SignalChem Lifesciences Corporation (“SLC”), headquartered in British Columbia, Canada, is a clinical-stage company developing novel targeted therapies for oncology.

Its unique business model has been built upon two important pillars: the Bioreagents and Research Services business and the Drug Discovery and Development business.

A group of scientists with extraordinary expertise and experience in kinase biology and drug discovery are working together cohesively to provide the best products and services to its customers around the world and to maximize the efficiency of its own drug discovery efforts.

Built on its expertise in developing kinase-focused cell signalling products and delivering discovery services for academia and pharmaceutical industry, SignalChem has uniquely positioned itself in the forefront of kinase inhibitor drug discovery.

Its advantages include, but not limited to, the largest and ever-growing repertoire of active kinases and mutant kinases, optimised activity-based assays on multiple assay platforms, broad interactions and partnership with leading pharmaceutical companies.


Product Categories

Research Areas

SignalChem’s product selection is available in the following areas of relevance for signalling proteins:

  • Akt / PKB Pathway
  • Apoptosis
  • Cancer
  • Cardiovascular Disease
  • Cell Cycle
  • Cellular Stress
  • Cytoskeletal Signaling
  • Death Receptor Signaling
  • Diabetes
  • DNA Damage
  • GPCR Pathway
  • Growth Factor Signalling
  • Heat Shock Signalling
  • Inflammation
  • Insulin Receptor Signalling
  • JAK-STAT Pathway
  • Lipid Signalling
  • MAPK / ERK Pathway
  • Neurobiology
  • NF-kB Pathway
  • p38 Pathway
  • PKC Signalling
  • SAPK/JNK Pathway
  • Ser / Thr Kinases
  • T & B Cell Receptor Signalling
  • Translational Control
  • Tyr Kinases
  • Wnt Signalling

SignalChem is a biotechnology company focused on the research, development and production of innovative cell signaling products to advance basic research and drug discovery efforts, with specific emphasis on the production of highly purified, biologically active, human recombinant proteins.

Cellular signalling or the mechanism by which a cell transmits its signals inwards, ultimately producing a specific biological response, is of fundamental clinical importance.  It is well documented that aberrations in these discrete pathways have been linked to the development of a variety of human diseases including cancer, cardiovascular disease, metabolic disorders, neurodegenerative disease and inflammatory conditions amongst others.

With the success of signal transduction inhibitors in the clinic, there is an intensive effort to identify targets linked with the pathogenesis of a human disease and to develop selective molecules to perturb these targets in an effort to improve patient prognosis and minimise the non-specific systemic side-effects associated with generalised treatment modalities.

The founders and scientific members of SignalChem have the knowledge to understand the architecture and biology of these discrete signalling pathways and to leverage this expertise to bring value-added products to the market.  SignalChem is emerging as a leader and a key contender in the life science recombinant protein market place.

SignalChem’s core product areas include active human protein kinases, active human protein phosphatases, unactive signalling proteins, assay kits and biologically relevant kinase and phosphatase substrates.

Discover how SignalChem’s Custom Services can make a difference in your research.

Our scientists understand how pivotal cell signaling proteins are for every research/drug discovery project to be successful, and we keep this principle in mind when collaborating with scientists wanting to procure fully functional, biologically active, custom made recombinant proteins serving their individual research needs.

Find out more below;

SCREENING HIGHLIGHTS

SignalChem’s compound selectivity profiling service determines the respective inhibitory profile and the putative mechanism of action. All compounds are profiled against a panel of targets either using an individual dose, a single concentration or at multiple concentrations in order to allow in-depth IC50 determinations. In addition, the protein kinase assays can be performed under varying ATP concentrations to evaluate the competitive effects of ATP.

 

The compound selectivity profiling service offered by SignalChem is a very economical and convenient approach to the drug discovery continuum with a two-week turnaround of your specific profiling results. Compounds can be supplied by the client as DMSO stocks of known concentration, as solid material in vials.

Figure 1: Compound Selectivity Profiling Against 48 Targets available as part of SignalChem’s Compound Profiling Service.

Figure 2: The IC50 value of a compound was determined by plotting the log of the concentration of the compound vs. the % inhibition of the kinase.

TARGET CATEGORIES

Restrictions

JAK2*: Patent restrictions on this product exclude it as a profiling target for US customers.


Confidentiality

SignalChem maintains all information under the strictest confidentiality. All information and/or materials supplied by the customer will be used as directed by the client. Upon completion of the project, all materials will be either returned to the client or disposed of accordingly. SignalChem is willing to execute confidentiality agreements with its clients.

SignalChem scientists have gained extensive experience in manufacturing highly functional cellular signaling proteins including protein kinases, protein phosphatases and cellular protein substrates, among others.

Depending upon the client’s needs, SignalChem will work with you to custom develop the target to your desired specifications within a realistic and suitable timeframe. Our products have successfully been used in various applications including high-throughput screening, activity assays, binding assays, cell-based assays, protein-protein interaction studies, structural studies and more.

OUR CUSTOM PROTEIN DEVELOPMENT CAPABILITIES

  • Production of the full-length or truncated form of the desired targets
  • Production of highly purified proteins in desired final formulation
  • Production of the target as either untagged or tagged proteins
  • Production of the targets with high biological activity
  • Production of proteins from μg to mg scale

STEP-WISE STRATEGY FOR DEVELOPMENT OF CUSTOM PROTEINS FOR CLIENTS

Cloning of Target Gene

Based on the target gene, SignalChem scientists will design specific primers against the target of interest and amplify the gene product from cDNA libraries derived from various human cell lines.The cloned target gene is subsequently cloned into the appropriate expression vectors to maximize the expression levels of the desired target.

Expression of Desired Protein

Based upon the respective needs of the client, SignalChem scientists will recommend the most suitable expression system to use and as a part of the custom project. The choice of the cells and the expression systems is governed by the level of post-translational modification required and whether enzymatic activity is essential.

Purification & Additional Modification of Protein

The selected target is purified from the cellular lysate using established protocols to maintain the protein structure and activity. Additional steps will be taken based on the client’s requirements including phosphorylation/dephosphorylation, tag removal, concentration increase, buffer exchange, and more.

Characterization of Target Protein

In the final stages of development, the protein product will be evaluated in multiple tests to ensure the concentration, purity, and activity meet the specifications set by the client.

Confidentiality

SignalChem maintains all information under the strictest confidentiality. All information and/or materials supplied by the customer will be used as directed by the client. Upon completion of the project, all materials will be either returned to the client or disposed of accordingly. SignalChem is willing to execute confidentiality agreements with its clients.

Recombinant antibodies (rAbs) are highly specific biochemical probes, which are gaining popularity for use in life sciences research, diagnostics and clinical therapy. Unlike traditional monoclonal antibodies (mAbs), rAbs are generated in vitro using synthetic genes, and do not require the use or harm to animals during the production process. Due to continuous interest and high demand, more and more rAb sequences are becoming available to give researchers a growing library of affinity probe designs to choose from.

SignalChem is leveraging our years of expertise to produce high-purity recombinant proteins in various cell systems to provide custom recombinant antibody production services.

 

SIGNALCHEM’S CUSTOM rAb PRODUCTION SERVICE

SEQUENCE DESIGN

Confidentiality

SignalChem maintains all information under the strictest confidentiality. All information and/or materials supplied by the customer will be used as directed by the client. Upon completion of the project, all materials will be either returned to the client or disposed of accordingly. SignalChem is willing to execute confidentiality agreements with its clients.

Protein Kinases are a family of pivotal enzymes with 518 members implicated in various cell signaling pathways, constituting over 2% of the human genome. Kinases exert their roles by phosphorylating their respective physiological substrates. They catalyze the transfer of γ-phosphate from ATP or GTP to the hydroxyl groups of serine, threonine and tyrosine residues on the substrate proteins or the glycosyl moieties in lipids. Deregulation of Kinase could lead to the changes in enzymatic activity and/or expression, subcellular localization, the stability of kinase, protein-protein interactions. Aberrant regulation of Kinase-mediated signaling pathways is responsible for all major human pathological conditions such as cancer, cardiovascular disease, neurodegenerative diseases and metabolic disorders.

SignalChem offers a broad range of recombinant protein and lipid Kinases of superior purity and activity to assist the global academic research and drug discovery efforts with the focus on Kinases. Its active Kinase product line is one of the most comprehensive in the world in terms of the coverage and has been utilized by many pharmaceutical companies in their drug discovery programs. An in-house product development team with over 100 years of combined experience in Kinase biochemistry is behind the production and quality control of all the Kinase-related products as well as assay development.

Protein phosphorylation is a reversible post-translational modification carried out by two families of enzymes, Protein Kinases and Protein Phosphatases. The interplay between these two families of enzymes is responsible for modulating the phosphorylation state of their physiological substrates, and thereby their activities, subcellular localization and interactions with other proteins. Similar to Protein Kinases, Protein Phosphatases play pivotal roles in a myriad of biological processes including cell growth, proliferation, survival, and apoptosis. Protein Phosphatases are broadly categorized according to specific amino acids they dephosphorylate into two major families: protein serine/threonine phosphatases, and protein tyrosine phosphatases, which also include the dual-specificity phosphatases.

SignalChem, with comprehensive active Protein Kinase product line, has utilized our expertise in the recombinant protein production to manufacture biologically active phosphatases including PP1s, PP2s, PTPNs, and more. An in-house product development team with over 100 years of combined experience in protein biochemistry is behind the production and quality control of all the phosphatases as well as the method development for their activity assays. We aim to manufacture our phosphatases with superior quality and activity to facilitate and assist the global research and drug discovery efforts aiding human health.

Name Catalog Number Species Tag Expression System Sequence Genbank Number
CDC25A, Active C04-20G Human GST Sf9 insect cells using baculovirus Full Length NM_001789
CDC25B, Active C04-20BG Human GST Sf9 insect cells using baculovirus Full Length NM_021873
CDC25C, Active C04-20CG Human GST Sf9 insect cells using baculovirus Full Length BC019089
DUSP22 (MKPX), Active D22-20G Human GST E.coli Full Length NM_020185
PP1A, Active P13-20G Human GST Sf9 insect cells using baculovirus Full Length NM_002708
PP1A, Active P13-20GH Human GST E.coli Full length NM_002708
PP1B, Active P14-20G Human GST Sf9 insect cells using baculovirus Full Length NM_002709
PP2A alpha/PPP2R1A Complex, Active P16-20BH Human HIS Sf9 insect cells using baculovirus Full Length NM_002715
PP2Aα/PPP2R1A Complex, Active P16-20BG Human GST Sf9 insect cells using baculovirus Full length NM_002715
PP2Calpha, Active P02-20G Human GST Sf9 insect cells using baculovirus Full Length NM_021003
PP2Calpha, Active P02-20BG Human GST E.coli Full Length NM_021003
PP2Cgamma, Active P07-20G Human GST Sf9 insect cells using baculovirus Full Length NM_177983
PTEN, Active P23-20G Human GST E.coli Full Length NM_000314
PTEN, Active T03-20H Human HIS Sf9 insect cells using baculovirus Full length NM_000314
PTPN1 (PTP1B), Active P28-20G Human GST Sf9 insect cells using baculovirus Full Length NM_002827
PTPN11 (SHP2), Active P38-21G Human GST E.coli 246-593 NM_002834
PTPN11 (SHP2), Active P38-20G Human GST Sf9 insect cells using baculovirus Full Length NM_002834
PTPN11 (T253M Q257L), Active P38-22G Human GST Sf9 insect cells using baculovirus Full Length NM_002834
PTPN12 (PTP-PEST), Active P39-21G Human GST E.coli 1-355 NM_002835
PTPN13 (FAP-1), Active P40-21G Human GST E.coli 2169-2485 NM_080683
PTPN2 (TC-PTP), Active P29-20G Human GST E.coli Full Length NM_080422
PTPN6 (SHP1), Active P33-20G Human GST E.coli Full Length NM_080548
PTPN6 (SHP1), Active P33-20H Human HIS E.coli Full Length NM_0080548
PTPN7 (LC-PTP), Active P34-20G Human GST E.coli Full Length NM_002832
PTPRA (LRP), Active P48-21G Human GST E.coli 174-802 NM_002836
PTPRB, Active P49-21G Human GST Sf9 insect cells using baculovirus 1552-end NM_002837
PTPRC (CD45), Active P50-21H Human HIS Sf9 insect cells using baculovirus 604-end NM_002838
PTPRC (CD45), Active P50-21BG Mouse GST E.coli 592-end NM_001111316
PTPRE, Active P52-21G Human GST Sf9 insect cells using baculovirus 75-end BC050062
PTPRF (LAR), Active P53-21G Human GST E.coli 1275-1897 NM_002840
PTPRJ (CD148), Active P56-21G Human GST Sf9 insect cells using baculovirus Full Length NM_002843
PTPRS (PTP- sigma), Active P64-21G Human GST E.coli 883-1210 NM_130855
SHIP1, Active P08-20G Human GST Sf9 insect cells using baculovirus Full Length NM_005541
SHIP2, Active P09-20G Human GST Sf9 insect cells using baculovirus Full Length NM_001567
WIP1, Active P04-20G Human GST Sf9 insect cells using baculovirus Full length BC016480

Epigenetic enzymes are crucial in maintaining key cellular functions by modifying chromatin structures and controlling gene transcription process. These reversible epigenetic DNA and histone modifications are controlled by important epigenetic enzymes such as methyltransferases and acetyltransferases. Dysregulation of these enzymes have been observed in myriad human diseases such as cancer. In recent years, epigenetic enzymes have emerged as some of the most promising classes of targets for drug discovery projects and development projects.

Scientists at SignalChem have developed a full range of epigenetic enzymes including acetyltransferases, histone deacetylases, methyltransferases and more. Our high-quality recombinant epigenetic enzymes and the assay methods are valuable tools for scientists to conduct research in epigenetics and for the pharmaceutical companies to develop novel therapeutics modulating these biological targets.

Name Catalog Number Species Tag Expression System Sequence Genbank Number
ASH2L Protein A372-30BG Human GST E.coli Full Length BC015936
BRD3 Protein B17-30G Human GST Sf9 insect cells using baculovirus Full Length NM_007371
DNMT1 Protein D351-31G Mouse GST Sf9 insect cells using baculovirus 766-end BC053047
DPY30 Protein D369-30H Human HIS E.coli Full Length NM_032574
EED Protein E310-30H Human HIS E.coli Full Length BC068995
EZH1 Protein E395-30G Human GST Sf9 insect cells using baculovirus Full Length BC015882
EZH2 (Y641C) Protein E396-32BG Human GST Sf9 insect cells using baculovirus Full Length BC010858
EZH2 (Y641H) Protein E396-32DG Human GST Sf9 insect cells using baculovirus Full Length BC010858
EZH2 (Y641N) Protein E396-32EG Human GST Sf9 insect cells using baculovirus Full-Length BC010858
EZH2 (Y641S) Protein E396-32FG Human GST Sf9 insect cells using baculovirus Full-Length BC010858
EZH2 Protein E396-30G Human GST Sf9 insect cells using baculovirus Full Length BC010858
HEMK1 Protein H311-30G Human GST Sf9 insect cells using baculovirus Full-Length NM_016173
KAT3A (CREBBP) Protein K312-31G Human GST Sf9 insect cells using baculovirus 518-1207 NM_004380
KAT3B (EP300) Protein K312-31BG Human GST Sf9 insect cells using baculovirus 532-1153; contains the catalytic domain NM_001429
KAT4 Protein K313-31G Human GST Sf9 insect cells using baculovirus 1032-end NM_138923
KAT8 (MYST1) Protein K317-31G Human GST Sf9 insect cells using baculovirus 2-467 BC037773
KAT9 (ELP3) Protein K318-30G Human GST Sf9 insect cells using baculovirus Full Length NM_018091
LCMT2 Protein L322-30G Human GST Sf9 insect cells using baculovirus Full Length NM_014793
MEP50 (WDR77) Protein W329-30G Human GST Sf9 insect cells using baculovirus Full Length BC001679
METTL1 Protein M321-30G Human GST Sf9 insect cells using baculovirus Full Length NM_005371
METTL11A Protein M331-30G Human GST Sf9 insect cells using baculovirus Full Length BC001396
METTL14 Protein M334-30G Human GST Sf9 insect cells using baculovirus Full Length NM_020961
METTL2A Protein M322-30G Human GST Sf9 insect cells using baculovirus Full Length NM_181725
METTL3 Protein M323-30G Human GST Sf9 insect cells using baculovirus Full Length NM_019852
MGMT Protein M354-30H Human HIS Sf9 insect cells using baculovirus Full Length BC000824
P300 Protein P07-31G Human GST Sf9 insect cells using baculovirus 1283-1673 NM_001429
PCAF Protein P09-31G Human GST E.coli 431-end NM_003884
PCMT1 Protein P314-30G Human GST Sf9 insect cells using baculovirus 2-end BC007501
PCNA Protein P11-30H Human HIS E.coli Full Length NM_002592
PRDM2 (KMT8) Protein P333-31G Human GST Sf9 insect cells using baculovirus 1-340 NM_012231
PRMT2 Protein P365-30BG Human GST Sf9 insect cells using baculovirus Full Length BC000727
PRMT5 Protein P365-30EG Human GST Sf9 insect cells using baculovirus Full Length NM_006109
PRMT7 Protein P365-30GG Human GST Sf9 insect cells using baculovirus Full Length BC000146
RBBP4 Protein R314-30G Human GST Sf9 insect cells using baculovirus Full Length BC075836
RBBP5 Protein R315-30H Human HIS E.coli Full Length NM_005057
SETD4 Protein S353-30G Human GST Sf9 insect cells using baculovirus Full Length BC002898
SETD8 Protein S345-30G Human GST Sf9 insect cells using baculovirus Full Length BC050346
SETDB1 (KMT1E) Protein S346-31G Human GST Sf9 insect cells using baculovirus 715-end BC028671
SETDB2 Protein S346-30BG Human GST Sf9 insect cells using baculovirus Full Length BC047434
SETMAR Protein S347-30G Human GST Sf9 insect cells using baculovirus Full Length BC011635
TRDMT1 (DNMT2) Protein T352-30G Human GST Sf9 insect cells using baculovirus Full Length BC047733
WDR5 Protein W325-30H Human HIS E.coli Full Length BC001635
WHSC1L1 (NSD3) Protein N378-31G Human GST Sf9 insect cells using baculovirus 1038-end BC113469
WTAP Protein W369-30G Human GST Sf9 insect cells using baculovirus Full Length NM_004906

Protein modifications by ubiquitin (Ub) or ubiquitin-like proteins (UBLs) participate in many critical cellular processes such as cell-cycle regulation, DNA repair, oncogenesis, antiviral pathways and most notably, proteasomal degradation of target proteins. Ubiquitination and modification by UBLs share a similar catalytic cascade which requires the sequential action of three classes of enzymes: E1 activating enzymes, E2 conjugating enzymes, and E3 ligases. Research has linked dysregulation of the Ub/UBLs modification system to numerous diseases including cancer, immunological disorders, and neurodegeneration. Thus, the high substrate specificity provided by combinations of over 30 E2’s and over 600 E3’s makes these enzymes emerging drug targets.

In response to growing market demand, SignalChem has developed an extensive array of products encompassing ubiquitin proteins and active enzymes, Ub/UBL modifiers, and substrates in the ubiquitination, SUMOylation, ISGylation and NEDDylation processes. Using Promega’s AMP-Glo™ technology and an optimized assay protocol, we have identified and validated a variety of functional combinations of the enzyme components. With the established protocol, each enzyme in the catalytic cascade has been assessed for their activity towards the generation of free AMP. In addition, inhibition profiles of the ubiquitinating enzymes have been obtained using the assay system, further demonstrating their potential to be used in high-throughput screening to identify lead compounds for drug discovery and development programs.

Name Catalog Number Species Tag Expression System Sequence Genbank Number
SAE1/UBA2 Complex, Active U208-380G Human His/GST Sf9 insect cells using baculovirus Full Length NM_005500
UBA1 (UBE1), Active U201-380G Human GST Sf9 insect cells using baculovirus Full Length NM_003334
UBA6, Active U206-380G Human GST Sf9 insect cells using baculovirus Full Length AL832458
UBA7(UBE1L), Active U207-380G Human GST Sf9 insect cells using baculovirus Full Length NM_003335
UBA2 (SAE2) Protein U202-30G Human GST Sf9 insect cells using baculovirus Full Length NM_005499
UBA3 (UBE1C) Protein U203-30G Human GST Sf9 insect cells using baculovirus Full Length BC022853
UBLE1A (SAE1) Protein U208-30G Human GST Sf9 insect cells using baculovirus Full Length NM_005500

Post-translational modification of cellular proteins plays a crucial role in cell survival, cell signaling and overall maintenance of cellular health. Citrullination is one of the many crucial protein modifications catalyzed by a family of enzymes called Protein Arginine Deiminases (PADs). PADs catalyze the hydrolysis of peptidyl-arginine to form peptidyl-citrulline on important cellular proteins such as histones, thereby regulating multiple cell signaling pathways, and biochemical processes.

The PAD family consists of five members of calcium-dependent isozymes PAD1, 2, 3, 4, and 6. Citrullination or hypercitrullination of proteins induces a structural change, modifying their biological function and their interaction mechanisms with other cellular proteins. Because of this property, numerous notable studies have established PADs as an important class of targets for drug discovery projects related to many human diseases such as cancer, autoimmune diseases (rheumatoid arthritis), and neurodegeneration.

SignalChem’s scientists have produced all five high-quality recombinant mammalian PADs and have developed sensitive and reliable PAD assay cocktails to facilitate your drug discovery and development research. These are effective in vitro tools to investigate protein citrullination in various human diseases.

Name Catalog Number Species Tag Expression System Sequence Genbank Number
PAD Cocktail, Active P312-37C GST Sf9 insect cells using baculovirus Full Length NM_013358 (PAD1)
PAD1, Active P312-310G Human GST Sf9 insect cells using baculovirus Full length NM_013358
PAD2, Active P312-310BG Mouse GST Sf9 insect cells using baculovirus Full length BC049947
PAD2, Active P312-318BG Human GST Sf9 insect cells using baculovirus Full length NM_007365
PAD3, Active P312-310CG Human GST Sf9 insect cells using baculovirus Full length NM_016233
PAD4, Active P312-310DG Human GST Sf9 insect cells using baculovirus Full length BC025718
PAD6 Protein P312-30FG Human GST Sf9 insect cells using baculovirus Full Length NM_207421

ATPases and GTPases are two different families of hydrolase enzymes that catalyze the hydrolysis of the third phosphate of ATP and GTP into ADP and GDP respectively. While human ATPases mainly facilitate the transport of cellular metabolites by harnessing the energy released from the ATP hydrolysis, the GTPases conventionally act as “molecular switches” that are essential mediators of signal transduction in the cells. Dephosphorylation of ATP and GTP is an important chemical process in all forms of life, therefore ATPases and GTPases are spread ubiquitously across the plant and the animal kingdom. Mutations in members of these families of enzymes have been observed in many human diseases such as cancer and metabolic disorders. For example, the founding member of the small GTPase Superfamily, Ras, is mutated in about 15% of all human tumors.

SignalChem manufactures high-quality active GTPase and ATPase enzymes such as G protein α subunits, Ras, Rac, and Rho. Our recombinant ATPases/GTPases are perfect candidates to be included in enzyme activity assays and their inhibitor profiling studies. SignalChem’s active GTPases are tested exclusively using Promega’s GTPase-Glo™ Assay.

Name Catalog Number Species Tag Expression System Sequence Genbank Number
CDC42, Active C108-310GH Human GST/HIS E.coli Full Length NM_001791
GNAI1, Active G121-310G Human GST E.coli 2-end NM_002069
GNAI2, Active G122-310G Human GST E.coli 2-end NM_002070
GNAI3, Active G123-310G Human GST E.coli 2-end NM_006496
GNAS, Active G127-310G Human GST E.coli Full Length NM_000516
HRAS1 (Mature form), Active R105-310H Human HIS E.coli 2-186 NM_005343
KRAS (Mature form), Active R106-310H Human HIS E.coli 2-186 NM_033360
NRAS (Mature form), Active R107-310H Human HIS E.coli 1-186 NM_002524
RAC1, Active R103-310G Human GST E.coli Full Length NM_006908
RAC2, Active R104-310H Human HIS E.coli Full Length NM_002872
RAC3, Active R102-310H Human HIS E.coli Full Length NM_005052
RhoA (Mature form), Active R144-310H Human HIS E.coli 1-190 NM_001664
RhoC (Mature form), Active R144-310CH Human HIS E.coli 1-190 NM_175744
RhoD (Mature form), Active R144-310DH Human HIS E.coli 1-207 BC001338
VCP, Active V116-310G Human GST Sf9 insect cells using baculovirus Full Length NM_007126

Phosphodiesterases (PDEs) play a central role in the regulation of various signaling cascades by specifically hydrolyzing the cyclic nucleotides, cAMP, and cGMP into their nucleoside 5’ -– monophosphate form AMP and GMP respectively. Hydrolysis of these nucleotides results in the breakdown of these secondary messengers and the abrogation of downstream signaling. Given the importance of these enzymes in the regulation of cAMP/cGMP signaling, PDEs have been identified as an important class of potential drug targets in diseases such as cancer, neurodegeneration, coronary heart diseases, asthma and more.

Signalchem has successfully manufactured 19 of the 24 phosphodiesterases from the human genome as active enzymes. Our recombinant PDEs are compatible with their substrates cAMP and cGMP and are ready to be included in enzyme activity and inhibitor profiling assays. Our PDEs are tested exclusively using Promega’s PDE-Glo™ Assay technology.

Name Catalog Number Species Tag Expression System Sequence Genbank Number
PDE10A, Active P98-31G Human GST Sf9 insect cells using baculovirus 71-end NM_006661
PDE1A, Active P89-30H Human HIS Sf9 insect cells using baculovirus Full Length NM_005019
PDE1B, Active P89-30BG Human GST Sf9 insect cells using baculovirus Full Length NM_000924
PDE1C, Active P89-30CG Human GST Sf9 insect cells using baculovirus Full Length NM_005020
PDE2A, Active P90-30G Human GST Sf9 insect cells using baculovirus Full Length NM_002599
PDE3A, Active P91-31G Human GST Sf9 insect cells using baculovirus 669-end NM_000921
PDE3B, Active P91-31BG Human GST Sf9 insect cells using baculovirus 654-end NM_000922
PDE4A, Active P92-31G Human GST Sf9 insect cells using baculovirus 332-end NM_001111307
PDE4B, Active P92-31BG Human GST Sf9 insect cells using baculovirus 305-end NM_002600
PDE4C, Active P92-31CG Human GST Sf9 insect cells using baculovirus 287-end NM_000923
PDE4D, Active P92-31DG Human GST Sf9 insect cells using baculovirus 225-end NM_006203
PDE5A, Active P93-31G Human GST Sf9 insect cells using baculovirus 537-end NM_001083
PDE6A, Active P94-31G Human GST Sf9 insect cells using baculovirus 31-end NM_000440
PDE6B, Active P94-30BG Human GST Sf9 insect cells using baculovirus Full Length NM_000283
PDE7A, Active P95-31G Human GST Sf9 insect cells using baculovirus 104-end NM_002603
PDE7B, Active P95-30BG Human GST Sf9 insect cells using baculovirus Full Length NM_018945
PDE8A, Active P96-30G Human GST Sf9 insect cells using baculovirus Full Length NM_002605
PDE8B, Active P96-31BG Human GST Sf9 insect cells using baculovirus 113-end NM_003719
PDE9A, Active P97-30G Human GST Sf9 insect cells using baculovirus Full Length NM_001001567

High-quality recombinant proteins are crucial for life science research and drug discovery projects. SignalChem offers a broad range of recombinant proteins including Dihydropyrimidinase, Dioxygenases, lysyl oxidases, superoxide dismutases, and phospholipase C of superior purity. Our in-house team with over 100 years of combined experience in recombinant protein biochemistry stands behind the production and quality of one of the most comprehensive recombinant protein product line in the world.

Name Catalog Number Species Tag Expression System Sequence Genbank Number
DPYSL2 Protein D470-30BG Human GST Sf9 insect cells using baculovirus Full Length BC056408

SignalChem’s 2019-nCoV (SARS-CoV-2) ELISA kits are important research and detection tools to study the novel SARS-CoV-2 and its molecular interactions with the host cell. Our high-quality ELISA kits can be used for the detection and quantification of SARS-CoV-2 spike protein (RBD) and human anti-SARS-CoV-2 spike protein IgG in biological and recombinant samples.

Catalogue Number Product Name
C19SD-876 2019-nCoV S1 Protein ELISA Kit
C19S1-877 2019-nCoV S1 Human IgG ELISA Kit
C19S1-A877 2019-nCoV S1 Human IgA ELISA Kit
C19S1-M877 2019-nCoV S1 Human IgM ELISA Kit
C19S1-P877 2019-nCoV S1 Human IgG-IgA-IgM ELISA Kit
C19NS1-P877 2019-nCoV N-S1 Human IgG-IgA-IgM ELISA Kit
C19NS1-A877 2019-nCoV N-S1 Human IgA ELISA Kit
C19NS1-M877 2019-nCoV N-S1 Human IgM ELISA Kit
C19NS1-877 2019-nCoV N-S1 Human IgG ELISA Kit

Detection Kits

Catalogue Number Product Name
P312-863 PAD Detection Kit
P312-863-C PAD Detection Kit

Inhibitor Screening Kits

Catalogue Number Product Name
P37C-863 PAD Cocktail Inhibitor Screening Kit
P318BG-863 PAD2 (human) Inhibitor Screening Kit
P310G-863 PAD1 Inhibitor Screening Kit
P310DG-863 PAD4 Inhibitor Screening Kit
P310CG-863 PAD3 Inhibitor Screening Kit
P310BG-863 PAD2 (mouse) Inhibitor Screening Kit

SignalChem understands how important it is for the researchers to source high-quality antibodies while working on research projects involving new proteins and other antigens of interest. SignalChem offers a comprehensive range of polyclonal and monoclonal antibodies including primary & secondary antibodies, paralog-specific antibodies, modification antibodies, phospho-specific antibodies, and tag antibodies to support life science research. We also work with scientists to develop custom recombinant antibodies in various cell systems, ready to be used in different immunoassays.

Name Catalog Number Host Cited Application Immunogen
Anti-DYKDDDDK F51-61M Mouse, IgG2b, FG4R WB, ELISA, IP, IS DYKDDDDK peptide conjugated to KLH
Anti-DYKDDDDK F51-63R Rabbit WB DYKDDDDK peptide conjugated to KLH
Anti-GFP G46-60M Mouse, IgG1, GF28R WB GFP N-terminal peptide with KLH conjugate from Aequorea Victoria Jellyfish
Anti-GST G52-61M Mouse, IgG2a, G2R WB Purified GST
Anti-HA H98-61M Mouse, IgG3, C10 WB, ELISA, IP, IS
Anti-HA H98-63R Rabbit Polyclonal WB, ELISA, IP, IS
Anti-His H99-61M Mouse, IgG2b, EH158 WB, ELISA, IP, IS HHHHHH peptide conjugated to KLH
Anti-His H99-63R Rabbit WB, ELISA, IP, IS
Anti-Myc M86-61M Mouse, IgG1, M19 WB, ELISA, IP, IS EQKLISEED peptide conjugated to KLH
Anti-RFP R46-61M Mouse, IgG1, RF5R WB RFP from the Discosoma sea anemone N-terminal peptide-KLH conjugates
Anti-V5 V05-61M Mouse, IgG1, V4RR WB, ELISA, IP, IS GKPIPNPLLGLDST peptide conjugated to KLH
Name Catalog Number Host Cited Application Immunogen
Anti-4EBP1 E35-563R Rabbit, IgG WB, ELISA, ICC 4EBP1 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human 4EBP1
Anti-ADD1 A38-63R Rabbit WB Synthetic peptide corresponding to amino acids 724-728 of human ADD1 (P35611)
Anti-AFX A42-63R Rabbit WB Synthetic peptide corresponding to amino acids 195-199 of human AFX
Anti-AKT (pan) A16-63R Rabbit WB Synthetic peptide corresponding to amino acids 471-475 of human AKT
Anti-AKT (pan) A16-63BR Rabbit WB Synthetic peptide corresponding to amino acids 313-317 of human AKT1 (protein accession number P31749)
Anti-AKT1 A16-60M Mouse, Monoclonal, 9A4 WB Recombinant full length active AKT1 protein
Anti-AKT1 A16-63CR Rabbit, IgG WB, ELISA, IF, IHC AKT1 antibody was raised against a 16 amino acid synthetic peptide from near the amino-terminus of human AKT1
Anti-AKT2 A17-61A Rat, IgG2a ELISA, IHC, WB The antibody was produced against synthesized peptide corresponding to internal residues of the human AKT2 protein.
Anti-AKT2/3 A17-63BR Rabbit WB Protein Code: P31751
Anti-AKT3 A18-61M Mouse, IgG1 ELISA, IHC, WB The antibody was produced against synthesized peptide corresponding to internal residues of the human AKT3 protein.
Anti-ALK2 A06-63R Rabbit, IgG WB, ELISA ALK2 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of the human ALK2
Anti-ALK4 A07-63R Rabbit, IgG WB, ELISA ALK4 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human ALK4
Anti-ALK7 A08-63R Rabbit, IgG WB, ELISA ALK7 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of the human ALK7
Anti-alpha 1-Actin A03-360M Mouse, IgG1, C4 WB, IF, IHC Chicken gizzard actin
Anti-AMPK alpha 1/2 P47-63BR Rabbit WB Synthetic peptide corresponding to amino acids 170-174 of human AMPK
Anti-Amyloid beta A06-563R Rabbit, IgG WB, ELISA, IF, IHC Amyloid beta antibody was raised against a synthetic peptide corresponding to the amino terminus (aa 1-14) of human beta amyloid conjugated to KLH using maleimide.
Anti-AOS1 A80-63R Rabbit WB Synthetic peptide of c-terminal amino acid sequence of human AOS1 (Q9UBE0)
Anti-APBA1 A86-363R Rabbit, IgG WB Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH
Anti-APC1 A87-363R Rabbit, IgG WB, ELISA, IHC APC1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human APC1
Anti-APC1 (Ser355) A87-363BR Rabbit, IgG ELISA, IP, WB The antibody was produced against synthesized peptide corresponding to amino acids 351-359 of Human APC1.
Name Catalog Number Host Cited Application Immunogen
Anti-GOAT, HRP Conjugated G34-62DC Chicken, IgG Ideal working dilutions for each application should be empirically determined by the investigator. The antibody was produced against goat IgG whole molecule
Anti-Mouse HRP G32-62G Goat Polyclonal WB, ELISA Affinity purified mouse immunoglobulins
Anti-MOUSE, AP Conjugated M32-62ER Rabbit, IgG IHC, ELISA, WB (Ideal working dilutions for each application should be empirically determined by the investigator.) The antibody was produced against mouse IgG whole molecule
Anti-MOUSE, Biotin Conjugated M32-62BG Goat, IgG WB, ELISA, IHC (Ideal working dilutions for each application should be empirically determined by the investigator.) The antibody was produced against mouse IgG whole molecule in goat.
Anti-MOUSE, Fluorescein Conjugated M32-62CG Goat, IgG ELISA, IF Microscopy, Flow Cytometry (Ideal working dilutions for each application should be empirically determined by the investigator.) The antibody was produced against mouse IgG whole molecule.
Anti-MOUSE, Rhodamine Conjugate M32-62FG Goat, IgG ELISA, Flow Cytometry, IF Microscopy (Ideal working dilutions for each application should be empirically determined by the investigator.) The antibody was produced against mouse IgG whole molecule.
Anti-Rabbit HRP G33-62G Goat Polyclonal WB, ELISA Affinity purified rabbit immunoglobulins
Anti-RABBIT, AP Conjugated R33-62EG Goat, IgG ELISA, IHC, WB (Ideal working dilutions for each application should be empirically determined by the investigator.) The antibody was produced against Rabbit IgG whole molecule in goat.
Anti-RABBIT, Biotin Conjugated R33-62BG Rabbit, IgG ELISA, IHC, WB (Ideal working dilutions for each application should be empirically determined by the investigator.) The antibody was produced against Rabbit IgG whole molecule in goats
Anti-RABBIT, Fluorescein Conjugated R33-62CG Goat, IgG ELISA, Flow Cytometry, IF Microscopy (Ideal working dilutions for each application should be empirically determined by the investigator.) The antibody was produced against Rabbit IgG whole molecule
Anti-RABBIT, Rhodamine Conjugated R33-62FG Goat, IgG FLISA, FC, IF (Ideal working dilutions for each application should be empirically determined by the investigator.) The antibody was produced against Rabbit IgG whole molecule.
Anti-RAT, HRP Conjugated A37-62DG Goat, IgG ELISA, IHC, WB (Ideal working dilutions for each application should be empirically determined by the investigator.) The antibody was produced against rat IgG whole molecule.
Anti-SHEEP, HRP Conjugated S36-62DD Donkey, IgG ELISA, IHC. WB (Ideal working dilutions for each application should be empirically determined by the investigator.) The antibody was produced against synthesized Sheep IgG whole molecule in donkey.
Name Catalogue Number Host Cited Application Immunogen
Anti-AKT3 A18-63R Rabbit WB Protein Code: Q9Y243
Anti-AMPK alpha 1 P47-63R Rabbit WB Synthetic peptide corresponding to amino acids 483-487 of human AMPKα
Anti-CAMK1 C07-60M Mouse, IgG1, 5H8 WB Human recombinant full length CAMK1 protein
Anti-CHK2 C48-60M Mouse, IgG1, 7F9 WB Human full length recombinant CHK1
Anti-ERK1 M29-60M Mouse, IgG1, E32 WB, IP Recombinant full length ERK1 protein
Anti-ERK1 M29-60BM Mouse, IgG1, E19 WB, IP Recombinant full length ERK1 protein
Anti-GSK3 alpha G08-63R Rabbit WB Protein Code P49840
Anti-GSK3 beta G09-60M Mouse, IgG1, 6C2 WB Recombinant full length active GSK3β protein
Anti-HSP90 beta H36-63R Rabbit WB Synthetic peptide corresponding to amino acids 252-256 of human HSP90β
Anti-JAK2 J02-63R Rabbit WB Synthetic peptide corresponding to amino acids 1005-1009 of human JAK2
Anti-JNK1 M33-63R Rabbit WB Protein Code: P45983
Anti-JNK2 M34-60M Mouse, IgG2, 2G12 WB, IP Human recombinant full length JNK2 protein
Anti-MEK1 M02-60M Mouse, IgG1, 7F1 WB, IP Recombinant full length humanMEK1 protein
Anti-MEK2 M03-63R Rabbit WB Synthetic peptide corresponding to amino acids 392-396 of human MEK2
Anti-p38 alpha M39-63R Rabbit WB C-terminal peptide of p38α conjugated to ovalbumin
Anti-p38 beta M36-63R Rabbit WB C-terminal peptide of p38β conjugated to ovalbumin
Anti-p38 gamma M37-63R Rabbit WB C-terminal peptide of p38γ conjugated to ovalbumin
Anti-PAK1 P02-63R Rabbit WB Synthetic peptide corresponding to amino acids 210-214 of human PAK1
Anti-PKC delta P64-63R Rabbit WB Synthetic peptide corresponding to amino acids 643-647 of human PKCδ
Anti-PKC delta P64-63CR Rabbit WB Synthesized peptide derived from C-terminus of human PKCδ protein
Anti-PKC mu P72-63R Rabbit WB Synthetic peptide corresponding to amino acids 736-740 of human PKCμ
Anti-PKC theta P74-63R Rabbit WB Synthetic peptide corresponding to amino acids 674-678 of human PKCθ
Anti-SMAD2 S11-63R Rabbit WB Synthetic peptide corresponding to amino acids 218-222 of human SMAD2
Anti-STAT1 S52-63R Rabbit WB Synthetic peptide corresponding to amino acids 699-703 of human STAT1
Anti-STAT3 S54-63BR Rabbit WB, IP Synthetic peptide corresponding to amino acids 725-729 of human STAT3
Anti-STAT3 S54-63R Rabbit WB Protein Code: P40763
Anti-STAT4 S55-63R Rabbit WB Synthetic peptide corresponding to amino acids 691-695 of human STAT4
Anti-STAT5 S56-63R Rabbit WB Protein Code: P42229
Anti-STAT5 S56-63BR Rabbit WB Synthetic peptide corresponding to amino acids 692-696 of human STAT5 (protein accession number P42229)
Name Catalogue Number Host Cited Application Immunogen
Anti-5-Methylated Cytosine (5-methyl cytosine) C92-67S Sheep, IgG WB, IP 5-Methylated Cytosine (5-methyl cytosine)
Anti-Acetylated Lysine L95-66R Rabbit WB, ELISA, PI, IHC, IF Acetylated lysine-KLH conjugates
Anti-Acetylated Lysine, Biotin Conjugated L95-66BR Rabbit WB, ELISA, IF, IHC, IP Acetylated lysine-KLH conjugates
Anti-Acetylated Lysine, FITC Conjugated L95-66CR Rabbit For direct immunofluorescence assay Acetylated lysine-KLH conjugates
Anti-Acetylated Lysine, HRP Conjugated L95-66DR Rabbit WB, ELISA, IF, IHC, IP Acetylated Lysine-KLH conjugates
Anti-Methylated Arginine (NG, NG-Di-methyl) A96-67R Rabbit WB, ELISA, IF, IHC, IP NG, NG-di-methylated arginine-KLH conjugates
Anti-Methylated Arginine (NG-Mono-methyl) A95-67R Rabbit WB, ELISA, IF, IHC, IP NG-mono-methylated arginine-KLH conjugates
Anti-Methylated Lysine (Tri- epsilon-N-methyl) L95-67R Rabbit WB, ELISA, IF, IHC, IP Methylated lysine-KLH conjugates.
Anti-Methylated Lysine (Tri- epsilon-N-methyl), Biotin Conjugated L95-67BR Rabbit WB, ELISA, IF, IHC Methylated lysine-KLH conjugates.
Anti-Methylated Lysine (Tri- epsilon-N-methyl), FITC Conjugated L95-67CR Rabbit For direct immunofluorescence assay Methylated lysine-KLH conjugates.
Anti-Methylated Lysine (Tri- epsilon-N-methyl), HRP Conjugated L95-67DR Rabbit WB, ELISA, IF, IHC, IP Methylated lysine-KLH conjugates.
Anti-Phosphoserine (Anti-pS) S95-65R Rabbit WB, ELISA, IHC, IP Phosphoserine peptide-KLH conjugates
Anti-Phosphoserine (Anti-pS), Biotin Conjugated S95-65BR Rabbit WB, ELISA Phosphoserine peptide-KLH conjugates
Anti-Phosphothreonine (Anti-pT) T95-65R Rabbit WB, ELISA, IHC, IP Phosphothreonine peptide-KLH conjugates
Anti-Phosphothreonine (Anti-pT), Biotin Conjugated T95-65BR Rabbit WB, ELISA Phosphothreonine peptide-KLH conjugates
Anti-Phosphotyrosine (Anti-pY) T96-65R Rabbit WB, ELISA, IHC, IP Phosphotyrosine peptide-KLH conjugates
Anti-Phosphotyrosine (Anti-pY), Biotin Conjugated T96-65BR Rabbit WB, ELISA, IHC, IP Phosphotyrosine peptide-KLH conjugates
Name Catalogue Number Host Cited Application Immunogen
Anti-5-Methylated Cytosine (5-methyl cytosine) C92-67S Sheep, IgG WB, IP 5-Methylated Cytosine (5-methyl cytosine)
Anti-Acetylated Lysine L95-66R Rabbit WB, ELISA, PI, IHC, IF Acetylated lysine-KLH conjugates
Anti-Acetylated Lysine, Biotin Conjugated L95-66BR Rabbit WB, ELISA, IF, IHC, IP Acetylated lysine-KLH conjugates
Anti-Acetylated Lysine, FITC Conjugated L95-66CR Rabbit For direct immunofluorescence assay Acetylated lysine-KLH conjugates
Anti-Acetylated Lysine, HRP Conjugated L95-66DR Rabbit WB, ELISA, IF, IHC, IP Acetylated Lysine-KLH conjugates
Anti-Methylated Arginine (NG, NG-Di-methyl) A96-67R Rabbit WB, ELISA, IF, IHC, IP NG, NG-di-methylated arginine-KLH conjugates
Anti-Methylated Arginine (NG-Mono-methyl) A95-67R Rabbit WB, ELISA, IF, IHC, IP NG-mono-methylated arginine-KLH conjugates
Anti-Methylated Lysine (Tri- epsilon-N-methyl) L95-67R Rabbit WB, ELISA, IF, IHC, IP Methylated lysine-KLH conjugates.
Anti-Methylated Lysine (Tri- epsilon-N-methyl), Biotin Conjugated L95-67BR Rabbit WB, ELISA, IF, IHC Methylated lysine-KLH conjugates.
Anti-Methylated Lysine (Tri- epsilon-N-methyl), FITC Conjugated L95-67CR Rabbit For direct immunofluorescence assay Methylated lysine-KLH conjugates.
Anti-Methylated Lysine (Tri- epsilon-N-methyl), HRP Conjugated L95-67DR Rabbit WB, ELISA, IF, IHC, IP Methylated lysine-KLH conjugates.
Anti-Phosphoserine (Anti-pS) S95-65R Rabbit WB, ELISA, IHC, IP Phosphoserine peptide-KLH conjugates
Anti-Phosphoserine (Anti-pS), Biotin Conjugated S95-65BR Rabbit WB, ELISA Phosphoserine peptide-KLH conjugates
Anti-Phosphothreonine (Anti-pT) T95-65R Rabbit WB, ELISA, IHC, IP Phosphothreonine peptide-KLH conjugates
Anti-Phosphothreonine (Anti-pT), Biotin Conjugated T95-65BR Rabbit WB, ELISA Phosphothreonine peptide-KLH conjugates
Anti-Phosphotyrosine (Anti-pY) T96-65R Rabbit WB, ELISA, IHC, IP Phosphotyrosine peptide-KLH conjugates
Anti-Phosphotyrosine (Anti-pY), Biotin Conjugated T96-65BR Rabbit WB, ELISA, IHC, IP Phosphotyrosine peptide-KLH conjugates

SignalChem manufactures a broad range of recombinant cell signaling proteins paying thorough attention to quality to assist in global academic research and drug discovery efforts. Our comprehensive family offering of signaling protein products have been utilized by many pharmaceutical companies in their research and drug discovery programs. Explore Signalchem’s cell signaling protein product range to study molecular and cell signaling pathways.

Adaptor Proteins

Name Catalog Number Species Tag Expression System Sequence Genbank Number
FADD Protein F02-30H Human HIS E.coli Full Length NM_003824
GAB1 Protein G03-30H Human HIS Sf9 insect cells using baculovirus Full Length NM_207123
GRB2 Protein G45-30G Human GST E.coli Full Length NM_002086
GRB7 Protein G45-30GG Human GST E.coli Full Length NM_001030002
NCK Protein N06-30H Human HIS Sf9 insect cells using baculovirus Full Length NM_006153
TRAF1 Protein T56-30G Human GST Sf9 insect cells using baculovirus Full Length NM_005658
TRAF2 Protein T57-30G Human GST Sf9 insect cells using baculovirus Full Length NM_021138

Apoptosis Proteins

Name Catalog Number Species Tag Expression System Sequence Genbank Number
ATG13 Protein A113-30G Human GST E.coli Full Length NM_001142673
BAD Protein B03-30G Human GST Sf9 insect cells using baculovirus Full Length NM_032989
BAG1 Protein B05-31G Human GST E.coli 72-end NM_004323
BAX Protein B14-30G Human GST E.coli Full Length NM_004324
BCL2 Protein B25-30G Human GST E.coli Full Length NM_000633
BID Protein B59-30G Human GST Sf9 insect cells using baculovirus Full Length BC036364
XIAP Protein X08-30G Human GST Sf9 insect cells using baculovirus Full Length NM_001167

Cell Cycle Proteins

Name Catalog Number Species Tag Expression System Sequence Genbank Number
CDC7 Protein C26-30G Human GST Sf9 insect cells using baculovirus Full Length NM_003503
CDK2 Protein C29-30G Human GST Sf9 insect cells using baculovirus Full Length NM_001798
CDK5P25 Protein C34-31G Human GST Sf9 insect cells using baculovirus 98-end NM_003885
CDK5P35 Protein C34-30G Human GST Sf9 insect cells using baculovirus Full Length NM_003885
CDKN3 Protein C01-34G Human GST Sf9 insect cells using baculovirus Full Length NM_005192
Cyclin E2 Protein C82-30BG Human GST Sf9 insect cells using baculovirus Full Length NM_057749
Cyclin T2 Protein C86-30BG Human GST Sf9 insect cells using baculovirus Full-Length NM_001241
Cyclin Y Protein C87-30G Human GST Sf9 insect cells using baculovirus 2-end NM_145012
CyclinA2 Protein C78-30BG Human GST Sf9 insect cells using baculovirus Full Length NM_001237
CyclinC Protein C80-30G Human GST Sf9 insect cells using baculovirus Full Length NM_005190
CyclinD1 Protein C81-30G Human GST E.coli Full Length NM_053056
CyclinD1 Protein C81-30BG Human GST Sf9 insect cells using baculovirus Full Length NM_053056
CyclinD3 Protein C81-30B3G Human GST Sf9 insect cells using baculovirus Full length NM_001760
CyclinE1 Protein C82-30G Human GST Sf9 insect cells using baculovirus Full Length NM_001238
CyclinH Protein C83-30H Human HIS Sf9 insect cells using baculovirus Full Length NM_001239
CyclinK Protein C84-30G Human GST Sf9 insect cells using baculovirus Full Length BC015935
CyclinO Protein C85-30G Human GST Sf9 insect cells using baculovirus Full Length NM_021147
MDM2 (1-118) Protein M45-31BH Human HIS E.coli 1-118 NM_002392
MDM2 Protein M45-31G Human GST E.coli 202-end NM_002392
MDM4 (1-137) Protein M47-31BH Human HIS E.coli 1-137 NM_002393
p15INK4B Protein C31-30G Human GST E.coli Full Length NM_004936
p16INK4A Protein C30-30G Human GST E.coli Full Length NM_000077
p18INK4C Protein C32-30G Human GST E.coli Full Length NM_001262
p19INK4D Protein C33-30G Human GST E.coli Full Length NM_001800
p21CIP1 Protein C27-30G Human GST E.coli Full Length NM_000389
p27KIP1 Protein C28-30G Human GST E.coli Full Length NM_004064
p33ING1 Protein I32-30H Human HIS Sf9 insect cells using baculovirus Full Length NM_198219
p33ING2 Protein I32-30BG Human GST Sf9 insect cells using baculovirus Full Length NM_001564
p53 Protein P05-30G Human GST E.coli Full Length NM_000546
p53 Protein P05-30BG Human GST Hi5 insect cells using baculovirus Full Length NM_000546
p63 Protein P06-30G Human GST Sf9 insect cells using baculovirus Full Length NM_001114980
p73 alpha Protein P08-30G Human GST Sf9 insect cells using baculovirus Full Length NM_005427
p73 beta Protein P08-30BG Human GST Sf9 insect cells using baculovirus Full Length O15350-2
p73 gamma Protein P08-30CG Human GST Sf9 insect cells using baculovirus Full Length O15350-3

Cell Stress & Chaperone Proteins

Name Catalog Number Species Tag Expression System Sequence Genbank Number
14-3-3 alpha/beta Protein Y71-30G Human GST E.coli Full Length NM_003404
14-3-3 alpha/beta Protein Y71-30N Human TAG-Free E.coli Full Length NM_003404
14-3-3 alpha/beta Protein Y71-30H Human HIS Sf9 insect cells using baculovirus Full Length NM_003404
14-3-3 alpha/beta Protein Y71-30BH Mouse HIS Sf9 insect cells using baculovirus Full Length NM_018753
14-3-3 epsilon Protein Y75-30G Human GST E.coli Full Length NM_006761
14-3-3 epsilon Protein Y75-30N Human TAG-Free E.coli Full Length NM_006761
14-3-3 epsilon Protein Y75-30H Human HIS Sf9 insect cells using baculovirus YWHAE, MDS, MDCR, KCIP-1, 14-3-3E, FLJ45465 NM_006761
14-3-3 epsilon Protein Y75-30BH Mouse HIS Sf9 insect cells using baculovirus NM_009536
14-3-3 sigma Protein Y86-30G Human GST E.coli Full Length NM_006142
14-3-3 sigma Protein Y86-30N Human TAG-Free E.coli Full Length NM_006142
14-3-3 sigma Protein Y86-30H Human HIS Sf9 insect cells using baculovirus Full Length NM_006142
14-3-3 theta Protein Y84-30G Human GST E.coli Full Length NM_006826
14-3-3 theta Protein Y84-30N Human TAG-Free E.coli Full Length NM_006826
14-3-3 theta Protein Y84-30H Human HIS Sf9 insect cells using baculovirus Full Length NM_006826
14-3-3 theta Protein Y84-30BH Mouse HIS Sf9 insect cells using baculovirus Full Length NM_011739
14-3-3 zeta Protein Y92-30G Human GST E.coli Full Length NM_003406
14-3-3 zeta Protein Y92-30N Human TAG-Free E.coli Full Length NM_003406
14-3-3 zeta Protein Y92-30H Human HIS Sf9 insect cells using baculovirus Full Length NM_003406
14-3-3 zeta Protein Y92-30BH Mouse HIS Sf9 insect cells using baculovirus Full Length NM_011740
CRYAA Protein C256-30H Human HIS E.coli Full Length NM_000394
GST Protein G52-30U Artificial TAG-Free E.coli 1-226 U13850
HO1 Protein H20-30G Human GST E.coli Full Length NM_002133
HO2 Protein H21-30G Human GST E.coli Full Length NM_002134
HSP10 Protein H29-54G Human GST E.coli Full Length NM_002157
HSP27 Protein H30-54G Human GST E.coli Full Length NM_001540
HSP40 Protein H32-54G Human GST E.coli Full Length NM_006145
HSP60 Protein H33-54G Human GST E.coli Full Length NM_002156
HSP70 Protein H34-54G Human GST E.coli Full Length NM_005345
HSP70 Protein H34-54H Human HIS Sf9 insect cells using baculovirus Full Length NM_005345
HSP90 alpha Protein H36-50H Human HIS Sf9 insect cells using baculovirus Full Length NM_005348
HSP90 beta Protein H36-54H Human HIS Sf9 insect cells using baculovirus Full Length NM_ 007355
Mortalin Protein M54-31G Human GST Sf9 insect cells using baculovirus 47-end NM_004134
PARK7 (DJ-1) Protein P219-31H Human HIS E.coli 19-end NM_007262

Color Proteins

Name Catalog Number Species Tag Expression System Sequence Genbank Number
BFP Protein B620-30H HIS E.coli 228-end DQ399412
eRFP Protein R620-30BH HIS E.coli Full Length AY130757
Red Protein R620-30CH HIS E.coli Full Length EU498726
RFP Protein R620-30H HIS E.coli Full Length AAF03369
Y1BFP Protein B620-30BH HIS E.coli Full Length BAG71497

Microtubule & Actin Associated Proteins

Name Catalog Number Species Tag Expression System Sequence Genbank Number
Alpha-synuclein Protein S22-30H Human HIS E.coli Full Length NM_000345
Beta-synuclein Protein S22-30BH Human E.coli Full Length NM_003085
Cofilin 1 Protein C37-54H Human HIS E.coli Full Length NM_005507
Gamma-synuclein Protein S22-30CH Human HIS E.coli Full Length NM_003087
INCENP Protein I30-31H Human HIS Sf9 insect cells using baculovirus 783-end NM_001040694
Stathmin Protein S71-30H Human HIS E.coli Full Length BC014353
TPM3 Protein T36-30H Human HIS E.coli Full Length NM_152263
TPX2 Protein T40-30H Human HIS Sf9 insect cells using baculovirus Full Length NM_012112
Troponin1 Protein T68-30H Human HIS E.coli Full Length NM_003281
Tubulin Beta (TUBB1) Protein T92-50G Human GST E.coli Full Length NM_178014
Vimentin Protein V49-30H Human HIS E.coli Full Length NM_003380

Regulatory Proteins

Transcription Proteins

Name Catalog Number Species Tag Expression System Sequence Genbank Number
ATF1 Protein A09-54G Human GST Sf9 insect cells using baculovirus Full Length NM_005171
c-JUN Protein J05-55G Human GST E.coli Jan-79 NM_002228
Catenin alpha Protein C05-30G Human GST Sf9 insect cells using baculovirus Full Length NM_001903
Catenin beta Protein C06-30G Human GST Sf9 insect cells using baculovirus Full Length NM_001904
CBP Protein C07-31G Human GST E.coli 1319-1710 NM_004380
CREB1 Protein C49-55G Rat GST E.coli 1-280 NM_031017
ELK1 Protein E64-30G Human GST E.coli Full Length NM_005229
FOS Protein F66-30G Human GST Sf9 insect cells using baculovirus Full Length NM_005252
FOXL2 Protein F71-30BG Human GST Sf9 insect cells using baculovirus Full Length NM_023067
HIF1B Protein H07-30BG Human GST Sf9 insect cells using baculovirus Full Length NM_001668
HSF1 Protein H25-30G Human GST E.coli Full Length NM_005526
IkBA Protein I20-30G Human GST E.coli Full Length NM_020529
IkBA Protein I20-31G Human GST E.coli 1-175 NM_020529
IkBB Protein I21-30G Human GST E.coli Full Length NM_002503
NFATC1 Protein N12-30G Human GST Sf9 insect cells using baculovirus Full Length NM_172390
NFKB2 Protein N13-31G Human GST Sf9 insect cells using baculovirus 1-454 NM_002502
Rel B Protein R30-30H Human HIS Sf9 insect cells using baculovirus Full Length NM_006509
SMAD1 Protein S10-30G Human GST E.coli Full Length NM_005900
SMAD2 (del SXS) Protein S11-31G Human GST E.coli C-terminal SXS deletion NM_001003652
SMAD2 Protein S11-30G Human GST E.coli Full Length NM_001003652
SMAD3 (del SXS) Protein S12-31G Human GST E.coli C-terminal SXS deletion NM_005902
SMAD3 Protein S12-30G Human GST E.coli Full Length NM_005902
SMAD4 Protein S13-30G Human GST E.coli Full Length NM_005359
SMAD5 Protein S14-30G Human GST E.coli Full Length NM_005903
SMAD9 Protein S17-30G Human GST E.coli Full Length NM_001127217
STAT1 alpha Protein S52-50G Human GST Sf9 insect cells using baculovirus Full Length NM_139266
STAT1 beta Protein S52-54G Human GST Sf9 insect cells using baculovirus Full Length NM_139266
STAT2 Protein S53-54G Human GST Sf9 insect cells using baculovirus Full Length NM_005419
STAT3 Protein S54-54G Human GST Sf9 insect cells using baculovirus Full Length NM_139276
STAT3 Protein S54-54BH Human HIS Sf9 insect cells using baculovirus Full Length NM_139276
STAT4 Protein S55-54H Human HIS Sf9 insect cells using baculovirus Full Length NM_003151
STAT5 Protein S56-54H Human HIS Sf9 insect cells using baculovirus Full Length NM_003152
STAT5B Protein S56-54BG Human GST Sf9 insect cells using baculovirus Full Length BC065227
STAT5B Protein S56-54BH Human HIS Sf9 insect cells using baculovirus Full Length BC065227
STAT6 Protein S57-30G Human GST Sf9 insect cells using baculovirus Full Length BC075852
TDP43 Protein T74-30G Human GST E.coli Full Length NM_007375

SignalChem offers a wide range of recombinant cytokines, chemokines and growth factors manufactured under strict quality controls. With high purity and endotoxin levels of ≤ 0.1 ng/ug (IEU/ug), our ligands are perfect candidates to be included in your research and drug discovery projects.

Growth Factors

Chemokines

Name Catalog Number Species Tag Expression System Sequence Genbank Number
IP-10 I838-40N Human HIS E.coli 22-98 NP_001556.2
RANTES (CCL5) R801-40N Human E.coli AAH08600
SDF-1 S821-40N E.coli MKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALN

Cytokines

Name Catalog Number Species Tag Expression System Sequence Genbank Number
IFN-gamma I837-40N Human E.coli NP_000610.2
TNF-alpha T860-40N Human E.coli P01375
TNF-beta T861-40BG Mouse GST Sf9 insect cells using baculovirus 34-end P09225
TNFB T861-40N Human E.coli 35-205 AAH34729.1
TRAIL T880-40N Human E.coli 114-281 NP_003801.1
VEGF-C V812-40N Human E.coli NP_005420.1

Tau proteins constitute a family of very important neuronal proteins that bind to the neuronal microtubules. As one of the first discovered and characterized microtubule-associated proteins, the role of Tau proteins has ever since been associated with an array of neuro-biochemical processes including formation and maintenance of neuronal transport system. Researchers have been constantly monitoring the role of myriad Tau proteins in neuronal pathways and their mutagenesis in neurodegenerative disorders such as Alzheimer’s disease.

Abnormal phosphorylation of Tau can lead to deposits of Tau filaments leading to severe pathogenesis in multiple neurodegenerative disorders such as Alzheimer’s disease. Over the years there has been an exponential boost in Tau research after multiple neurodegenerative diseases displayed tangled forms of Tau proteins in the brain. These observations have established Tau proteins as key potential therapeutic targets for neurodegenerative diseases and motivated scientists globally to invest their drug discovery efforts in understanding the Tau proteins and in developing novel therapeutics to modulate their functions.

Signalchem manufactures one of the most comprehensive selections of recombinant Tau proteins in the world. These include various protein isoforms, phospho-Taus, and mutant variants. Our selection of a wide range of Tau proteins demonstrates SignalChem’s drive to provide quality reagents to facilitate research in neurobiology and these proteins have so far been utilized in a variety of fields including neurodegeneration, oncology, epigenetics, cell stress, and more.

 

Name Catalog Number Species Tag Expression System Sequence Genbank Number
Tau Protein Marker T08-07N
Tau-316 Protein T02-54N Human TAG-Free E.coli Full Length P10636-3
Tau-352 Protein T03-54N Human TAG-Free E.coli Full Length P10636-2
Tau-381 Protein T04-54N Human TAG-Free E.coli Full Length P10636-4
Tau-383 (N352H) Protein T05-56N Human TAG-Free E.coli Full Length (N352H) P10636-6
Tau-383 Protein T05-54N Human TAG-Free E.coli Full Length P10636-6
Tau-410 Protein T06-54N Human TAG-Free E.coli Full Length P10636-5
Tau-412 Protein T07-54N Human TAG-Free E.coli Full Length P10636-7
Tau-412, GSK3beta-phosphorylated T07-50CN Human E.coli Full length P10636-7
Tau-441 (1-391) Protein T08-55CN Human TAG-Free E.coli 1-391 P10636-8
Tau-441 (1-421) Protein T08-55BN Human TAG-Free E.coli 1-421 P10636-8
Tau-441 (127-421) Protein T08-55KN Human E.coli 127-421 P10636-8
Tau-441 (151-391) Protein T08-55FN Human TAG-Free E.coli 151-391 P10636-8
Tau-441 (151-421) Protein T08-55EN Human TAG-Free E.coli 151-421 P10636-8
Tau-441 (151-441) Protein T08-55DN Human TAG-Free E.coli 151-441 P10636-8
Tau-441 (216-391) Protein T08-55LN Human TAG-Free E.coli 216-391 P10636-8
Tau-441 (231-391) Protein T08-55IN Human TAG-Free E.coli 231-391 P10636-8
Tau-441 (231-421) Protein T08-55HN Human TAG-Free E.coli 231-421 P10636-8
Tau-441 (231-441) Protein T08-55GN Human TAG-Free E.coli 231-441 P10636-8
Tau-441 (244-372) Protein T08-55N Human TAG-Free E.coli 244-372 P10636-8

Compounds such as enzyme activity modulators (activators and inhibitors) are important tools to study an enzyme’s role in key cell signaling pathways and enzymatic reactions. SignalChem offers one of the most comprehensive ranges of biologically active recombinant enzymes as well as a broad range of high- quality/low-cost enzyme activators and inhibitors of different classes of enzymes including protein kinases, phosphatases, and epigenetic enzymes. These compounds would enable scientists to study cell signaling pathways and facilitate enzyme research and drug discovery projects.

Name Catalog Number CAS Registration Number Molecular Formula Purity Chemical Name
6BIO G08-900 667463-62-9 C16H10BrN3O2 98% (TLC: 5% CH3OH3 in CH2Cl2, Rf=0.43); NMR (Conforms) (2’Z,3’E)-6-Bromoindirubin -3′-oxime
7-CL-O-Nec-1 R07-901B 852391-15-2 C13H12ClN3O >98% (TLC); NMR (Conforms) Nec-1s; 5-((7-Chloro-1H-indol -3-yl)methyl)-3-methylimidazolidine-2,4-dione
A83-01 A09-900 909910-43-6 C25H19N5S >98% (TLC); NMR (Conforms) 3-(6-Methyl-2-pyridinyl)-N-phenyl -4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
AAL-993 F11-900C 269390-77-4 C20H16F3N3O >98% (TLC); NMR (Conforms) 2-((4-Pyridyl)methyl)amino-N-(3 (trifluoromethyl)phenyl)benzamide
AG-1296 P12-900 146535-11-7 C16H14N2O2 >98% (TLC); NMR (Conforms) 6,7-Dimethoxy-3-phenyl quinoxaline
AG-1478 E10-900B 175178-82-2 C16H14ClN3O2 >98% (TLC); NMR (Conforms) 1. N-(3-Chlorophenyl)-6,7- dimethoxy-4-quinazolinanine
AG-1517 K11-900B 153436-54-5 C16H14BrN3O2 ∙ HCl >98% (TLC); NMR (Conforms) 1. 4-(3-Bromoanilino)-6,7- dimethoxyquinazoline hydrochloride
AG-490 J02-901 133550-30-8 C17H14N2O3 >98% (TLC); NMR (Conforms) (E)-2-Cyano-3-(3,4-dihydrophenyl) -N-(phenylmethyl)-2-propenamide
AG-879 N28-909B 148741-30-4 C18H24N2OS >99% (TLC); NMR (Conforms) alpha-Cyano-(3,5-di-t-butyl-4-hydroxy) thiocinnamide
Alsterpaullone G09-901C 237430-03-4 C16H11N3O3 >96% (TLC); NMR (Conforms) 9-Nitro-7,12-dihydroindolo-[3,2-d] [1] benzazepin-6(5)-one
Amlexanox T02-901 68302-57-8 C16H14N2O4 >98% (TLC); NMR (Conforms) 2-Amino-7-(1-methylethyl)-5-oxo-5H- [1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Apigenin K10-900C 520-36-5 C15H10O5 >98% (TLC); NMR (Conforms) 4’,5,7-Trihydroxyflavone
AR-A014418 G09-901 487021-52-3 C12H12N4O4S >98% (TLC); NMR (Conforms) N-[(4-Methoxyphenyl) methyl]-N’-(5-nitro-2-thiazolyl) urea
AS-041164 P29-901 6318-41-8 C11H7NO4S >98% (TLC); NMR (Conforms) 1. 5-Benzo[1,3]dioxol-5- ylmethylene-thiazolidine-2,4-dione
BAY 11-7082 C51-900 19542-67-7 C10H9NO2S >98% (TLC); NMR (Conforms) (E)-3-[(4-methylphenylsulfonyl] -2-propenenitrile
BML-259 C33-901 267654-00-2 C14H16N2OS >98% (TLC: 5% CH3OH/CH2Cl2; Rf=0.46); NMR (Conforms) N-(5-Isopropylthiazol-2-yl) phenylacetamide
BML-277 C48-901 516480-79-8 C20H14ClN3O2 ≥98% (TLC; 1:1 ethylacetate: hexane; Rf=0.17); NMR (Conforms) 1. 2-(4-(4-chlorophenoxy)phenyl)- 1H-benzimidazole-5-carboxamide
BRD-7389 R15-901 376382-11-5 C24H18N2O2 >98% (TLC); NMR (Conforms) 1-[(2-Phenylethyl)amino]-3H-naphtho [1,2,3-de]quinoline-2,7-dione
CHIR-99021 G09-901B 252917-06-9 C22H18Cl2N8 >98% (TLC); NMR (Conforms) 6-[[2-[[4-(2,4-Dichlorophenyl)-5- (5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl] amino] ethyl] amino]-3-pyridinecarbonitrile
CID-2011756 P72-901 638156-11-3 C22H21ClN2O3 ≥98% (TLC); NMR (Conforms) 5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl) phenyl]-2-furancarboxamide
Name Catalog Number CAS Registration Number Molecular Formula Purity Chemical Name
Cantharidin P16-902C 56-25-7 C10H12O4 >98% (HPLC) 3α,7α-Dimethylhexahydro-4,7- epoxyisobenzofuran-1,3-dione
NSC-663284 C04-902 383907-43-5 C15H16ClN3O3 >98% 6-Chloro-7-[[2-(4-morpholinyl) ethyl]amino]-5,8-quinolinedione
Okadaic acid, free acid P16-902 78111-17-8 C44H68O13 >98% (TLC) None
Name Catalog Number CAS Registration Number Molecular Formula Purity Chemical Name
2’-Deoxy-5-fluorocytidine D353-904D 10356-76-0 C9H12FN3O4 >98% 5-Fluoro-2’-deoxycytidine; FCDR; FdCyd; NSC-48006
5-Azacytidine D353-904 320-67-2 C8H12N4O5 >98% (TLC) 4-Amino-1-(beta-D-ribofuranosyl)- 1,3,5-triazin-2(1H)-one, Ladakamycin
AK-7 S36-904 420831-40-9 C19H21BrN2O3S 98% (TLC) N-(3-Bromophenyl)-3-[(hexahydro-1H -azepin-1-yl)sulfonyl]benzamide
APICIDIN H83-904B 183506-66-3 C34H49N5O6 ≥98% Cyclo[(2S)-2-Amino-8-oxodecanoyl-1- methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
BIX-01294 3HCl S344-903 935693-62-2 C28H38N6O2.3HCl >98% 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl) -6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl] -4-quinazolinamine trihydrochloride
BML-210 H83-904C 537034-17-6 C20H25N3O2 98% N1-(2-aminophenyl)-N8-phenyloctanediamide
C-646 K311-903 328968-36-1 C24H19N3O6 >98% 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl] methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
Chaetocin K421-904C 28097-03-2 C30H28N6O6S4 >99% Lys methyltransferase inhibitor
CPTH2 K311-903B 357649-93-5 C14H14ClN3S >98% (TLC) Cyclopentylidene-[4-(4’-chlorophenyl)thiazol-2-yl]hydrazone
CUDC-101 H83-904 1012054-59-9 C24H26N4O4 >99% (HPLC) 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin -6-yl)oxy)-N-hydroxyheptanamide
Daminozide K421-904B 1596-84-5 C6H12N2O3 98% 1-(2,2-Dimethylhydrazide)butanedioic acid
Decitabine D353-904B 2353-33-5 C8H12N4O4 >98% 5-Aza-2’-deoxycytidine; NSC-127716
DMOG J48-904 89464-63-1 C6H9NO5 >98% N-(2-Methoxy-2-oxoacetyl)glycine methyl ester; Dimethyloxalylglycine
EX-527 S35-904F 49843-98-3 C13H13ClN2O 98% (TLC) 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (racemic)
Garcinol K311-903C 78824-30-3 C38H50O6 >97% (TLC) Camboginol, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl- 1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2- (1-methylethenyl)-4-hexen-1-yl]- bicyclo[3.3.1]non-3-ene-2,9-dione
GSK-J1 (Free acid) J48-904B 1373422-53-7 C22H23N5O2 99% N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3- benzazepin-3-yl)-4-pyrimidinyl]-β-alanine
GSK-J4 (ethylester) J48-904C 1373423-53-0 C24H27N5O2 >99% N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3- benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
HPA (HEXYL-4-PENTYNOIC ACID) H83-904D 96017-59-3 C11H18O2 >97% (TLC) 2-(2-propynyl)octanoic acid (racemic); HPA
IOX1 (8H5QCA) J48-904D 5852-78-8 C10H7NO3 >98% (HPLC) 5-Carboxy-8-hydroxyquinoline, 8-Hydroxy-5-quinolinecarboxylic acid
ML-324 J48-904E 1222800-79-4 C21H23N3O2 >98% (TLC) N-(3-(dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide
Name Catalog Number CAS Registration Number Molecular Formula Purity Chemical Name
BML-278 S35-904C N/F C24H25NO4 >98% (TLC) N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
CTPB P07-903 586976-24-1 C31H43ClF3NO2 98% N-(4-chloro-3-trifluoromethyl-phenyl) -2-ethoxy-6-pentadecyl-benzamide
Resveratrol S35-904 501-36-0 C14H12O3 >98% 3,4’,5-Trihydroxy-trans-stilbene; 5-[(1E)-2- (4-Hydroxyphenyl)ethenyl]-1,3,benzenediol
SirtAct S35-904E 839699-72-8 C20H25N5O2 98% (TLC) 2-Amino-N-cyclopentyl-1-(3-methoxypropyl) -1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide; CAY10591
Name Catalog Number CAS Registration Number Molecular Formula Purity Chemical Name
8-pCPT-2-O-Me-cAMP-AM R46-905 1152197-23-3 C20H21ClN5O8PS >97% (HPLC) 8-(4-Chlorophenylthio)-2′-O-methyladenosine-3’, 5′-cyclic monophosphate acetoxymethyl ester
AICAR P47-900B 2627-69-2 C9H14N4O5 >99% (TLC); NMR (Conforms) 1. 5-Aminoimidazole-4-carboxamide 1-B-D-ribofuranoside 2. Acadesine
MHY-1485 F17-901B 326914-06-1 C17H21N7O4 >98% (TLC); NMR (conforms) 4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
SC-79 A16-901 305834-79-1 C17H17ClN2O5 98% (TLC); NMR (Conforms) 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl) -4H-1-benzopyran-4-acetic acid, ethyl ester

Bioreagents are crucial components in regular laboratory applications like enzyme assays. Without high-quality reagents, it is impossible to generate desired assay results, hampering important disease research and drug discovery projects. Our scientific team has over 100 years of combined research and industrial experience in the recombinant proteins and bioreagent production.

SignalChem’s expertise allows us to understand the importance of the quality of assay reagents and substrates in research and our goal is to provide highest-quality bioreagents to the global scientific community. We offer high quality and cost-effective bioreagents such as assay reagents, peptide substrates, oligo substrates, lipid substrates, and more.

 

Name Catalog Number Application
Acetyltransferase Assay Buffer A01-09 Acetyltransferase Assay
Acetyltransferase Dilution Buffer A21-09 Acetyltransferase Assay
AMP Solution A46-09 Kinase Assay
ATP Stock Solution A50-09 Kinase Assay
Ca2+/Calmodulin Solution II, 10x C02-39B Kinase Assay
CaCl2 Solution C02-09 Enzyme Assay
cAMP Solution A47-09 Enzyme Assay
cGMP Solution G47-09 Enzyme Assay
DTT Solution D86-09B
DTT Solution D86-09
DUB Reaction Buffer (4X) D01-09
Fructose Kinase Assay Buffer I F01-09 Enzyme Assay
Fructose Kinase Dilution Buffer I F21-09 Enzyme Assay
GTP Solution G50-09 Enzyme Assay
GTP Solution II G50-09B Enzyme Assay
Kinase Assay Buffer I K01-09 Kinase Assay
Kinase Assay Buffer II K02-09 Kinase Assay
Kinase Assay Buffer III K03-09
Kinase Dilution Buffer I K21-09 Kinase Assay
Kinase Dilution Buffer II K22-09 Kinase Assay

Bioreagents are crucial components in regular laboratory applications like enzyme assays. It is essential to use high-quality bioreagents to develop reliable assay methods and to generate reproducible and good-quality assay results. Our scientific team has over 100 years of combined research and industrial experience in the production of recombinant proteins and bioreagents. We leverage our expertise and experience to provide the global scientific community with the high quality and cost-effective bioreagents such as assay reagents, peptide substrates, oligo substrates, lipid substrates, siRNA reagents and more.

Name Catalog Number
DLG (Dilauroyl-sn-glycerol) D430-59
PI (Phosphatidylinositol) P420-59
PI(3)P P421-59
PI(3)P:PS P426-59
PI(4)P P422-59
PI(4)P:PS P427-59
PI(4,5)P2 P424-59
PI(4,5)P2:PS P429-59
PI(5)P P423-59
PI(5)P:PS P428-59
PI:PS P425-59B
Name Catalog Number Application
DNMT Substrate-1 D53-58 DNA methyltransferase assay (50pmole per reaction).
METTL3/METTL14 Substrate M323-58 A methyltransferase METTL3/METTL14 complex assay.
Poly (1:1 dI, dC) Acid P62-58 DNA methyltransferase assay (0.25ug per reaction).
Name Catalog Number Application
Abltide A02-58 Kinase Assay
Acetylated Histone H3 Peptide I H12-358 Acetylation/Methylation Assays
Acetylated Histone H4 Peptide I H13-358 Acetylation/Methylation Assays
AKT (PKB) Substrate A05-58 Kinase Assay
AKT (SGK) Substrate A08-58 Kinase Assay
AMARA Peptide A11-58 Kinase Assay
Amyloid beta (1-11) Peptide A06-558B
Amyloid beta (1-15) Peptide A06-558I
Amyloid beta (11-20) Peptide A06-558K
Amyloid beta (11-40) Peptide A06-558G
Amyloid beta (11-40), pyrE A06-558H
Amyloid beta (11-42) Peptide A06-558W
Amyloid beta (11-42), pyrE A06-558X
Amyloid beta (12-28) Peptide A06-558L
Amyloid beta (17-28) Peptide A06-558M
Amyloid beta (25-35), C-terminal-amide A06-558O
Amyloid beta (25-35), C-terminal-OH A06-558N
Amyloid beta (25-35), N-Alpha-Biot-LC Labeled A06-558Q
Amyloid beta (25-35), Scrambled A06-558P
Amyloid beta (29-40) Peptide A06-558R
Name Catalog Number Application
ARPP19 Protein A76-54G Western Blot
Casein Protein C03-54N Kinase Assay, Western Blot
Casein, Dephosphorylated C03-54BN Kinase Assay, Western Blot
DUB Substrate I U06-57
DUB Substrate II S293-57
DUB Substrate III N263-57
Histone H1 Protein H10-54N Kinase Assay, Western Blot
Histone H3 Protein H12-54N Kinase Assay, Western Blot
LC20 Protein M89-54G Kinase Assay, Western Blot
MBP Protein M42-51N Kinase Assay, Western Blot
Moesin Protein M52-55G Kinase Assay, Western Blot
PDHA1 Protein P57-55H Kinase Assay, Western Blot
RanGAP1 Protein R298-31H Western Blot
Name Catalog Number Application
D-Fructose-6-phosphate F520-59 PFKFB Assay
D-Glucose-6-phosphate F521-59 PFKFB Assay

Bioreagents are crucial components in regular laboratory applications like enzyme assays. It is essential to use high-quality bioreagents to develop reliable assay methods and to generate reproducible and good-quality assay results. Our scientific team has over 100 years of combined research and industrial experience in the production of recombinant proteins and bioreagents. We leverage our expertise and experience to provide the global scientific community with the high quality and cost-effective bioreagents such as assay reagents, peptide substrates, oligo substrates, lipid substrates, siRNA reagents and more.

Name Catalog Number Formulation GenBank ID Specificity
14-3-3 alpha/beta siRNA Set I Y71-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_003404 14-3-3 alpha/beta siRNAs are designed to specifically knock-down human 14-3-3 alpha/beta expression.
14-3-3 epsilon siRNA Set I Y75-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_006761 14-3-3 epsilon siRNAs are designed to specifically knock-down human 14-3-3 epsilon expression.
14-3-3 sigma siRNA Set I Y86-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_006142 14-3-3 sigma siRNAs are designed to specifically knock-down human 14-3-3 sigma expression.
14-3-3 theta siRNA Set I Y84-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_006826 14-3-3 theta siRNAs are designed to specifically knock-down human 14-3-3 theta expression.
14-3-3 zeta siRNA Set I Y92-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_003406 14-3-3 zeta siRNAs are designed to specifically knock-down human 14-3-3 zeta expression.
4EBP1 siRNA Set I E35-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_004095 4EBP1 siRNAs are designed to specifically knock-down human 4EBP1 expression.
AATK siRNA Set I A02-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_007377 AATK siRNAs are designed to specifically knock-down human AATK expression.
ABL1 siRNA Set I A03-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_009594 ABL1 siRNAs are designed to specifically knock-down human ABL1 expression.
ABL2 siRNA Set I A04-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_005158 ABL2 siRNAs are designed to specifically knock-down human ABL2 expression.
ACK siRNA Set I A05-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_005781 ACK siRNAs are designed to specifically knock-down human ACK expression.
ACVR2A siRNA Set I A35-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_001616 ACVR2A siRNAs are designed to specifically knock-down human ACVR2A expression.
ACVR2B siRNA Set I A36-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_001106 ACVR2B siRNAs are designed to specifically knock-down human ACVR2B expression.
ADD1 siRNA Set I A38-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_001119 ADD1 siRNAs are designed to specifically knock-down human ADD1 expression.
AFX siRNA Set I A42-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_001170931 AFX siRNAs are designed to specifically knock-down human AFX expression.
AKT1/PKB alpha siRNA Set I A16-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_005163 AKT1/PKB alpha siRNAs are designed to specifically knock-down human AKT1/PKB alpha expression.
AKT2/PKB beta siRNA Set I A17-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_001626 AKT2/PKB beta siRNAs are designed to specifically knock-down human AKT2/PKB beta expression.
AKT3 siRNA Set I A18-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_005465 AKT3 siRNAs are designed to specifically knock-down human AKT3 expression.
ALK1 siRNA Set I A09-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_000020 ALK1 siRNAs are designed to specifically knock-down human ALK1 expression.
ALK2 siRNA Set I A06-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_001105 ALK2 siRNAs are designed to specifically knock-down human ALK2 expression.
ALK3 (BMPR1A) siRNA Set I B04-911 The siRNAs are supplied as a lyophilized powder and shipped at room temperature. NM_004329 ALK3 (BMPR1A) siRNAs are designed to specifically knock-down human ALK3 (BMPR1A) expression.
Name Catalog Number Formulation Purity Sequence Specificity
beta-Actin Positive Control siRNA A03-911D The siRNAs are supplied as a lyophilized powder and shipped at room temperature. Single PAGE band 5’-UGA AGA UCA AGA UCA UUG CdTdT-3’ and 5’-GCA AUG AUC UUG AUC UUC AdTdT-3’ beta-Actin Positive Control siRNA is designed to specifically knock-down human beta-Actin expression.
Cy3 Labeled Negative Control siRNA S02-910N The siRNAs are supplied as a lyophilized powder and shipped at room temperature. Cy3 Negative Control siRNA duplex resolves as a single band via PAGE 5’-UUC UCC GAA CGU GUC ACG UTT-Cy3-3’ and 5’- ACG UGA CAC GUU CGG AGA ATT-3’
FAM Labeled Negative Control siRNA S03-910N The siRNAs are supplied as a lyophilized powder and shipped at room temperature. ≥ 90% by HPLC 5’-UUC UCC GAA CGU GUC ACG UTT-FAM-3’ and 5’- ACG UGA CAC GUU CGG AGA ATT-3’
GAPDH Positive Control siRNA G13-911B The siRNAs are supplied as a lyophilized powder and shipped at room temperature. Single PAGE band 5’-GUG GAG AUU GUU GCC AUC AdTdT-3’ and 5’- UGA UGG CAA CAA UCU CCA CdTdT-3’ GAPDH Positive Control siRNA is designed to specifically knock-down human GAPDH expression.
Unlabeled Negative Control siRNA S01-910N The siRNAs are supplied as a lyophilized powder and shipped at room temperature. ≥ 90% by HPLC 5’-UUC UCC GAA CGU GUC ACG UTT-3’ and 5’-ACG UGA CAC GUU CGG AGA ATT-3’

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