Since its formation in 1982 dianova has provided the scientific community with antibodies, immunoassays and other life science reagents.
Dianova developes a proprietary product line that integrates selected antibodies with unique features for staining FFPE tissues.
By collaborating with both pathology institutes and contact in academia, Dianova are able to expand the range of unique antibodies for IHC applications.

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Dianova developes and manufactures a proprietary line of antibodies for immunostaining of standard formalin-fixed paraffin-embedded tissue. Dianova antibodies allow powerful laboratory analyses with brilliant results. With their key contacts in German pathological institutes and in close collaboration with academic institutes Dianova will gradually expand the IHC range with the addition of new, unique antibody clones.

Anti-IDH1 R132H antibody, clone H09 (Cat DIAH09), has attracted enormous interest among Neuropathologists and has lead to reorganization of the WHO Classification of Tumors of the Central nervous system in 2016. This unique, point mutation specific antibody is an essential tool for Neuropathological laboratories, allowing differentiation between reactive gliosis and low grade glioma. This antibody enables the detection of single infiltrating tumour cells.

Antibody clone SZ31 (Cat DIA310), is the only anti-CD31 antibody available worldwide that is effective on standard-formalin fixed paraffin-embedded mouse tissue. This makes this antibody extremely important as an Endothelial cells marker for research and preclinical studies of Angiogenesis in mouse models, e.g. human tumour xenografts.

Another unique product is the anti-Calreticulin Mutation specific monoclonal antibody CAL2. It allows the immunohistochemical detection of all types of CALRETICULIN mutations in FFPE bone marrow sections for the first time (Stein et al. Leukemia, 2015). CAL2 immunohistochemistry is a sensitive, rapid and cost-effective method to identify all CALR mutations in Myeloproliferative Neoplasms.

Another key product is the anti-His-Tag antibody (Cat DIA900), which has an unequaled high sensitivity (Biacore 3x 10-10M) when compared to other available clones.

Focus on quality

Since its foundation dianova has attached great importance to quality. This applies to the products, to internal structures and processes as well as to employees and services. At dianova quality is a management issue and constitutes an integral part of all our work flows and is continuously improved.

Increasing customer satisfaction is the main motivation for the continuous optimization of the processes, the competence of the staff, the enhancement of the services, the quality of dianovas partner companies and the high standard of the products.

Quality for you

Our customers are our main motivation with regard to these efforts in all work areas. The continuous optimization of our processes, the competence of our staff, the enhancement of our services, the quality of our partner companies and the high standard of our products are aimed at contributing to a good cooperation with you. We believe that this is the best way to improve customer satisfaction.

Locally anchored, globally connected, internationally known
dianova is a member of various national societies in life sciences and diagnostics, of regional alliances, and international networking platforms of biotech companies like the PSL Alliance. Through our international distributors and the listing of our antibodies on different portals dianova products are known worldwide.

Quality assurance

All products in our range are procured from manufacturers or production labs regularly inspected by dianova. These inspections ensure that our partners maintain adequate structures and procedures for good manufacturing practice. Accordingly, many partners hold ISO certificates. Another quality assurance measure is the random sampling of reagents in independent test labs. Moreover, dianova’s internal control system ensures that cumulative deficiencies are recognized immediately, customers affected are notified and remedy measures are implemented in production.

Adequate production and quality assurance processes at the manufacturer’s premises guarantee that the reagents function in the immune detection methods and species specified in the data sheet. Insofar as a dianova product has been correctly selected and applied by the user to the detection system and sample material, the results will be correct.

In the event that dianova’s antibodies and reagents do not meet the properties specified in the data sheet in whole or in part, we will initiate suitable measures. This procedure shall be precluded if a product has been used in an application which has not been confirmed yet as specified in the data sheet or a product has been selected or treated incorrectly.

In such a case we require comprehensive information to find the optimum solution For efficient support please keep the following details ready: catalog number, date of purchase, batch number, product storage (temperature, with/without additives, aliquoting), blockage, antibody, detection system, solutions, thinners, incubation times and temperatures as well as details with regard to positive or negative controls. This will enable our experts to provide you with suitable recommendations or offer the best replacement.

Anti-CALRmut antibody CAL2 for IHC detection of all CALRETICULIN mutations in MPNs

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Monoclonal Antibodies

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Classification of diffuse Gliomas

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First for Antibodies

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Anti-IDH1 R132H (clone H09) Clinical Relevance

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Anti-IDH1 R132H antibody clone H09

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IDH Mutations

IDH mutations in glioblastoma and low-grade glioma In 2008 whole genome analysis of human glioblastomas led to the discovery of Read More…

Resisting Cell Death

In order to survive and proliferate, cancer cells must overcome and avoid the diverse range and number of cell death Read More…