Quanta BioDesign is a research and manufacturing company committed to the development of a full range of discrete polyethylene glycol (dPEG®) PEGylation reagents for applications in diagnostics, therapeutics, peptide synthesis, oligonucleotide synthesis, and nanotechnology.

Quanta BioDesign’s vision incorporates a dedicated commitment to producing the most useful compounds for your current and future applications and needs using synthetic and process technology that allows the most economic incorporation of these products into your application.


Product Categories

What is dPEG®?

The term “dPEG®” is Quanta BioDesign’s trademarked acronym for “discrete polyethylene glycol” or “discrete PEG”. The “discrete” portion of the dPEG® trademark indicates single molecular weight PEG technology. Like traditional PEGs, our products contain an amphiphilic[1] backbone of repeating ethylene oxide units. However, traditional PEGs are not single compounds. Quanta BioDesign invented and manufactures these monodisperse PEG products using our proprietary synthetic and purification processes.

What is PEGylation?

PEGylation is the process adding polyethylene glycol (PEG) to a molecule or surface, often through covalent modification of the targeted molecule or surface. Molecules and surfaces that have been modified by PEGylation are called PEGylated. Any surface containing appropriate functional groups can be PEGylated. Gold, silver, iron, and silica are examples of surfaces that are often PEGylated for use in diagnostic, therapeutic, or theranostic applications. The list of molecules that are PEGylated is enormously long and continually expanding. Examples of the types of molecules that are PEGylated include small molecule therapeutic drugs, peptides, proteins, the carbohydrate coats of glycoproteins, oligonucleotides, and lipids.

The benefits of PEGylation include increased water solubility, increased hydrodynamic volume, decreased immunogenicity, and extended circulation in vivo in the bloodstream due to reduced renal clearance. In addition to reducing renal clearance, PEGylation also often modifies the biodistribution and pharmacokinetics of therapeutic, theranostic, and diagnostic molecules.

Traditional PEGs

Specifically, traditional PEG products are prepared by polymerization processes. Any polymerized PEG product is a Poisson distribution of chain lengths and molecular weights.[2],[3] This distribution was formerly known as the polydispersity index (PDI), but is now known as the dispersity index or simply dispersity (indicated by the symbol “Đ”)[4]. The reported molecular weight is an average molecular weight, and Đ (or PDI) gives an indication of the range of molecular weights in the sample. Disperse samples have Đ > 1 and are a heterogeneous mixture of sizes and molecular weights. High M.W. (>50 kDa) traditional PEG has Đ up to 1.1. Lower M.W. traditional PEG has Đ in the range of 1.01 – 1.05. These numbers represent broad distributions of molecular weights.[5],[6],[7]

dPEG® Products Are Different

Our dPEG® products are quite different from traditional PEGs, because of our proprietary, patent-protected processes. Each dPEG® product represents a single compound with a unique, specific, single molecular weight (MW). See Figure 1.

Figure 1

Figure 1: Side-by-side comparison of actual mass spectra from a traditional, dispersed PEG (left spectrum) and a dPEG® of equivalent mass from Quanta BioDesign (right spectrum). The mass spectrum on the left is of PEG1000. It has Mw = 1027 Daltons; Mn = 888 Daltons; and Đ = 1.16. The masses in this dispersed PEG range from 600 – 1,500 Daltons. The mass spectrum on the right is of Quanta BioDesign product number 10317, amino-dPEG®24-acid, the structure of which is shown across the top of the two mass spectra. PN10317 is a single molecular weight compound with a single, discrete chain length. The molecular weight of PN10317 is 1146.355 Daltons. Because it has no dispersity, Đ = 1.

A Wide Variety of Functional Groups and Architectures for dPEG® Products

Our dPEG® products are synthesized from high purity building blocks (e.g. diethylene glycol, triethylene glycol, or tetraethylene glycol) in a series of stepwise reactions to provide specific MWs, organic moieties, functional groups (see Figure 2), and architectures (see Figure 3) suited for a wide variety of applications. From these building blocks, we produce homobifunctional and heterobifunctional crosslinkers, homotetrafunctional and homohexafunctional crosslinkers, biotinylation reagents, fluorescent tags, surface modification reagents, and specialized products designed for modification of pharmacokinetics (PK) and biodistribution (BD). Our products contain methoxy, alcohol, and carboxylic acid end-capping; various protective groups for reactive moieties (e.g., methoxytrityl, Fmoc, boc, etc.); various functional groups for conjugation to amines, thiols, alcohols, carboxylic acids, ketones, aldehydes, alkynes, and azides; and a wide variety of organic moieties (i.e., biotin, lipoamide, fluorescein, DOTA, etc.).

Figure 2: Examples of the functional, reactive, labeling, and protective groups on dPEG® products.

Figure 3: Available architectures for dPEG® products. Branched dPEG® products can have three (3) or nine (9) branches. Our Sidewinder™ products are a new class of dPEG® constructs that offer a broad range of new ways to incorporate dPEG® functionality into diagnostic and therapeutic applications.

All dPEG® products contain linear chains of two to seventy-two ethylene oxide units. We also build branched structures consisting of three to nine of these linear chains. Our proprietary synthetic processes maintain homogeneity of our products in the range of 200 Da to 16 kDa. Our Sidewinder™ line of products was designed by Quanta BioDesign’s scientists to provide new ways to incorporate the beneficial properties and advantages of dPEG® products into diagnostic and therapeutic applications. One clear application for these products is fine-tuning PK and BD of diagnostic and therapeutic products. These novel dPEG® products are not possible with traditional disperse PEG products.

References

[1] The term “amphiphilic” means that the compound is soluble in both water (or aqueous buffer) and organic solvents. All PEG products that do not contain hydrophobic substituents are soluble in water and in a variety of organic solvents. The addition of hydrophobic groups to PEG reduces the water solubility of some PEG products.

[2] Flory, P. J. Molecular Size Distribution in Ethylene Oxide Polymers. J. Am. Chem. Soc. 1940, 62, 1561−1565. https://doi.org/10.1021/ja01863a066.

[3] Herzberger, J.; Niederer, K.; Pohlit, H.; Seiwert, J.; Worm, M.; Wurm, F. R.; Frey, H. Polymerization of Ethylene Oxide, Propylene Oxide, and Other Alkylene Oxides: Synthesis, Novel Polymer Architectures, and Bioconjugation. Chem. Rev. 2016, 116, 2170-2243. https://doi.org/10.1021/acs.chemrev.5b00441.

[4] Gilbert, R. G.; Hess, M.; Jenkins, A. D.; Jones, R. G.; Kratochvíl, P.; Stepto, R. F. T. Dispersity in polymer science (IUPAC Recommendations 2009). Pure Appl. Chem. 2009, 81, 351–353. https://doi.org/10.1351/PAC-REC-08-05-02. See also, Stepto, R. F. T. Erratum. Pure Appl. Chem. 2009, 81, 779. https://doi.org/10.1351/PAC-REC-08-05-02_erratum.

[5] Veronese, F. M.; Mero, A.; Pasut, G. Protein PEGylation, Basic Science and Biological Applications. In PEGylated Protein Drugs: Basic Science and Clinical Applications; Veronese, F. M., Ed.; Milestones in Drug Therapy; Birkhäuser Basel: Basel, 2009; pp 11–31. https://doi.org/10.1007/978-3-7643-8679-5_2.

[6] Jevsevar, S; Kunstejl, M; Porekar, V.G. PEGylation of therapeutic proteins. Biotechnology Journal 2010, 5(1) 113-128. DOI: 10.1002/biot.200900218.

[7] For example, dextran with Đ=2 is considered “low dispersity” today. Previously dextran had even higher dispersity than that. See, Pasut, G. Polymers for Protein Conjugation. Polymers 20146(1), 160–178. https://doi.org/10.3390/polym6010160.

The dPEG®-Biotin Advantage

Biotinylation is one of the most widely used bioconjugation techniques. It can add a biotin tag to antibodies, proteins, and other molecules for high-affinity binding with streptavidin reagents. Our dPEG® spacers create a significant advantage over aliphatic biotin compounds, such as the popular NHS-LC-biotin reagent. The SuperHydrophilic™ dPEG® spacers prevent antibody or protein denaturation, aggregation, or precipitation, which is often a problem when using hydrophobic biotinylation compounds. Discover the dPEG® difference with our water-soluble biotinylation reagents and our wide selection of conjugation chemistries.

Subcategories:
• Amine Reactive dPEG® Biotinylation Reagents
• Biotin-dPEG®x-azide for Click Chemistry
• Biotinidase Resistant Biotin
• Carbonyl Reactive dPEG® Biotinylation Reagents
• Other dPEG® Biotinylation Reagents
• Photoaffinity dPEG® Biotinylation Reagent
• Thiol Reactive dPEG® Biotinylation Reagents

Product Code Name CAS
10825 Biotin-dPEG®₇-azide 956494-20-5
10784 Biotin-dPEG®₁₁-azide dPEG®: 2276672-04-7; Polymer: 956494-20-5
10787 Biotin-dPEG®₂₃-azide 956494-20-5
10201 Biotin-dPEG®₃-MAL dPEG®: 1263044-71-8; Polymer: 525573-2-2
10195 Biotin-dPEG®₁₁-MAL dPEG®: 1646619-56-8; Polymer: 1334172-60-9
10193 Biotin-dPEG®₃-NH₃+TFA- dPEG®: 194920-43-9; Polymer: 1334172-59-6
10196 Biotin-dPEG®₁₁-NH₂ dPEG®: 2407913-93-1; Polymer: 604786-74-5
10826 Biotin-dPEG®₇-NH₂ 1334172-76-7
10786 Biotin-dPEG®₂₃-NH₂ 604786-74-5
11100 Biotin-dPEG®₃-oxyamine. HCl 1951424-88-6
11102 Biotin-dPEG®₁₁-oxyamine. HCl N/A
10785 Biotin-dPEG®₂₃-MAL 1334172-60-9
10308 Biotin-dPEG®₃-TFPA dPEG®: 1263044-14-9; Polymer: 1264662-85-2
10219 Biotin-dPEG®₄-hydrazide 756525-97-0
10356 Biotinoyl-2-Aminobutyric acid dPEG®: 1263044-15-0; Polymer: 917015-56-6
10325 Bis-dPEG®₃-biotin dPEG®: 1263044-47-8; Polymer: 194920-54-2
10199 dPEG®₄-biotin acid dPEG®: 1263044-75-2; Polymer: 721431-18-1
10197 dPEG®₁₂-biotin acid dPEG®: 1621423-14-0; Polymer: 948595-11-7
10773 dPEG®₂₄-biotin acid N/A
10776 dPEG®₄₈-biotin acid N/A
10205 NHS-biotin dPEG®: 85718-04-3; Polymer: 35013-72-0
10200 NHS-dPEG®₄-biotin 459426-22-3
10198 NHS-dPEG®₁₂-biotin dPEG®: 1934296-88-4; Polymer: 365441-71-0
10774 NHS-dPEG®₂₄-biotin 365441-71-0
10202 NHS-dPEG®₄-biotinidase resistant biotin 1334172-61-0
10194 NHS-S-S-dPEG®₄-biotin (cleavable) 1260247-51-5
10203 TFP-dPEG®₄-biotinidase resistant biotin N/A
10204 TFP-dPEG®₁₂-biotinidase resistant biotin N/A
10009 Biotin-dPEG®₄-TFP ester N/A
10008 Biotin-dPEG®₁₂-TFP ester N/A
10007 Biotin-dPEG®₂₄-TFP ester N/A

dPEG® Modification

Discover the dPEG® difference with our broad range of architectures and functional and reactive groups for the chemical modification of small molecules, biomolecules, and nanoparticle surfaces. Improve biocompatibility and increase the water solubility of hydrophobic molecules by adding a discrete dPEG® modifier. Use hydrophilic dPEG® thiolation reagents to create thiols for conjugation. Modify with branched-chain dPEG® reagents to change pharmacokinetics. Coat particle or planar surfaces with dPEG® modification reagents to create functionality and mask underlying hydrophobicity.

Subcategories:
• Amine Reactive dPEG® Reagents
• Branched dPEG® PK Modifiers
• Carboxyl and Active Ester Reactive dPEG® Reagents
• dPEG® Thiolation Reagents: Converting an Amine to a Protected Thiol
• Metal Surface dPEG® Modification Reagents
• Other Reactivities for dPEG® Modifications
• Reagents to Extend Carboxyl with dPEG® Spacers
• SuperHydrophilicTM dPEG® Chemical Modification Reagents
• Thiol Reactive dPEG® Modification Reagents

dPEG® Click Reagents

Whether you need dPEG® compounds for strain-promoted (SPAAC), copper-catalyzed (CuAAC), or ruthenium-catalyzed (RuAAC) reactions, your click chemistry is enabled as never before by our water-soluble, non-immunogenic dPEG® products. Even hydrophobic cyclooctyne compounds are made more hydrophilic by incorporating SuperHydrophilic™ dPEG® linkers. Click now to empower your chemistry!

Subcategories:
• Click dPEG® Azide Crosslinkers
• Click dPEG® Biotinylation Reagents
• Click dPEG® Terminal Alkynes
• Click dPEGylation® Reagents
• Click Fluorescent Dyes
• Copper-Free Click dPEG® Crosslinkers
• Crosslinkers: dPEG® Alkynes
• DBCO-dPEG® Reagents – Hydrophilic Copper-Free Click Reagents

dPEG® Conjugation Reagents:

The process of bioconjugation often uses reactive crosslinkers to couple two molecules together through a crossbridge or linker arm. The use of traditional aliphatic crosslinkers can add unwanted hydrophobicity to modified biomolecules and cause aggregation and nonspecific interactions. By contrast, crosslinking reagents made with our novel, hydrophilic dPEG® groups produce water-soluble compounds, which create conjugates having greater biocompatibility and extremely low nonspecific binding properties.

Our selection of dPEG® crosslinkers includes homobifunctional, heterobifunctional, and branched chain architectures with a wide variety of reactive groups. All of the crosslinkers contain our single molecular weight dPEG® chains as crossbridges. The choice of dPEG® spacers can span molecular lengths from 2 to 48 ethylene glycol repeating units to satisfy virtually any application.

Subcategories:
• Heterobifunctional Reagents: Amine and Thiol Reactive dPEG® Reagents
• Heterobifunctional Reagents: dPEG® Reagents for Hydrazone Bond Formation
• Heterobifunctional: Monoprotected dPEG® Reagents
• Homobifunctional Reagents: Amine Reactive dPEG® Reagents
• Homobifunctional: Diamine and Monoprotected Diamine dPEG® Reagents
• Homobifunctional: Thiol Reactive dPEG® Reagents
• Homohexafunctional: Thiol Reactive dPEG® Reagents
• Homotetrafunctional: Thiol Reactive dPEG® Reagents
• Other Thiol Reactive

Product Code Name CAS
10075 4-formyl-benzamido-dPEG®₁₂-EDA-MAL N/A
10109 Acid-dPEG®₅-NHS ester 1343476-41-4
10119 Acid-dPEG®₉-NHS ester 1895916-27-4
11112 Amino-dPEG®₁₁-ONH-t-boc 1630094-83-5
11338 Bis-Bromoacetamido-dPEG®₁₁ N/A
10724 Bis-dPEG®₂-NHS ester 65869-63-8
10726 Bis-dPEG®₃-NHS ester 1314378-16-9
10224 Bis-dPEG®₅-NHS ester 756526-03-1
10988 Bis-dPEG®₇-NHS ester 1334170-02-3
10246 Bis-dPEG®₉-NHS ester 1008402-79-6
10954 Bis-dPEG®₁₃-NHS ester dPEG®: 2221949-00-2; Polymer: 1008402-79-6
10979 Bis-dPEG®₁₇-NHS ester dPEG®: 2221948-93-0; Polymer: 1008402-79-6
10981 Bis-dPEG®₂-PFP ester 1314378-18-1
10956 Bis-dPEG®₂₁-NHS ester dPEG®: 2221948-98-5; Polymer: 1008402-79-6
10968 Bis-dPEG®₂₅-NHS ester dPEG®: 2221948-96-3; Polymer: 1008402-79-6
10982 Bis-dPEG®₃-PFP ester 1314378-13-6
10015 Bis-dPEG®₅-PFP ester 1334177-78-4
10230 Bis-dPEG®₅-acid 439114-13-3
10237 Bis-dPEG®₅, half benzyl half NHS ester 1263044-84-3
10236 Bis-dPEG®₇-acid 94376-75-7
10987 Bis-dPEG®₇-PFP ester 1334170-01-2
10967 Bis-dPEG®₂₅-acid dPEG®: 2221948-96-3; Polymer: 1268488-70-5
10320 Bis-dPEG®₂₉-acid N/A
10983 Bis-dPEG®₉-PFP ester 1334170-00-1
10215 Bis-MAL-dPEG®₃ 756525-89-0
10397 Bis-MAL-dPEG®₁₁ 854753-78-9
10630 Bis-MAL-Lysine-dPEG®₄-acid 2307731-13-9
10631 Bis-MAL-Lysine-dPEG®₄-TFP ester 2173083-46-8
10232 Bis-Maleimide amine,TFA salt 1301738-40-8
11200 Bromoacetamido-dPEG®₄-TFP ester 2247993-78-6
11202 Bromoacetamido-dPEG®₁₂-TFP ester N/A
11434 Bromoacetamido-dPEG®₁₂-Tris(-dPEG®₁₁-bromoacetamide)₃ N/A
11203 Bromoacetamido-dPEG®₂₄-TFP ester N/A
10269 CBZ-N-amido-dPEG®₃-amine 220156-99-0
10361 Diamido-dPEG®₁₁-diamine 1224728-09-9
11436 Hexa(-amido-dPEG®₁₁-MAL)dipentaerythritol N/A
10265 MAL-dPEG®₂-acid 756525-98-1
10338 MAL-dPEG®₄-acid 1263045-16-4
10065 MAL dPEG®₆-acid 1334177-79-5
10275 MAL-dPEG®₈-acid 1334177-86-4
10285 MAL-dPEG®₁₂-acid dPEG®: 2378428-27-2; Polymer: 871133-36-7
11433 MAL-dPEG®₁₂-Tris(-dPEG®₁₁-amido-MAL)₃ N/A
10266 MAL-dPEG®₂-NHS ester 955094-26-5
10549 MAL-dPEG®₂-TFP ester 1431291-44-9
10315 MAL-dPEG®₂₄-acid dPEG®: 2171095-70-6; Polymer: 871133-36-7
10214 MAL-dPEG®₄-NHS ester 756525-99-2
10064 MAL-dPEG®₆-NHS ester 1137109-21-7
10274 MAL-dPEG®₈-NHS ester 756525-93-6
10284 MAL-dPEG®₁₂-NHS ester dPEG®: 2101722-60-3; Polymer: 756525-92-5
10210 MAL-dPEG®₄-t-boc-hydrazide 1127247-28-2
10551 MAL-dPEG®₄-TFP ester 1807540-84-6
10556 MAL-dPEG®₆-TFP ester N/A
10962 MAL-dPEG®₁₂-t-boc-hydrazide 1334169-99-1
10552 MAL-dPEG®₈-TFP ester 1924596-31-5
10553 MAL-dPEG®₁₂-TFP ester N/A
10554 MAL-dPEG®₂₄-TFP ester 2384191-62-0
10555 MAL-dPEG®₃₆-TFP ester N/A
11303 MAL-dPEG®₂₄-amido-dPEG®₂₄-TFP ester N/A
10217 MPS (NHS-3-maleimidopropionate) 55750-62-4
10323 MPS-Acid 7423-55-4
10374 SPDP-dPEG®₄-NHS ester 1334177-95-5
10376 SPDP-dPEG®₈-NHS ester 1252257-56-9
10378 SPDP-dPEG®₁₂-NHS ester 924280-65-9
10375 SPDP-dPEG®₈-acid 1334177-96-6
10377 SPDP-dPEG®₁₂-acid 1334177-97-7
10380 SPDP-dPEG®₂₄-acid 1334177-97-7
10379 SPDP-dPEG®₂₄-NHS ester 924280-65-9
10866 SPDP-dPEG®₃₆-acid 1334177-97-7
10867 SPDP-dPEG®₃₆-NHS ester 924280-65-9
10225 t-boc-N-amido-dPEG®₃-amine 194920-62-2
10226 t-boc-N-EDA 57260-73-8
11435 Tetra(-amido-dPEG®₁₁-MAL)pentaerythritol N/A
11414 Tetra(-amido-dPEG®₂₃-MAL)pentaerythritol N/A
10177 MPS-EDA.TFA dPEG®: 1301739-85-4; Polymer: 11550-02-00
10014 Tris (2-carboxyethyl) phosphine hydrochloride (TCEP) 51805-45-9
10041 Amino-dPEG®₄-t-boc-hydrazide 1263047-17-1
10957 Amino-dPEG®₈-t-boc-hydrazide 1334169-96-8
10958 Amino-dPEG®₁₂-t-boc-hydrazide 1334169-97-9
10085 Bis-dPEG®₄-TFP ester 1446282-42-3
10043 Fmoc-N-amido-dPEG®₄-t-boc-hydrazide 1263044-77-4
10011 Phthalimidooxy-dPEG®₄-NHS ester 1415328-95-8
11135 Phthalimidooxy-dPEG®₁₂-NHS ester N/A
10984 Bis-dPEG®₁₃-PFP ester dPEG®: 1383567-59-6; Polymer: 1334170-00-1
10980 Bis-dPEG®₁₇-PFP ester 1334170-00-1
10985 Bis-dPEG®₂₁-PFP ester 1334170-00-1
10314 MAL-dPEG®₂₄-NHS ester dPEG®: 2226733-37-3; Polymer: 756525-92-5
10172 t-boc-N-amido-dPEG®₁₁-amine dPEG®: 1233234-77-9; Polymer: 198227-38-2
10081 4-formyl-benzamido-dPEG®₁₂-TFP ester N/A
10093 t-boc-N-amido-dPEG®₂₃-amine N/A
10127 Acid-dPEG®₁₃-NHS ester 2152679-62-2
10082 4-formyl-benzamido-dPEG®₂₄-TFP ester N/A
10140 Acid-dPEG®₂₅-NHS ester N/A
10092 Bis-dPEG®₂₅-TFP ester N/A

dPEG® Fluorescent Dyes and Haptens

Dyes and hapten labeling reagents made with our SuperHydrophilic™ dPEG® compounds are revolutionizing the labeling of antibodies and other proteins. Traditional fluorescent dyes and haptens can be extremely hydrophobic, which can result in antibody instability, aggregation, and high nonspecific background in assays or detection applications.

Our growing line of dPEG®-modified fluorescent dyes changes everything. The addition of dPEG® tethers to the core dye structure results in extreme water solubility and biocompatibility for modified antibodies or other molecules. This means that you can label with more dyes for greater fluorescence intensity without causing antibody instability or nonspecific binding.

Our dPEG® dyes are brighter and display greater specificity toward targets than the previous generation of dyes. Revolutionize your labeled antibodies today with dPEG® Fluorescent Dyes and Haptens.

Subcategories:
• Carboxyfluorescein-dPEG®₁₂-NHS ester
• DNP-dPEG®x-acid
• DNP-dPEG®x-NHS ester

Product Code Name CAS
10885 Carboxyfluorescein-dPEG®₁₂-NHS ester N/A
10346 DNP-dPEG®₄-acid 858126-76-8
10398 DNP-dPEG®₁₂-acid 1334178-00-5
10347 DNP-dPEG®₄-NHS ester 858126-78-0
10399 DNP-dPEG®₁₂-NHS ester 1334178-01-6

dPEG® Delivery Reagents:

Quanta BioDesign’s line of payload delivery reagents includes three important product categories: DOTA-dPEG® bifunctional chelators, Phospholipid dPEG® derivatives; and our exclusive Sidewinder™ dPEG® constructs. Our DOTA products are useful for targeted radioimaging and radiotherapy applications with labeled antibodies. We designed the phospholipid category of products for use as liposomal and micellar drug delivery vehicles. In addition, our unique Sidewinder™ product line permits highly controlled construction of drug delivery systems with high drug-to-antibody ratios (DARs). With all of these delivery agents, “the dPEG® difference” provides enhanced hydrophilicity and biocompatibility so that modified antibodies retain stability and display low nonspecificity.

Subcategories:
• DOTA-dPEG® Bifunctional Chelators with Adjustable Hydrophilic Linker Lengths
• Phospholipid dPEG® Derivatives
• Sidewinder™ dPEG® Constructs

Product Code Name
11153 DOTA tris(TBE)-amido-dPEG®₂₃-bromo acetamide Sodium Bromide
11386 Biotin-dPEG®₄-amido-dPEG®₂₄-amido-dPEG®₂₄-DSPE
11385 Carboxyfluorescein-dPEG®₂₄-amido-dPEG®₂₄-DSPE
11383 DBCO-dPEG®₂₄-amido-dPEG®₂₄-DSPE
11166 DOTA-tris(TBE)-amido dPEG®₁₁-Maleimide
11170 DOTA-tris(TBE)-amido-dPEG®₂₃-Maleimide
11150 DOTA-tris(acid)-amido-dPEG®₃-bromoacetamide
11152 DOTA-tris(acid)-amido-dPEG®₁₁-bromoacetamide
11167 DOTA-tris(acid)-amido-dPEG®₁₁-Maleimide
11160 DOTA-tris(acid)-amido-dPEG®₄-TFP ester
11162 DOTA-tris(acid)-amido-dPEG®₁₂-TFP ester
11154 DOTA-tris(acid)-amido-dPEG®₂₃-bromoacetamide
11171 DOTA-tris(acid)-amido-dPEG®₂₃-Maleimide
11384 DOTA-tris(acid)-amido-dPEG®₂₄-amido-dPEG®₂₄-DSPE
11163 DOTA-tris(acid)-amido-dPEG®₂₄-TFP ester
11155 DOTA-tris(TBE)-amido-dPEG®₄-TFP ester
11157 DOTA-tris(TBE)-amido-dPEG®₁₂-TFP ester
11158 DOTA-tris(TBE)-amido-dPEG®₂₄-TFP ester
11024 m-dPEG®₈-DSPE
11025 m-dPEG®₁₂-DSPE
11026 m-dPEG®₂₄-DSPE
11094 m-dPEG®₁₂-amido-dPEG®₂₄-DSPE
11095 m-dPEG®₂₅-amido-dPEG®₂₄-DSPE
11597 MAL-[NH-dPEG®₄-Glu(TFP ester)]₃-NH-m-dPEG®₂₄
11028 MAL-dPEG®₁₂-DSPE
11093 MAL-dPEG®₂₄-amido-dPEG®₂₄-DSPE
11388 MAL-dPEG®₂₄-amido-dPEG®₂₄-amido-dPEG®₂₄-DSPE
11580 MAL-dPEG®₄-Glu(OH)-NH-m-dPEG®₂₄
11626 MAL-dPEG®₄-Glu(TFP ester)-NH-dPEG®₄-Glu(TFP ester)-NH-m-dPEG®₂₄
11581 MAL-dPEG®₄-Glu(TFP ester)-NH-m-dPEG®₂₄
11577 MAL-dPEG®₄-Lys(-5(6)-Carboxyfluorescein)-NH-m-dPEG®₂₄
11575 MAL-dPEG®₄-Lys(t-boc)-NH-m-dPEG®₂₄
11576 MAL-dPEG®₄-Lys(TFA-)-NH-m-dPEG®₂₄
11373 Methoxy-dPEG®₂₅-DSPE
11644 NH₂-dPEG®₄-Glu(OH)-[NH-dPEG®₄-Glu(OH)]₂-NH-m-dPEG®₂₄
11624 NH₂-dPEG®₄-Glu(OH)-NH-dPEG®₄-Glu(OH)-NH-m-dPEG®₂₄
11643 NH₂-dPEG®₄-Glu(OH)-NH-m-dPEG®₂₄
11598 NH₂-dPEG®₄-Lys(t-boc)-NH-m-dPEG®₂₄
11029 TFP-dPEG®₁₃-DSPE

dPEG® Building Blocks:

Quanta BioDesign’s popular line of dPEG® building blocks provides SuperHydrophilic™ linkers of various molecular sizes and designs. The reagents contain reactive groups or protected functional groups for almost any application. They can be used to modify particles, create linker arms during peptide or oligonucleotide synthesis, or construct drug payload designs for antibody-drug conjugates (ADCs).

Our peptide modification products offers Cbz-, Fmoc-, and boc-protected amino-dPEG®x-acid compounds. Some of our Fmoc-protected products are available as preactivated (NHS or TFP esters) products. We also provide methoxytrityl-protected thiol compounds that permit conversion of an amine to a thiol and Fmoc-protected aminooxy products for customers who need to form oxime bonds. Finally, we offer two novel products that permit easy insertion of a biotin label into a peptide chain. Discover “the dPEG® difference” with Quanta BioDesign’s line of unique building blocks.

Subcategories:
• Amino-dPEG®₁₂-ODMT
• CBZ-N-amido-dPEG®x-acid
• Fmoc-N-amido-dPEG®x-acid
• Fmoc-N-amido-dPEG®x-NHS ester
• Fmoc-N-amido-dPEG®x-TFP ester
• Fmoc-N-Lys-(dPEG®x-biotin)-OH-(acid)
• Methoxytrityl-S-dPEG®x-acid
• t-boc-N-amido-dPEG®x-acid

Product Code Name CAS
10342 Amino-dPEG®₁₂-ODMT 879571-23-0
10268 CBZ-N-amido-dPEG®₄-acid 756526-00-8
10066 CBZ-N-amido-dPEG®₆-acid 1334177-80-8
10276 CBZ-N-amido-dPEG®₈-acid 1334177-87-5
10286 CBZ-N-amido-dPEG®₁₂-acid 1334177-88-6
10316 CBZ-N-amido-dPEG®₂₄-acid 1334177-88-6
10906 CBZ-N-amido-dPEG®₃₆-acid 1334177-88-6
11000 Fmoc-N-amido-dPEG®₄-TFP ester 2247993-77-5
11005 Fmoc-N-amido-dPEG®₈-TFP ester N/A
11006 Fmoc-N-amido-dPEG®₁₂-TFP ester N/A
10243 Fmoc-N-amido-dPEG®₂-acid 872679-70-4
11007 Fmoc-N-amido-dPEG®₂₄-TFP ester N/A
10033 Fmoc-N-amido-dPEG®₃-acid 867062-95-1
11008 Fmoc-N-amido-dPEG®₃₆-TFP ester N/A
10213 Fmoc-N-amido-dPEG®₄-acid 557756-85-1
10994 Fmoc-N-amido-dPEG®₄-NHS ester 1314378-14-7
10995 Fmoc-N-amido-dPEG®₈-NHS ester 1334170-03-4
10996 Fmoc-N-amido-dPEG®₁₂-NHS ester dPEG®: 2227246-92-4; Polymer: 488085-18-3
10613 Fmoc-N-Lys-(dPEG®₄-biotin)-OH-(acid) 1334172-64-3
10615 Fmoc-N-Lys-(dPEG®₁₂-biotin)-OH-(acid) 1334172-65-4
10301 Methoxytrityl-S-dPEG®₄-acid 1263047-31-9
10220 t-boc-N-amido-dPEG®₄-acid 756525-91-4
10760 t-boc-N-amido-dPEG®₈-acid 1334169-93-5
10761 t-boc-N-amido-dPEG®₁₂-acid dPEG®: 1415981-79-1; Polymer: 187848-68-6
10763 t-boc-N-amido-dPEG®₂₄-acid 187848-68-6
10902 t-boc-N-amido-dPEG®₃₆-acid 187848-68-6
10053 Fmoc-N-amido-dPEG®₅-acid 882847-32-7
11304 CBZ-amido-dPEG®₂₄-amido-dPEG®₂₄-acid N/A
10063 Fmoc-N-amido-dPEG®₆-acid 882847-34-9
10273 Fmoc-N-amido-dPEG®₈-acid 756526-02-0
10283 Fmoc-N-amido-dPEG®₁₂-acid dPEG®: 1952360-91-6; Polymer: 756526-01-9
10313 Fmoc-N-amido-dPEG®₂₄-acid dPEG®: 2170484-59-8; Polymer: 756526-01-9
10903 Fmoc-N-amido-dPEG®₃₆-acid 756526-01-9
11301 Fmoc-amido-dPEG®₂₄-amido-dPEG®₂₄-acid N/A
10166 Methoxytrityl-S-dPEG®₈-acid 1334177-82-0
10846 Methoxytrityl-S-dPEG®₁₂-acid 1334169-94-6

SNARE-Mediated Membrane Fusion and dPEG®, Part 1

Contact Us Part 1: A Reduced SNARE Model for Membrane Fusion The cells of all living things depend on membrane Read More...

SNARE-Mediated Membrane Fusion and dPEG®, Part 2

Contact Us Part 2: Controlling Liposome Fusion Using SNARE Protein Mimics For Part 1 of this three-part series, click here. For Read More...

SNARE-Mediated Membrane Fusion and dPEG®, Part 3

Contact Us Part 3: Modeling Membrane Fusion with SNARE Protein Analogs   Click the links for Part 1 and Part 2 of this three-part Read More...

Marvelous Maleimide Crosslinker Products

View All Quanta Biodesign ProductsHow to Order This review discusses Quanta BioDesign's maleimide crosslinker products - what they do and Read More...

Extracellular Drug Conjugates Therapeutically Exploit Protein Proximity

View All Quanta Biodesign ProductsHow to Order Pharmaceutical company Centrose, founded by James R. Prudent, Ph.D., developed a new class of antibody drug Read More...

Three Click Chemistry Crosslinking Ideas with dPEG®

View all Quanta Biodesign ProductsHow to Order Have you ever been working your way through a product catalog when you've Read More...

Copper-free Click Chemistry to Crosslink Azides and Amines

View All Quanta Biodesign ProductsHow to Order Quanta BioDesign’s monodispersed, discrete PEG (dPEG®) products include a wide range of useful Read More...

Aminooxy-dPEG®11-azide: A New Click Chemistry Crosslinker

View All Quanta Biodesign ProductsHow to Order Quanta BioDesign, Ltd. is proud to announce that our newest click chemistry crosslinker, Aminooxy-dPEG®11-azide∙HCl, Read More...