHumanGSTE.coli2-endNM_002070
GNAI3, ActiveG123-310GHumanGSTE.coli2-endNM_006496
GNAS, ActiveG127-310GHumanGSTE.coliFull LengthNM_000516
HRAS1 (Mature form), ActiveR105-310HHumanHISE.coli2-186NM_005343
KRAS (Mature form), ActiveR106-310HHumanHISE.coli2-186NM_033360
NRAS (Mature form), ActiveR107-310HHumanHISE.coli1-186NM_002524
RAC1, ActiveR103-310GHumanGSTE.coliFull LengthNM_006908
RAC2, ActiveR104-310HHumanHISE.coliFull LengthNM_002872
RAC3, ActiveR102-310HHumanHISE.coliFull LengthNM_005052
RhoA (Mature form), ActiveR144-310HHumanHISE.coli1-190NM_001664
RhoC (Mature form), ActiveR144-310CHHumanHISE.coli1-190NM_175744
RhoD (Mature form), ActiveR144-310DHHumanHISE.coli1-207BC001338
VCP, ActiveV116-310GHumanGSTSf9 insect cells using baculovirusFull LengthNM_007126

Phosphodiesterases (PDEs) play a central role in the regulation of various signaling cascades by specifically hydrolyzing the cyclic nucleotides, cAMP, and cGMP into their nucleoside 5’ -– monophosphate form AMP and GMP respectively. Hydrolysis of these nucleotides results in the breakdown of these secondary messengers and the abrogation of downstream signaling. Given the importance of these enzymes in the regulation of cAMP/cGMP signaling, PDEs have been identified as an important class of potential drug targets in diseases such as cancer, neurodegeneration, coronary heart diseases, asthma and more.

Signalchem has successfully manufactured 19 of the 24 phosphodiesterases from the human genome as active enzymes. Our recombinant PDEs are compatible with their substrates cAMP and cGMP and are ready to be included in enzyme activity and inhibitor profiling assays. Our PDEs are tested exclusively using Promega’s PDE-Glo™ Assay technology.

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
PDE10A, ActiveP98-31GHumanGSTSf9 insect cells using baculovirus71-endNM_006661
PDE1A, ActiveP89-30HHumanHISSf9 insect cells using baculovirusFull LengthNM_005019
PDE1B, ActiveP89-30BGHumanGSTSf9 insect cells using baculovirusFull LengthNM_000924
PDE1C, ActiveP89-30CGHumanGSTSf9 insect cells using baculovirusFull LengthNM_005020
PDE2A, ActiveP90-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_002599
PDE3A, ActiveP91-31GHumanGSTSf9 insect cells using baculovirus669-endNM_000921
PDE3B, ActiveP91-31BGHumanGSTSf9 insect cells using baculovirus654-endNM_000922
PDE4A, ActiveP92-31GHumanGSTSf9 insect cells using baculovirus332-endNM_001111307
PDE4B, ActiveP92-31BGHumanGSTSf9 insect cells using baculovirus305-endNM_002600
PDE4C, ActiveP92-31CGHumanGSTSf9 insect cells using baculovirus287-endNM_000923
PDE4D, ActiveP92-31DGHumanGSTSf9 insect cells using baculovirus225-endNM_006203
PDE5A, ActiveP93-31GHumanGSTSf9 insect cells using baculovirus537-endNM_001083
PDE6A, ActiveP94-31GHumanGSTSf9 insect cells using baculovirus31-endNM_000440
PDE6B, ActiveP94-30BGHumanGSTSf9 insect cells using baculovirusFull LengthNM_000283
PDE7A, ActiveP95-31GHumanGSTSf9 insect cells using baculovirus104-endNM_002603
PDE7B, ActiveP95-30BGHumanGSTSf9 insect cells using baculovirusFull LengthNM_018945
PDE8A, ActiveP96-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_002605
PDE8B, ActiveP96-31BGHumanGSTSf9 insect cells using baculovirus113-endNM_003719
PDE9A, ActiveP97-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_001001567

High-quality recombinant proteins are crucial for life science research and drug discovery projects. SignalChem offers a broad range of recombinant proteins including Dihydropyrimidinase, Dioxygenases, lysyl oxidases, superoxide dismutases, and phospholipase C of superior purity. Our in-house team with over 100 years of combined experience in recombinant protein biochemistry stands behind the production and quality of one of the most comprehensive recombinant protein product line in the world.

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
DPYSL2 ProteinD470-30BGHumanGSTSf9 insect cells using baculovirusFull LengthBC056408

SignalChem’s 2019-nCoV (SARS-CoV-2) ELISA kits are important research and detection tools to study the novel SARS-CoV-2 and its molecular interactions with the host cell. Our high-quality ELISA kits can be used for the detection and quantification of SARS-CoV-2 spike protein (RBD) and human anti-SARS-CoV-2 spike protein IgG in biological and recombinant samples.

Catalogue NumberProduct Name
C19SD-8762019-nCoV S1 Protein ELISA Kit
C19S1-8772019-nCoV S1 Human IgG ELISA Kit
C19S1-A8772019-nCoV S1 Human IgA ELISA Kit
C19S1-M8772019-nCoV S1 Human IgM ELISA Kit
C19S1-P8772019-nCoV S1 Human IgG-IgA-IgM ELISA Kit
C19NS1-P8772019-nCoV N-S1 Human IgG-IgA-IgM ELISA Kit
C19NS1-A8772019-nCoV N-S1 Human IgA ELISA Kit
C19NS1-M8772019-nCoV N-S1 Human IgM ELISA Kit
C19NS1-8772019-nCoV N-S1 Human IgG ELISA Kit

Detection Kits

Catalogue NumberProduct Name
P312-863PAD Detection Kit
P312-863-CPAD Detection Kit

Inhibitor Screening Kits

Catalogue NumberProduct Name
P37C-863PAD Cocktail Inhibitor Screening Kit
P318BG-863PAD2 (human) Inhibitor Screening Kit
P310G-863PAD1 Inhibitor Screening Kit
P310DG-863PAD4 Inhibitor Screening Kit
P310CG-863PAD3 Inhibitor Screening Kit
P310BG-863PAD2 (mouse) Inhibitor Screening Kit

SignalChem understands how important it is for the researchers to source high-quality antibodies while working on research projects involving new proteins and other antigens of interest. SignalChem offers a comprehensive range of polyclonal and monoclonal antibodies including primary & secondary antibodies, paralog-specific antibodies, modification antibodies, phospho-specific antibodies, and tag antibodies to support life science research. We also work with scientists to develop custom recombinant antibodies in various cell systems, ready to be used in different immunoassays.

NameCatalog NumberHostCited ApplicationImmunogen
Anti-DYKDDDDKF51-61MMouse, IgG2b, FG4RWB, ELISA, IP, ISDYKDDDDK peptide conjugated to KLH
Anti-DYKDDDDKF51-63RRabbitWBDYKDDDDK peptide conjugated to KLH
Anti-GFPG46-60MMouse, IgG1, GF28RWBGFP N-terminal peptide with KLH conjugate from Aequorea Victoria Jellyfish
Anti-GSTG52-61MMouse, IgG2a, G2RWBPurified GST
Anti-HAH98-61MMouse, IgG3, C10WB, ELISA, IP, IS
Anti-HAH98-63RRabbit PolyclonalWB, ELISA, IP, IS
Anti-HisH99-61MMouse, IgG2b, EH158WB, ELISA, IP, ISHHHHHH peptide conjugated to KLH
Anti-HisH99-63RRabbitWB, ELISA, IP, IS
Anti-MycM86-61MMouse, IgG1, M19WB, ELISA, IP, ISEQKLISEED peptide conjugated to KLH
Anti-RFPR46-61MMouse, IgG1, RF5RWBRFP from the Discosoma sea anemone N-terminal peptide-KLH conjugates
Anti-V5V05-61MMouse, IgG1, V4RRWB, ELISA, IP, ISGKPIPNPLLGLDST peptide conjugated to KLH
NameCatalog NumberHostCited ApplicationImmunogen
Anti-4EBP1E35-563RRabbit, IgGWB, ELISA, ICC4EBP1 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human 4EBP1
Anti-ADD1A38-63RRabbitWBSynthetic peptide corresponding to amino acids 724-728 of human ADD1 (P35611)
Anti-AFXA42-63RRabbitWBSynthetic peptide corresponding to amino acids 195-199 of human AFX
Anti-AKT (pan)A16-63RRabbitWBSynthetic peptide corresponding to amino acids 471-475 of human AKT
Anti-AKT (pan)A16-63BRRabbitWBSynthetic peptide corresponding to amino acids 313-317 of human AKT1 (protein accession number P31749)
Anti-AKT1A16-60MMouse, Monoclonal, 9A4WBRecombinant full length active AKT1 protein
Anti-AKT1A16-63CRRabbit, IgGWB, ELISA, IF, IHCAKT1 antibody was raised against a 16 amino acid synthetic peptide from near the amino-terminus of human AKT1
Anti-AKT2A17-61ARat, IgG2aELISA, IHC, WBThe antibody was produced against synthesized peptide corresponding to internal residues of the human AKT2 protein.
Anti-AKT2/3A17-63BRRabbitWBProtein Code: P31751
Anti-AKT3A18-61MMouse, IgG1ELISA, IHC, WBThe antibody was produced against synthesized peptide corresponding to internal residues of the human AKT3 protein.
Anti-ALK2A06-63RRabbit, IgGWB, ELISAALK2 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of the human ALK2
Anti-ALK4A07-63RRabbit, IgGWB, ELISAALK4 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human ALK4
Anti-ALK7A08-63RRabbit, IgGWB, ELISAALK7 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of the human ALK7
Anti-alpha 1-ActinA03-360MMouse, IgG1, C4WB, IF, IHCChicken gizzard actin
Anti-AMPK alpha 1/2P47-63BRRabbitWBSynthetic peptide corresponding to amino acids 170-174 of human AMPK
Anti-Amyloid betaA06-563RRabbit, IgGWB, ELISA, IF, IHCAmyloid beta antibody was raised against a synthetic peptide corresponding to the amino terminus (aa 1-14) of human beta amyloid conjugated to KLH using maleimide.
Anti-AOS1A80-63RRabbitWBSynthetic peptide of c-terminal amino acid sequence of human AOS1 (Q9UBE0)
Anti-APBA1A86-363RRabbit, IgGWBSynthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH
Anti-APC1A87-363RRabbit, IgGWB, ELISA, IHCAPC1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human APC1
Anti-APC1 (Ser355)A87-363BRRabbit, IgGELISA, IP, WBThe antibody was produced against synthesized peptide corresponding to amino acids 351-359 of Human APC1.
NameCatalog NumberHostCited ApplicationImmunogen
Anti-GOAT, HRP ConjugatedG34-62DCChicken, IgGIdeal working dilutions for each application should be empirically determined by the investigator.The antibody was produced against goat IgG whole molecule
Anti-Mouse HRPG32-62GGoat PolyclonalWB, ELISAAffinity purified mouse immunoglobulins
Anti-MOUSE, AP ConjugatedM32-62ERRabbit, IgGIHC, ELISA, WB (Ideal working dilutions for each application should be empirically determined by the investigator.)The antibody was produced against mouse IgG whole molecule
Anti-MOUSE, Biotin ConjugatedM32-62BGGoat, IgGWB, ELISA, IHC (Ideal working dilutions for each application should be empirically determined by the investigator.)The antibody was produced against mouse IgG whole molecule in goat.
Anti-MOUSE, Fluorescein ConjugatedM32-62CGGoat, IgGELISA, IF Microscopy, Flow Cytometry (Ideal working dilutions for each application should be empirically determined by the investigator.)The antibody was produced against mouse IgG whole molecule.
Anti-MOUSE, Rhodamine ConjugateM32-62FGGoat, IgGELISA, Flow Cytometry, IF Microscopy (Ideal working dilutions for each application should be empirically determined by the investigator.)The antibody was produced against mouse IgG whole molecule.
Anti-Rabbit HRPG33-62GGoat PolyclonalWB, ELISAAffinity purified rabbit immunoglobulins
Anti-RABBIT, AP ConjugatedR33-62EGGoat, IgGELISA, IHC, WB (Ideal working dilutions for each application should be empirically determined by the investigator.)The antibody was produced against Rabbit IgG whole molecule in goat.
Anti-RABBIT, Biotin ConjugatedR33-62BGRabbit, IgGELISA, IHC, WB (Ideal working dilutions for each application should be empirically determined by the investigator.)The antibody was produced against Rabbit IgG whole molecule in goats
Anti-RABBIT, Fluorescein ConjugatedR33-62CGGoat, IgGELISA, Flow Cytometry, IF Microscopy (Ideal working dilutions for each application should be empirically determined by the investigator.)The antibody was produced against Rabbit IgG whole molecule
Anti-RABBIT, Rhodamine ConjugatedR33-62FGGoat, IgGFLISA, FC, IF (Ideal working dilutions for each application should be empirically determined by the investigator.)The antibody was produced against Rabbit IgG whole molecule.
Anti-RAT, HRP ConjugatedA37-62DGGoat, IgGELISA, IHC, WB (Ideal working dilutions for each application should be empirically determined by the investigator.)The antibody was produced against rat IgG whole molecule.
Anti-SHEEP, HRP ConjugatedS36-62DDDonkey, IgGELISA, IHC. WB (Ideal working dilutions for each application should be empirically determined by the investigator.)The antibody was produced against synthesized Sheep IgG whole molecule in donkey.
NameCatalogue NumberHostCited ApplicationImmunogen
Anti-AKT3A18-63RRabbitWBProtein Code: Q9Y243
Anti-AMPK alpha 1P47-63RRabbitWBSynthetic peptide corresponding to amino acids 483-487 of human AMPKα
Anti-CAMK1C07-60MMouse, IgG1, 5H8WBHuman recombinant full length CAMK1 protein
Anti-CHK2C48-60MMouse, IgG1, 7F9WBHuman full length recombinant CHK1
Anti-ERK1M29-60MMouse, IgG1, E32WB, IPRecombinant full length ERK1 protein
Anti-ERK1M29-60BMMouse, IgG1, E19WB, IPRecombinant full length ERK1 protein
Anti-GSK3 alphaG08-63RRabbitWBProtein Code P49840
Anti-GSK3 betaG09-60MMouse, IgG1, 6C2WBRecombinant full length active GSK3β protein
Anti-HSP90 betaH36-63RRabbitWBSynthetic peptide corresponding to amino acids 252-256 of human HSP90β
Anti-JAK2J02-63RRabbitWBSynthetic peptide corresponding to amino acids 1005-1009 of human JAK2
Anti-JNK1M33-63RRabbitWBProtein Code: P45983
Anti-JNK2M34-60MMouse, IgG2, 2G12WB, IPHuman recombinant full length JNK2 protein
Anti-MEK1M02-60MMouse, IgG1, 7F1WB, IPRecombinant full length humanMEK1 protein
Anti-MEK2M03-63RRabbitWBSynthetic peptide corresponding to amino acids 392-396 of human MEK2
Anti-p38 alphaM39-63RRabbitWBC-terminal peptide of p38α conjugated to ovalbumin
Anti-p38 betaM36-63RRabbitWBC-terminal peptide of p38β conjugated to ovalbumin
Anti-p38 gammaM37-63RRabbitWBC-terminal peptide of p38γ conjugated to ovalbumin
Anti-PAK1P02-63RRabbitWBSynthetic peptide corresponding to amino acids 210-214 of human PAK1
Anti-PKC deltaP64-63RRabbitWBSynthetic peptide corresponding to amino acids 643-647 of human PKCδ
Anti-PKC deltaP64-63CRRabbitWBSynthesized peptide derived from C-terminus of human PKCδ protein
Anti-PKC muP72-63RRabbitWBSynthetic peptide corresponding to amino acids 736-740 of human PKCμ
Anti-PKC thetaP74-63RRabbitWBSynthetic peptide corresponding to amino acids 674-678 of human PKCθ
Anti-SMAD2S11-63RRabbitWBSynthetic peptide corresponding to amino acids 218-222 of human SMAD2
Anti-STAT1S52-63RRabbitWBSynthetic peptide corresponding to amino acids 699-703 of human STAT1
Anti-STAT3S54-63BRRabbitWB, IPSynthetic peptide corresponding to amino acids 725-729 of human STAT3
Anti-STAT3S54-63RRabbitWBProtein Code: P40763
Anti-STAT4S55-63RRabbitWBSynthetic peptide corresponding to amino acids 691-695 of human STAT4
Anti-STAT5S56-63RRabbitWBProtein Code: P42229
Anti-STAT5S56-63BRRabbitWBSynthetic peptide corresponding to amino acids 692-696 of human STAT5 (protein accession number P42229)
NameCatalogue NumberHostCited ApplicationImmunogen
Anti-5-Methylated Cytosine (5-methyl cytosine)C92-67SSheep, IgGWB, IP5-Methylated Cytosine (5-methyl cytosine)
Anti-Acetylated LysineL95-66RRabbitWB, ELISA, PI, IHC, IFAcetylated lysine-KLH conjugates
Anti-Acetylated Lysine, Biotin ConjugatedL95-66BRRabbitWB, ELISA, IF, IHC, IPAcetylated lysine-KLH conjugates
Anti-Acetylated Lysine, FITC ConjugatedL95-66CRRabbitFor direct immunofluorescence assayAcetylated lysine-KLH conjugates
Anti-Acetylated Lysine, HRP ConjugatedL95-66DRRabbitWB, ELISA, IF, IHC, IPAcetylated Lysine-KLH conjugates
Anti-Methylated Arginine (NG, NG-Di-methyl)A96-67RRabbitWB, ELISA, IF, IHC, IPNG, NG-di-methylated arginine-KLH conjugates
Anti-Methylated Arginine (NG-Mono-methyl)A95-67RRabbitWB, ELISA, IF, IHC, IPNG-mono-methylated arginine-KLH conjugates
Anti-Methylated Lysine (Tri- epsilon-N-methyl)L95-67RRabbitWB, ELISA, IF, IHC, IPMethylated lysine-KLH conjugates.
Anti-Methylated Lysine (Tri- epsilon-N-methyl), Biotin ConjugatedL95-67BRRabbitWB, ELISA, IF, IHCMethylated lysine-KLH conjugates.
Anti-Methylated Lysine (Tri- epsilon-N-methyl), FITC ConjugatedL95-67CRRabbitFor direct immunofluorescence assayMethylated lysine-KLH conjugates.
Anti-Methylated Lysine (Tri- epsilon-N-methyl), HRP ConjugatedL95-67DRRabbitWB, ELISA, IF, IHC, IPMethylated lysine-KLH conjugates.
Anti-Phosphoserine (Anti-pS)S95-65RRabbitWB, ELISA, IHC, IPPhosphoserine peptide-KLH conjugates
Anti-Phosphoserine (Anti-pS), Biotin ConjugatedS95-65BRRabbitWB, ELISAPhosphoserine peptide-KLH conjugates
Anti-Phosphothreonine (Anti-pT)T95-65RRabbitWB, ELISA, IHC, IPPhosphothreonine peptide-KLH conjugates
Anti-Phosphothreonine (Anti-pT), Biotin ConjugatedT95-65BRRabbitWB, ELISAPhosphothreonine peptide-KLH conjugates
Anti-Phosphotyrosine (Anti-pY)T96-65RRabbitWB, ELISA, IHC, IPPhosphotyrosine peptide-KLH conjugates
Anti-Phosphotyrosine (Anti-pY), Biotin ConjugatedT96-65BRRabbitWB, ELISA, IHC, IPPhosphotyrosine peptide-KLH conjugates
NameCatalog NumberHostCited ApplicationImmunogen
Anti-phospho-14-3-3 beta (Ser58)Y71-365RRabbit, IgGWB, IHCSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser58 conjugated to KLH
Anti-phospho-4EBP1 (Thr45)E35-365RRabbit, IgGWB, IHCSynthetic phospho-peptide corresponding to amino acid residues surrounding Thr45
Anti-phospho-AKT1/2/3 (Ser473)A16-65BRRabbit, IgGWB, IHCSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser473
Anti-phospho-AKT1/2/3 (Ser473)A16-65BMMouse, IgG1ELISA, IHC, IF, WBThe antibody was produced against synthesized peptide corresponding to residues surrounding Ser 473 of human AKT1 protein.
Anti-phospho-AKT1/2/3 (Thr308)A16-65RRabbit, IgGWB, IHCSynthetic phospho-peptide corresponding to amino acid residues surrounding Thr308
Anti-phospho-AKT1/2/3 (Thr308)A16-65MMouse, IgGELISA, IHC, WBThe antibody was produced against synthesized peptide corresponding to residues surrounding Thr 308 of Human AKT1 protein.
Anti-Phospho-APC1 (Ser377)A87-365RRabbit, IgGELISA, IHC, WBThe antibody was produced against synthesized peptide corresponding to amino acids 373-382 of human APC1 protein.
Anti-Phospho-APC3 (Ser427)A89-365BRRabbit, IgGELISA, WBThe antibody was produced against synthesized peptide corresponding to amino acids 422-430 of human Cdc27 protein.
Anti-Phospho-APC3 (Thr 244)A89-365RRabbit, IgGELISA, IP, WBThe antibody was produced against synthesized peptide corresponding to amino acids 239-240 of Human Cdc27 protein.
Anti-Phospho-ASK1 (Ser83)M13-65BRRabbit, IgGELISA, WBThe antibody was produced against synthesized peptide corresponding to amino acids 76-87 on human ASK1 protein.
Anti-phospho-ASK1 (Ser966)M13-65RRabbit, IgGIHCSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser966
Anti-phospho-ATF2 (Ser112)A10-565RRabbit, IgGIHCSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser112
Anti-phospho-ATF2 (Ser490 Ser498)A10-565BRRabbit, IgGWB, IHCSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser490/498 conjugated to KLH
Anti-Phospho-ATM (Ser1981)A26-65SSheep, IgGELISA, WBThe antibody was produced against synthesized peptide corresponding to a region near serine 1981 of human ATM conjugated to KLH.
Anti-Phospho-AURORA B (Thr 232)A31-65RRabbit, IgGELISA, IF, WBThe antibody was produced against synthesized peptide corresponding to amino acids 223-234 of Human Aurora Kinase B protein.
Anti-phospho-BRCA1 (Ser1423)B87-365RRabbit, IgGIHCSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser1423
Anti-phospho-c-KIT (Tyr721)K06-65RRabbit, IgGWBThe antiserum was produced against synthesized phosphopeptide derived from human c-KIT around the phosphorylation site of tyrosine 721 (N-E-YP-M-D).
Anti-phospho-c-KIT (Tyr936)K06-65BRRabbit, IgGIHCThe antibody was produced against synthesized phosphopeptide derived from human c-KIT around the phosphorylation site of tyrosine 936 (H-I-Y-P-S-N).
Anti-phospho-CAMK2A/2B (Thr286)C11-65RRabbit, IgGWBSynthetic phospho-peptide corresponding to amino acid residues surrounding Thr286 conjugated to KLH
Anti-phospho-Catenin beta (Ser33 Ser37)C06-365RRabbit, IgGWBSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser33/37 conjugated to KLH

SignalChem manufactures a broad range of recombinant cell signaling proteins paying thorough attention to quality to assist in global academic research and drug discovery efforts. Our comprehensive family offering of signaling protein products have been utilized by many pharmaceutical companies in their research and drug discovery programs. Explore Signalchem’s cell signaling protein product range to study molecular and cell signaling pathways.

Adaptor Proteins

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
FADD ProteinF02-30HHumanHISE.coliFull LengthNM_003824
GAB1 ProteinG03-30HHumanHISSf9 insect cells using baculovirusFull LengthNM_207123
GRB2 ProteinG45-30GHumanGSTE.coliFull LengthNM_002086
GRB7 ProteinG45-30GGHumanGSTE.coliFull LengthNM_001030002
NCK ProteinN06-30HHumanHISSf9 insect cells using baculovirusFull LengthNM_006153
TRAF1 ProteinT56-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_005658
TRAF2 ProteinT57-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_021138

Apoptosis Proteins

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
ATG13 ProteinA113-30GHumanGSTE.coliFull LengthNM_001142673
BAD ProteinB03-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_032989
BAG1 ProteinB05-31GHumanGSTE.coli72-endNM_004323
BAX ProteinB14-30GHumanGSTE.coliFull LengthNM_004324
BCL2 ProteinB25-30GHumanGSTE.coliFull LengthNM_000633
BID ProteinB59-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC036364
XIAP ProteinX08-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_001167

Cell Cycle Proteins

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
CDC7 ProteinC26-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_003503
CDK2 ProteinC29-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_001798
CDK5P25 ProteinC34-31GHumanGSTSf9 insect cells using baculovirus98-endNM_003885
CDK5P35 ProteinC34-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_003885
CDKN3 ProteinC01-34GHumanGSTSf9 insect cells using baculovirusFull LengthNM_005192
Cyclin E2 ProteinC82-30BGHumanGSTSf9 insect cells using baculovirusFull LengthNM_057749
Cyclin T2 ProteinC86-30BGHumanGSTSf9 insect cells using baculovirusFull-LengthNM_001241
Cyclin Y ProteinC87-30GHumanGSTSf9 insect cells using baculovirus2-endNM_145012
CyclinA2 ProteinC78-30BGHumanGSTSf9 insect cells using baculovirusFull LengthNM_001237
CyclinC ProteinC80-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_005190
CyclinD1 ProteinC81-30GHumanGSTE.coliFull LengthNM_053056
CyclinD1 ProteinC81-30BGHumanGSTSf9 insect cells using baculovirusFull LengthNM_053056
CyclinD3 ProteinC81-30B3GHumanGSTSf9 insect cells using baculovirusFull lengthNM_001760
CyclinE1 ProteinC82-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_001238
CyclinH ProteinC83-30HHumanHISSf9 insect cells using baculovirusFull LengthNM_001239
CyclinK ProteinC84-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC015935
CyclinO ProteinC85-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_021147
MDM2 (1-118) ProteinM45-31BHHumanHISE.coli1-118NM_002392
MDM2 ProteinM45-31GHumanGSTE.coli202-endNM_002392
MDM4 (1-137) ProteinM47-31BHHumanHISE.coli1-137NM_002393
p15INK4B ProteinC31-30GHumanGSTE.coliFull LengthNM_004936
p16INK4A ProteinC30-30GHumanGSTE.coliFull LengthNM_000077
p18INK4C ProteinC32-30GHumanGSTE.coliFull LengthNM_001262
p19INK4D ProteinC33-30GHumanGSTE.coliFull LengthNM_001800
p21CIP1 ProteinC27-30GHumanGSTE.coliFull LengthNM_000389
p27KIP1 ProteinC28-30GHumanGSTE.coliFull LengthNM_004064
p33ING1 ProteinI32-30HHumanHISSf9 insect cells using baculovirusFull LengthNM_198219
p33ING2 ProteinI32-30BGHumanGSTSf9 insect cells using baculovirusFull LengthNM_001564
p53 ProteinP05-30GHumanGSTE.coliFull LengthNM_000546
p53 ProteinP05-30BGHumanGSTHi5 insect cells using baculovirusFull LengthNM_000546
p63 ProteinP06-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_001114980
p73 alpha ProteinP08-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_005427
p73 beta ProteinP08-30BGHumanGSTSf9 insect cells using baculovirusFull LengthO15350-2
p73 gamma ProteinP08-30CGHumanGSTSf9 insect cells using baculovirusFull LengthO15350-3

Cell Stress & Chaperone Proteins

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
14-3-3 alpha/beta ProteinY71-30GHumanGSTE.coliFull LengthNM_003404
14-3-3 alpha/beta ProteinY71-30NHumanTAG-FreeE.coliFull LengthNM_003404
14-3-3 alpha/beta ProteinY71-30HHumanHISSf9 insect cells using baculovirusFull LengthNM_003404
14-3-3 alpha/beta ProteinY71-30BHMouseHISSf9 insect cells using baculovirusFull LengthNM_018753
14-3-3 epsilon ProteinY75-30GHumanGSTE.coliFull LengthNM_006761
14-3-3 epsilon ProteinY75-30NHumanTAG-FreeE.coliFull LengthNM_006761
14-3-3 epsilon ProteinY75-30HHumanHISSf9 insect cells using baculovirusYWHAE, MDS, MDCR, KCIP-1, 14-3-3E, FLJ45465NM_006761
14-3-3 epsilon ProteinY75-30BHMouseHISSf9 insect cells using baculovirusNM_009536
14-3-3 sigma ProteinY86-30GHumanGSTE.coliFull LengthNM_006142
14-3-3 sigma ProteinY86-30NHumanTAG-FreeE.coliFull LengthNM_006142
14-3-3 sigma ProteinY86-30HHumanHISSf9 insect cells using baculovirusFull LengthNM_006142
14-3-3 theta ProteinY84-30GHumanGSTE.coliFull LengthNM_006826
14-3-3 theta ProteinY84-30NHumanTAG-FreeE.coliFull LengthNM_006826
14-3-3 theta ProteinY84-30HHumanHISSf9 insect cells using baculovirusFull LengthNM_006826
14-3-3 theta ProteinY84-30BHMouseHISSf9 insect cells using baculovirusFull LengthNM_011739
14-3-3 zeta ProteinY92-30GHumanGSTE.coliFull LengthNM_003406
14-3-3 zeta ProteinY92-30NHumanTAG-FreeE.coliFull LengthNM_003406
14-3-3 zeta ProteinY92-30HHumanHISSf9 insect cells using baculovirusFull LengthNM_003406
14-3-3 zeta ProteinY92-30BHMouseHISSf9 insect cells using baculovirusFull LengthNM_011740
CRYAA ProteinC256-30HHumanHISE.coliFull LengthNM_000394
GST ProteinG52-30UArtificialTAG-FreeE.coli1-226U13850
HO1 ProteinH20-30GHumanGSTE.coliFull LengthNM_002133
HO2 ProteinH21-30GHumanGSTE.coliFull LengthNM_002134
HSP10 ProteinH29-54GHumanGSTE.coliFull LengthNM_002157
HSP27 ProteinH30-54GHumanGSTE.coliFull LengthNM_001540
HSP40 ProteinH32-54GHumanGSTE.coliFull LengthNM_006145
HSP60 ProteinH33-54GHumanGSTE.coliFull LengthNM_002156
HSP70 ProteinH34-54GHumanGSTE.coliFull LengthNM_005345
HSP70 ProteinH34-54HHumanHISSf9 insect cells using baculovirusFull LengthNM_005345
HSP90 alpha ProteinH36-50HHumanHISSf9 insect cells using baculovirusFull LengthNM_005348
HSP90 beta ProteinH36-54HHumanHISSf9 insect cells using baculovirusFull LengthNM_ 007355
Mortalin ProteinM54-31GHumanGSTSf9 insect cells using baculovirus47-endNM_004134
PARK7 (DJ-1) ProteinP219-31HHumanHISE.coli19-endNM_007262

Color Proteins

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
BFP ProteinB620-30HHISE.coli228-endDQ399412
eRFP ProteinR620-30BHHISE.coliFull LengthAY130757
Red ProteinR620-30CHHISE.coliFull LengthEU498726
RFP ProteinR620-30HHISE.coliFull LengthAAF03369
Y1BFP ProteinB620-30BHHISE.coliFull LengthBAG71497

Microtubule & Actin Associated Proteins

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
Alpha-synuclein ProteinS22-30HHumanHISE.coliFull LengthNM_000345
Beta-synuclein ProteinS22-30BHHumanE.coliFull LengthNM_003085
Cofilin 1 ProteinC37-54HHumanHISE.coliFull LengthNM_005507
Gamma-synuclein ProteinS22-30CHHumanHISE.coliFull LengthNM_003087
INCENP ProteinI30-31HHumanHISSf9 insect cells using baculovirus783-endNM_001040694
Stathmin ProteinS71-30HHumanHISE.coliFull LengthBC014353
TPM3 ProteinT36-30HHumanHISE.coliFull LengthNM_152263
TPX2 ProteinT40-30HHumanHISSf9 insect cells using baculovirusFull LengthNM_012112
Troponin1 ProteinT68-30HHumanHISE.coliFull LengthNM_003281
Tubulin Beta (TUBB1) ProteinT92-50GHumanGSTE.coliFull LengthNM_178014
Vimentin ProteinV49-30HHumanHISE.coliFull LengthNM_003380

Regulatory Proteins

Transcription Proteins

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
ATF1 ProteinA09-54GHumanGSTSf9 insect cells using baculovirusFull LengthNM_005171
c-JUN ProteinJ05-55GHumanGSTE.coliJan-79NM_002228
Catenin alpha ProteinC05-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_001903
Catenin beta ProteinC06-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_001904
CBP ProteinC07-31GHumanGSTE.coli1319-1710NM_004380
CREB1 ProteinC49-55GRatGSTE.coli1-280NM_031017
ELK1 ProteinE64-30GHumanGSTE.coliFull LengthNM_005229
FOS ProteinF66-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_005252
FOXL2 ProteinF71-30BGHumanGSTSf9 insect cells using baculovirusFull LengthNM_023067
HIF1B ProteinH07-30BGHumanGSTSf9 insect cells using baculovirusFull LengthNM_001668
HSF1 ProteinH25-30GHumanGSTE.coliFull LengthNM_005526
IkBA ProteinI20-30GHumanGSTE.coliFull LengthNM_020529
IkBA ProteinI20-31GHumanGSTE.coli1-175NM_020529
IkBB ProteinI21-30GHumanGSTE.coliFull LengthNM_002503
NFATC1 ProteinN12-30GHumanGSTSf9 insect cells using baculovirusFull LengthNM_172390
NFKB2 ProteinN13-31GHumanGSTSf9 insect cells using baculovirus1-454NM_002502
Rel B ProteinR30-30HHumanHISSf9 insect cells using baculovirusFull LengthNM_006509
SMAD1 ProteinS10-30GHumanGSTE.coliFull LengthNM_005900
SMAD2 (del SXS) ProteinS11-31GHumanGSTE.coliC-terminal SXS deletionNM_001003652
SMAD2 ProteinS11-30GHumanGSTE.coliFull LengthNM_001003652
SMAD3 (del SXS) ProteinS12-31GHumanGSTE.coliC-terminal SXS deletionNM_005902
SMAD3 ProteinS12-30GHumanGSTE.coliFull LengthNM_005902
SMAD4 ProteinS13-30GHumanGSTE.coliFull LengthNM_005359
SMAD5 ProteinS14-30GHumanGSTE.coliFull LengthNM_005903
SMAD9 ProteinS17-30GHumanGSTE.coliFull LengthNM_001127217
STAT1 alpha ProteinS52-50GHumanGSTSf9 insect cells using baculovirusFull LengthNM_139266
STAT1 beta ProteinS52-54GHumanGSTSf9 insect cells using baculovirusFull LengthNM_139266
STAT2 ProteinS53-54GHumanGSTSf9 insect cells using baculovirusFull LengthNM_005419
STAT3 ProteinS54-54GHumanGSTSf9 insect cells using baculovirusFull LengthNM_139276
STAT3 ProteinS54-54BHHumanHISSf9 insect cells using baculovirusFull LengthNM_139276
STAT4 ProteinS55-54HHumanHISSf9 insect cells using baculovirusFull LengthNM_003151
STAT5 ProteinS56-54HHumanHISSf9 insect cells using baculovirusFull LengthNM_003152
STAT5B ProteinS56-54BGHumanGSTSf9 insect cells using baculovirusFull LengthBC065227
STAT5B ProteinS56-54BHHumanHISSf9 insect cells using baculovirusFull LengthBC065227
STAT6 ProteinS57-30GHumanGSTSf9 insect cells using baculovirusFull LengthBC075852
TDP43 ProteinT74-30GHumanGSTE.coliFull LengthNM_007375

SignalChem offers a wide range of recombinant cytokines, chemokines and growth factors manufactured under strict quality controls. With high purity and endotoxin levels of ≤ 0.1 ng/ug (IEU/ug), our ligands are perfect candidates to be included in your research and drug discovery projects.

Growth Factors

Chemokines

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
IP-10I838-40NHumanHISE.coli22-98NP_001556.2
RANTES (CCL5)R801-40NHumanE.coliAAH08600
SDF-1S821-40NE.coliMKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALN

Cytokines

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
IFN-gammaI837-40NHumanE.coliNP_000610.2
TNF-alphaT860-40NHumanE.coliP01375
TNF-betaT861-40BGMouseGSTSf9 insect cells using baculovirus34-endP09225
TNFBT861-40NHumanE.coli35-205AAH34729.1
TRAILT880-40NHumanE.coli114-281NP_003801.1
VEGF-CV812-40NHumanE.coliNP_005420.1

Tau proteins constitute a family of very important neuronal proteins that bind to the neuronal microtubules. As one of the first discovered and characterized microtubule-associated proteins, the role of Tau proteins has ever since been associated with an array of neuro-biochemical processes including formation and maintenance of neuronal transport system. Researchers have been constantly monitoring the role of myriad Tau proteins in neuronal pathways and their mutagenesis in neurodegenerative disorders such as Alzheimer’s disease.

Abnormal phosphorylation of Tau can lead to deposits of Tau filaments leading to severe pathogenesis in multiple neurodegenerative disorders such as Alzheimer’s disease. Over the years there has been an exponential boost in Tau research after multiple neurodegenerative diseases displayed tangled forms of Tau proteins in the brain. These observations have established Tau proteins as key potential therapeutic targets for neurodegenerative diseases and motivated scientists globally to invest their drug discovery efforts in understanding the Tau proteins and in developing novel therapeutics to modulate their functions.

Signalchem manufactures one of the most comprehensive selections of recombinant Tau proteins in the world. These include various protein isoforms, phospho-Taus, and mutant variants. Our selection of a wide range of Tau proteins demonstrates SignalChem’s drive to provide quality reagents to facilitate research in neurobiology and these proteins have so far been utilized in a variety of fields including neurodegeneration, oncology, epigenetics, cell stress, and more.

NameCatalog NumberSpeciesTagExpression SystemSequenceGenbank Number
Tau Protein MarkerT08-07N
Tau-316 ProteinT02-54NHumanTAG-FreeE.coliFull LengthP10636-3
Tau-352 ProteinT03-54NHumanTAG-FreeE.coliFull LengthP10636-2
Tau-381 ProteinT04-54NHumanTAG-FreeE.coliFull LengthP10636-4
Tau-383 (N352H) ProteinT05-56NHumanTAG-FreeE.coliFull Length (N352H)P10636-6
Tau-383 ProteinT05-54NHumanTAG-FreeE.coliFull LengthP10636-6
Tau-410 ProteinT06-54NHumanTAG-FreeE.coliFull LengthP10636-5
Tau-412 ProteinT07-54NHumanTAG-FreeE.coliFull LengthP10636-7
Tau-412, GSK3beta-phosphorylatedT07-50CNHumanE.coliFull lengthP10636-7
Tau-441 (1-391) ProteinT08-55CNHumanTAG-FreeE.coli1-391P10636-8
Tau-441 (1-421) ProteinT08-55BNHumanTAG-FreeE.coli1-421P10636-8
Tau-441 (127-421) ProteinT08-55KNHumanE.coli127-421P10636-8
Tau-441 (151-391) ProteinT08-55FNHumanTAG-FreeE.coli151-391P10636-8
Tau-441 (151-421) ProteinT08-55ENHumanTAG-FreeE.coli151-421P10636-8
Tau-441 (151-441) ProteinT08-55DNHumanTAG-FreeE.coli151-441P10636-8
Tau-441 (216-391) ProteinT08-55LNHumanTAG-FreeE.coli216-391P10636-8
Tau-441 (231-391) ProteinT08-55INHumanTAG-FreeE.coli231-391P10636-8
Tau-441 (231-421) ProteinT08-55HNHumanTAG-FreeE.coli231-421P10636-8
Tau-441 (231-441) ProteinT08-55GNHumanTAG-FreeE.coli231-441P10636-8
Tau-441 (244-372) ProteinT08-55NHumanTAG-FreeE.coli244-372P10636-8

Compounds such as enzyme activity modulators (activators and inhibitors) are important tools to study an enzyme’s role in key cell signaling pathways and enzymatic reactions. SignalChem offers one of the most comprehensive ranges of biologically active recombinant enzymes as well as a broad range of high- quality/low-cost enzyme activators and inhibitors of different classes of enzymes including protein kinases, phosphatases, and epigenetic enzymes. These compounds would enable scientists to study cell signaling pathways and facilitate enzyme research and drug discovery projects.

NameCatalog NumberCAS Registration NumberMolecular FormulaPurityChemical Name
6BIOG08-900667463-62-9C16H10BrN3O298% (TLC: 5% CH3OH3 in CH2Cl2, Rf=0.43); NMR (Conforms)(2’Z,3’E)-6-Bromoindirubin -3′-oxime
7-CL-O-Nec-1R07-901B852391-15-2C13H12ClN3O>98% (TLC); NMR (Conforms)Nec-1s; 5-((7-Chloro-1H-indol -3-yl)methyl)-3-methylimidazolidine-2,4-dione
A83-01A09-900909910-43-6C25H19N5S>98% (TLC); NMR (Conforms)3-(6-Methyl-2-pyridinyl)-N-phenyl -4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
AAL-993F11-900C269390-77-4C20H16F3N3O>98% (TLC); NMR (Conforms)2-((4-Pyridyl)methyl)amino-N-(3 (trifluoromethyl)phenyl)benzamide
AG-1296P12-900146535-11-7C16H14N2O2>98% (TLC); NMR (Conforms)6,7-Dimethoxy-3-phenyl quinoxaline
AG-1478E10-900B175178-82-2C16H14ClN3O2>98% (TLC); NMR (Conforms)1. N-(3-Chlorophenyl)-6,7- dimethoxy-4-quinazolinanine
AG-1517K11-900B153436-54-5C16H14BrN3O2 ∙ HCl>98% (TLC); NMR (Conforms)1. 4-(3-Bromoanilino)-6,7- dimethoxyquinazoline hydrochloride
AG-490J02-901133550-30-8C17H14N2O3>98% (TLC); NMR (Conforms)(E)-2-Cyano-3-(3,4-dihydrophenyl) -N-(phenylmethyl)-2-propenamide
AG-879N28-909B148741-30-4C18H24N2OS>99% (TLC); NMR (Conforms)alpha-Cyano-(3,5-di-t-butyl-4-hydroxy) thiocinnamide
AlsterpaulloneG09-901C237430-03-4C16H11N3O3>96% (TLC); NMR (Conforms)9-Nitro-7,12-dihydroindolo-[3,2-d] [1] benzazepin-6(5)-one
AmlexanoxT02-90168302-57-8C16H14N2O4>98% (TLC); NMR (Conforms)2-Amino-7-(1-methylethyl)-5-oxo-5H- [1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
ApigeninK10-900C520-36-5C15H10O5>98% (TLC); NMR (Conforms)4’,5,7-Trihydroxyflavone
AR-A014418G09-901487021-52-3C12H12N4O4S>98% (TLC); NMR (Conforms)N-[(4-Methoxyphenyl) methyl]-N’-(5-nitro-2-thiazolyl) urea
AS-041164P29-9016318-41-8C11H7NO4S>98% (TLC); NMR (Conforms)1. 5-Benzo[1,3]dioxol-5- ylmethylene-thiazolidine-2,4-dione
BAY 11-7082C51-90019542-67-7C10H9NO2S>98% (TLC); NMR (Conforms)(E)-3-[(4-methylphenylsulfonyl] -2-propenenitrile
BML-259C33-901267654-00-2C14H16N2OS>98% (TLC: 5% CH3OH/CH2Cl2; Rf=0.46); NMR (Conforms)N-(5-Isopropylthiazol-2-yl) phenylacetamide
BML-277C48-901516480-79-8C20H14ClN3O2≥98% (TLC; 1:1 ethylacetate: hexane; Rf=0.17); NMR (Conforms)1. 2-(4-(4-chlorophenoxy)phenyl)- 1H-benzimidazole-5-carboxamide
BRD-7389R15-901376382-11-5C24H18N2O2>98% (TLC); NMR (Conforms)1-[(2-Phenylethyl)amino]-3H-naphtho [1,2,3-de]quinoline-2,7-dione
CHIR-99021G09-901B252917-06-9C22H18Cl2N8>98% (TLC); NMR (Conforms)6-[[2-[[4-(2,4-Dichlorophenyl)-5- (5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl] amino] ethyl] amino]-3-pyridinecarbonitrile
CID-2011756P72-901638156-11-3C22H21ClN2O3≥98% (TLC); NMR (Conforms)5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl) phenyl]-2-furancarboxamide
NameCatalog NumberCAS Registration NumberMolecular FormulaPurityChemical Name
CantharidinP16-902C56-25-7C10H12O4>98% (HPLC)3α,7α-Dimethylhexahydro-4,7- epoxyisobenzofuran-1,3-dione
NSC-663284C04-902383907-43-5C15H16ClN3O3>98%6-Chloro-7-[[2-(4-morpholinyl) ethyl]amino]-5,8-quinolinedione
Okadaic acid, free acidP16-90278111-17-8C44H68O13>98% (TLC)None
NameCatalog NumberCAS Registration NumberMolecular FormulaPurityChemical Name
2’-Deoxy-5-fluorocytidineD353-904D10356-76-0C9H12FN3O4>98%5-Fluoro-2’-deoxycytidine; FCDR; FdCyd; NSC-48006
5-AzacytidineD353-904320-67-2C8H12N4O5>98% (TLC)4-Amino-1-(beta-D-ribofuranosyl)- 1,3,5-triazin-2(1H)-one, Ladakamycin
AK-7S36-904420831-40-9C19H21BrN2O3S98% (TLC)N-(3-Bromophenyl)-3-[(hexahydro-1H -azepin-1-yl)sulfonyl]benzamide
APICIDINH83-904B183506-66-3C34H49N5O6≥98%Cyclo[(2S)-2-Amino-8-oxodecanoyl-1- methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
BIX-01294 3HClS344-903935693-62-2C28H38N6O2.3HCl>98%2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl) -6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl] -4-quinazolinamine trihydrochloride
BML-210H83-904C537034-17-6C20H25N3O298%N1-(2-aminophenyl)-N8-phenyloctanediamide
C-646K311-903328968-36-1C24H19N3O6>98%4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl] methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
ChaetocinK421-904C28097-03-2C30H28N6O6S4>99%Lys methyltransferase inhibitor
CPTH2K311-903B357649-93-5C14H14ClN3S>98% (TLC)Cyclopentylidene-[4-(4’-chlorophenyl)thiazol-2-yl]hydrazone
CUDC-101H83-9041012054-59-9C24H26N4O4>99% (HPLC)7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin -6-yl)oxy)-N-hydroxyheptanamide
DaminozideK421-904B1596-84-5C6H12N2O398%1-(2,2-Dimethylhydrazide)butanedioic acid
DecitabineD353-904B2353-33-5C8H12N4O4>98%5-Aza-2’-deoxycytidine; NSC-127716
DMOGJ48-90489464-63-1C6H9NO5>98%N-(2-Methoxy-2-oxoacetyl)glycine methyl ester; Dimethyloxalylglycine
EX-527S35-904F49843-98-3C13H13ClN2O98% (TLC)6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (racemic)
GarcinolK311-903C78824-30-3C38H50O6>97% (TLC)Camboginol, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl- 1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2- (1-methylethenyl)-4-hexen-1-yl]- bicyclo[3.3.1]non-3-ene-2,9-dione
GSK-J1 (Free acid)J48-904B1373422-53-7C22H23N5O299%N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3- benzazepin-3-yl)-4-pyrimidinyl]-β-alanine
GSK-J4 (ethylester)J48-904C1373423-53-0C24H27N5O2>99%N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3- benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
HPA (HEXYL-4-PENTYNOIC ACID)H83-904D96017-59-3C11H18O2>97% (TLC)2-(2-propynyl)octanoic acid (racemic); HPA
IOX1 (8H5QCA)J48-904D5852-78-8C10H7NO3>98% (HPLC)5-Carboxy-8-hydroxyquinoline, 8-Hydroxy-5-quinolinecarboxylic acid
ML-324J48-904E1222800-79-4C21H23N3O2>98% (TLC)N-(3-(dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide
NameCatalog NumberCAS Registration NumberMolecular FormulaPurityChemical Name
BML-278S35-904CN/FC24H25NO4>98% (TLC)N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
CTPBP07-903586976-24-1C31H43ClF3NO298%N-(4-chloro-3-trifluoromethyl-phenyl) -2-ethoxy-6-pentadecyl-benzamide
ResveratrolS35-904501-36-0C14H12O3>98%3,4’,5-Trihydroxy-trans-stilbene; 5-[(1E)-2- (4-Hydroxyphenyl)ethenyl]-1,3,benzenediol
SirtActS35-904E839699-72-8C20H25N5O298% (TLC)2-Amino-N-cyclopentyl-1-(3-methoxypropyl) -1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide; CAY10591
NameCatalog NumberCAS Registration NumberMolecular FormulaPurityChemical Name
8-pCPT-2-O-Me-cAMP-AMR46-9051152197-23-3C20H21ClN5O8PS>97% (HPLC)8-(4-Chlorophenylthio)-2′-O-methyladenosine-3’, 5′-cyclic monophosphate acetoxymethyl ester
AICARP47-900B2627-69-2C9H14N4O5>99% (TLC); NMR (Conforms)1. 5-Aminoimidazole-4-carboxamide 1-B-D-ribofuranoside 2. Acadesine
MHY-1485F17-901B326914-06-1C17H21N7O4>98% (TLC); NMR (conforms)4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
SC-79A16-901305834-79-1C17H17ClN2O598% (TLC); NMR (Conforms)2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl) -4H-1-benzopyran-4-acetic acid, ethyl ester

Bioreagents are crucial components in regular laboratory applications like enzyme assays. Without high-quality reagents, it is impossible to generate desired assay results, hampering important disease research and drug discovery projects. Our scientific team has over 100 years of combined research and industrial experience in the recombinant proteins and bioreagent production.

SignalChem’s expertise allows us to understand the importance of the quality of assay reagents and substrates in research and our goal is to provide highest-quality bioreagents to the global scientific community. We offer high quality and cost-effective bioreagents such as assay reagents, peptide substrates, oligo substrates, lipid substrates, and more.

NameCatalog NumberApplication
Acetyltransferase Assay BufferA01-09Acetyltransferase Assay
Acetyltransferase Dilution BufferA21-09Acetyltransferase Assay
AMP SolutionA46-09Kinase Assay
ATP Stock SolutionA50-09Kinase Assay
Ca2+/Calmodulin Solution II, 10xC02-39BKinase Assay
CaCl2 SolutionC02-09Enzyme Assay
cAMP SolutionA47-09Enzyme Assay
cGMP SolutionG47-09Enzyme Assay
DTT SolutionD86-09B
DTT SolutionD86-09
DUB Reaction Buffer (4X)D01-09
Fructose Kinase Assay Buffer IF01-09Enzyme Assay
Fructose Kinase Dilution Buffer IF21-09Enzyme Assay
GTP SolutionG50-09Enzyme Assay
GTP Solution IIG50-09BEnzyme Assay
Kinase Assay Buffer IK01-09Kinase Assay
Kinase Assay Buffer IIK02-09Kinase Assay
Kinase Assay Buffer IIIK03-09
Kinase Dilution Buffer IK21-09Kinase Assay
Kinase Dilution Buffer IIK22-09Kinase Assay

Bioreagents are crucial components in regular laboratory applications like enzyme assays. It is essential to use high-quality bioreagents to develop reliable assay methods and to generate reproducible and good-quality assay results. Our scientific team has over 100 years of combined research and industrial experience in the production of recombinant proteins and bioreagents. We leverage our expertise and experience to provide the global scientific community with the high quality and cost-effective bioreagents such as assay reagents, peptide substrates, oligo substrates, lipid substrates, siRNA reagents and more.

NameCatalog Number
DLG (Dilauroyl-sn-glycerol)D430-59
PI (Phosphatidylinositol)P420-59
PI(3)PP421-59
PI(3)P:PSP426-59
PI(4)PP422-59
PI(4)P:PSP427-59
PI(4,5)P2P424-59
PI(4,5)P2:PSP429-59
PI(5)PP423-59
PI(5)P:PSP428-59
PI:PSP425-59B
NameCatalog NumberApplication
DNMT Substrate-1D53-58DNA methyltransferase assay (50pmole per reaction).
METTL3/METTL14 SubstrateM323-58A methyltransferase METTL3/METTL14 complex assay.
Poly (1:1 dI, dC) AcidP62-58DNA methyltransferase assay (0.25ug per reaction).
NameCatalog NumberApplication
AbltideA02-58Kinase Assay
Acetylated Histone H3 Peptide IH12-358Acetylation/Methylation Assays
Acetylated Histone H4 Peptide IH13-358Acetylation/Methylation Assays
AKT (PKB) SubstrateA05-58Kinase Assay
AKT (SGK) SubstrateA08-58Kinase Assay
AMARA PeptideA11-58Kinase Assay
Amyloid beta (1-11) PeptideA06-558B
Amyloid beta (1-15) PeptideA06-558I
Amyloid beta (11-20) PeptideA06-558K
Amyloid beta (11-40) PeptideA06-558G
Amyloid beta (11-40), pyrEA06-558H
Amyloid beta (11-42) PeptideA06-558W
Amyloid beta (11-42), pyrEA06-558X
Amyloid beta (12-28) PeptideA06-558L
Amyloid beta (17-28) PeptideA06-558M
Amyloid beta (25-35), C-terminal-amideA06-558O
Amyloid beta (25-35), C-terminal-OHA06-558N
Amyloid beta (25-35), N-Alpha-Biot-LC LabeledA06-558Q
Amyloid beta (25-35), ScrambledA06-558P
Amyloid beta (29-40) PeptideA06-558R
NameCatalog NumberApplication
ARPP19 ProteinA76-54GWestern Blot
Casein ProteinC03-54NKinase Assay, Western Blot
Casein, DephosphorylatedC03-54BNKinase Assay, Western Blot
DUB Substrate IU06-57
DUB Substrate IIS293-57
DUB Substrate IIIN263-57
Histone H1 ProteinH10-54NKinase Assay, Western Blot
Histone H3 ProteinH12-54NKinase Assay, Western Blot
LC20 ProteinM89-54GKinase Assay, Western Blot
MBP ProteinM42-51NKinase Assay, Western Blot
Moesin ProteinM52-55GKinase Assay, Western Blot
PDHA1 ProteinP57-55HKinase Assay, Western Blot
RanGAP1 ProteinR298-31HWestern Blot
NameCatalog NumberApplication
D-Fructose-6-phosphateF520-59PFKFB Assay
D-Glucose-6-phosphateF521-59PFKFB Assay

Bioreagents are crucial components in regular laboratory applications like enzyme assays. It is essential to use high-quality bioreagents to develop reliable assay methods and to generate reproducible and good-quality assay results. Our scientific team has over 100 years of combined research and industrial experience in the production of recombinant proteins and bioreagents. We leverage our expertise and experience to provide the global scientific community with the high quality and cost-effective bioreagents such as assay reagents, peptide substrates, oligo substrates, lipid substrates, siRNA reagents and more.

NameCatalog NumberFormulationGenBank IDSpecificity
14-3-3 alpha/beta siRNA Set IY71-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_00340414-3-3 alpha/beta siRNAs are designed to specifically knock-down human 14-3-3 alpha/beta expression.
14-3-3 epsilon siRNA Set IY75-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_00676114-3-3 epsilon siRNAs are designed to specifically knock-down human 14-3-3 epsilon expression.
14-3-3 sigma siRNA Set IY86-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_00614214-3-3 sigma siRNAs are designed to specifically knock-down human 14-3-3 sigma expression.
14-3-3 theta siRNA Set IY84-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_00682614-3-3 theta siRNAs are designed to specifically knock-down human 14-3-3 theta expression.
14-3-3 zeta siRNA Set IY92-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_00340614-3-3 zeta siRNAs are designed to specifically knock-down human 14-3-3 zeta expression.
4EBP1 siRNA Set IE35-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_0040954EBP1 siRNAs are designed to specifically knock-down human 4EBP1 expression.
AATK siRNA Set IA02-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_007377AATK siRNAs are designed to specifically knock-down human AATK expression.
ABL1 siRNA Set IA03-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_009594ABL1 siRNAs are designed to specifically knock-down human ABL1 expression.
ABL2 siRNA Set IA04-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_005158ABL2 siRNAs are designed to specifically knock-down human ABL2 expression.
ACK siRNA Set IA05-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_005781ACK siRNAs are designed to specifically knock-down human ACK expression.
ACVR2A siRNA Set IA35-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_001616ACVR2A siRNAs are designed to specifically knock-down human ACVR2A expression.
ACVR2B siRNA Set IA36-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_001106ACVR2B siRNAs are designed to specifically knock-down human ACVR2B expression.
ADD1 siRNA Set IA38-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_001119ADD1 siRNAs are designed to specifically knock-down human ADD1 expression.
AFX siRNA Set IA42-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_001170931AFX siRNAs are designed to specifically knock-down human AFX expression.
AKT1/PKB alpha siRNA Set IA16-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_005163AKT1/PKB alpha siRNAs are designed to specifically knock-down human AKT1/PKB alpha expression.
AKT2/PKB beta siRNA Set IA17-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_001626AKT2/PKB beta siRNAs are designed to specifically knock-down human AKT2/PKB beta expression.
AKT3 siRNA Set IA18-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_005465AKT3 siRNAs are designed to specifically knock-down human AKT3 expression.
ALK1 siRNA Set IA09-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_000020ALK1 siRNAs are designed to specifically knock-down human ALK1 expression.
ALK2 siRNA Set IA06-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_001105ALK2 siRNAs are designed to specifically knock-down human ALK2 expression.
ALK3 (BMPR1A) siRNA Set IB04-911The siRNAs are supplied as a lyophilized powder and shipped at room temperature.NM_004329ALK3 (BMPR1A) siRNAs are designed to specifically knock-down human ALK3 (BMPR1A) expression.
NameCatalog NumberFormulationPuritySequenceSpecificity
beta-Actin Positive Control siRNAA03-911DThe siRNAs are supplied as a lyophilized powder and shipped at room temperature.Single PAGE band5’-UGA AGA UCA AGA UCA UUG CdTdT-3’ and 5’-GCA AUG AUC UUG AUC UUC AdTdT-3’beta-Actin Positive Control siRNA is designed to specifically knock-down human beta-Actin expression.
Cy3 Labeled Negative Control siRNAS02-910NThe siRNAs are supplied as a lyophilized powder and shipped at room temperature.Cy3 Negative Control siRNA duplex resolves as a single band via PAGE5’-UUC UCC GAA CGU GUC ACG UTT-Cy3-3’ and 5’- ACG UGA CAC GUU CGG AGA ATT-3’
FAM Labeled Negative Control siRNAS03-910NThe siRNAs are supplied as a lyophilized powder and shipped at room temperature.≥ 90% by HPLC5’-UUC UCC GAA CGU GUC ACG UTT-FAM-3’ and 5’- ACG UGA CAC GUU CGG AGA ATT-3’
GAPDH Positive Control siRNAG13-911BThe siRNAs are supplied as a lyophilized powder and shipped at room temperature.Single PAGE band5’-GUG GAG AUU GUU GCC AUC AdTdT-3’ and 5’- UGA UGG CAA CAA UCU CCA CdTdT-3’GAPDH Positive Control siRNA is designed to specifically knock-down human GAPDH expression.
Unlabeled Negative Control siRNAS01-910NThe siRNAs are supplied as a lyophilized powder and shipped at room temperature.≥ 90% by HPLC5’-UUC UCC GAA CGU GUC ACG UTT-3’ and 5’-ACG UGA CAC GUU CGG AGA ATT-3’

COVID-19 Research Products (Proteins, Antibodies, ELISA and cDNA)

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Signalchem COVID-19

Research Solutions for Coronavirus – Signalchem

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First for Antibodies

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