Selleck Chemicals

A world leading supplier of high performance validated Life Science reagents and reference compounds for non-clinical research.

Selleck have over 3000 inhibitors used in the study of cell signalling pathways and their bioactive screening libraries consist of over 2100 small molecules.

The safety and effectiveness of these molecules has been demonstrated through pre-clinical research and many are FDA approved compounds.


Product Categories
by Signalling Pathways

DNA Damage

  • HDAC
  • ATM/ATR
  • PARP
  • DNA/RNA Synthesis
  • Sirtuin
  • Topoisomerase
  • DNA-PK
  • Telomerase
  • MTH1
  • DNA alkylator

PI3K/Akt/mTOR

  • PI3K
  • mTOR
  • Akt
  • GSK-3
  • ATM/ATR
  • PDK
  • S6 Kinase
  • AMPK
  • DNA-PK
  • MELK

Apoptosis

  • Bcl-2
  • Caspase
  • p53
  • TNF-alpha
  • Mdm2
  • Survivin
  • c-RET
  • IAP
  • PD-1/PD-L1
  • PERK

Cell Cycle

  • CDK
  • Aurora Kinase
  • Chk
  • ROCK
  • PLK
  • APC
  • Wee1
  • Rho
  • c-Myc
  • PD-1/PD-L1
  • DYRK

Cytoskeletal Signaling

  • Akt
  • Bcr-Abl
  • Wnt/beta-catenin
  • PKC
  • FAK
  • HSP (e.g. HSP90)
  • Kinesin
  • Microtubule Associated
  • Integrin
  • PAK
  • Dynamin

Proteases

  • Proteasome
  • Caspase
  • Gamma-secretase
  • HCV Protease
  • DPP-4
  • HIV Protease
  • MMP
  • Cysteine Protease
  • Serine Protease
  • Tyrosinase
  • Glutaminase

Endocrinology & Hormones

  • 5-alpha Reductase
  • Estrogen/progestogen Receptor
  • Androgen Receptor
  • RAAS
  • Opioid Receptor
  • Aromatase
  • GPR
  • Glucocorticoid Receptor

Transmembrane Transporters

  • Calcium Channel
  • Sodium Channel
  • ATPase
  • Potassium Channel
  • GABA Receptor
  • P-gp
  • Proton Pump
  • CFTR
  • TRPV
  • CRM1
  • OCT

Microbiology

  • HCV Protease
  • Integrase
  • Reverse Transcriptase
  • CCR
  • HIV Protease
  • Antifection

Stem Cells & Wnt

  • GSK-3
  • JAK
  • STAT
  • TGF-beta/Smad
  • Wnt/beta-catenin
  • ROCK
  • Gamma-secretase
  • Hedgehog/Smoothened
  • Casein Kinase
  • Hippo pathway

Autophagy

  • Autophagy
  • CXCR
  • LRRK2

JAK/STAT

  • JAK
  • STAT
  • EGFR
  • Pim

MAPK

  • MEK
  • Raf
  • p38 MAPK
  • JNK
  • ERK
  • MNK

Ubiquitin

  • Proteasome
  • DUB
  • E3 Ligase
  • p97
  • E2 conjugating
  • E1 Activating

NF-κB

  • HDAC
  • NF-κB
  • IκB/IKK
  • NOD1

Angiogenesis

  • VEGFR
  • JAK
  • EGFR
  • PDGFR
  • HER2
  • FLT3
  • FGFR
  • HIF
  • VDA
  • Bcr-Abl
  • Src
  • ALK
  • Syk
  • FAK
  • BTK

Immunology & Inflammation

  • COX
  • CCR
  • Histamine Receptor
  • IL Receptor
  • gp120/CD4
  • CXCR
  • PD-1/PD-L1
  • MALT
  • Immunology & Inflammation related
  • LTR
  • ROS
  • NOS
  • TLR
  • NADPH oxidase
  • Nrf2

Epigenetics

  • HDAC
  • PARP
  • JAK
  • Pim
  • HIF
  • Aurora Kinase
  • Sirtuin
  • DNA Methyltransferase
  • Histone Methyltransferase
  • Epigenetic Reader Domain
  • Histone Demethylase
  • Histone Acetyltransferase

GPCR & G Protein

  • 5-HT Receptor
  • Adrenergic Receptor
  • Histamine Receptor
  • Dopamine Receptor
  • Opioid Receptor
  • Cannabinoid Receptor
  • Endothelin Receptor
  • S1P Receptor
  • Hedgehog/Smoothened
  • SGLT
  • LPA Receptor
  • OX Receptor
  • CGRP Receptor
  • MT Receptor
  • PAFR
  • PKA
  • CaSR
  • CXCR
  • Vasopressin Receptor
  • cAMP
  • Adenosine Receptor

Protein Tyrosine Kinase

  • VEGFR
  • EGFR
  • PDGFR
  • c-Met
  • HER2
  • IGF-1R
  • FLT3
  • FGFR
  • c-Kit
  • Src
  • ALK
  • Tie-2
  • c-RET
  • TAM Receptor
  • CSF-1R
  • Ephrin receptor
  • Trk receptor
  • ACK

Neuronal Signaling

  • Beta Amyloid
  • 5-HT Receptor
  • COX
  • Gamma-secretase
  • GluR
  • Adrenergic Receptor
  • AChR
  • Histamine Receptor
  • Dopamine Receptor
  • Opioid Receptor
  • GABA Receptor
  • P-gp
  • P2 Receptor
  • OX Receptor
  • MT Receptor
  • BACE
  • Substance P
  • NMDAR
  • CaMK
  • GlyT

Metabolism

  • PPAR
  • P450 (e.g. CYP17)
  • HSP (e.g. HSP90)
  • PDE
  • Hydroxylase
  • Factor Xa
  • DHFR
  • Dehydrogenase
  • Procollagen C Proteinase
  • Phospholipase (e.g. PLA)
  • Carbonic Anhydrase
  • MAO
  • FAAH
  • CETP
  • Transferase 
  • Ferroptosis
  • HMG-CoA Reductase
  • FXR
  • IDO
  • Retinoid Receptor
  • Lipase
  • Lipoxygenase
  • Vitamin
  • AhR
  • Casein Kinase
  • NAMPT
  • Thioredoxin
  • Decarboxylase
  • GLUT1

 

 

TGF-beta/Smad

  • TGF-beta/Smad
  • Bcr-Abl
  • PKC
  • ROCK

Others

  • Phosphorylase
  • Thrombin
  • Liver X Receptor
  • Others
  • PTEN
  • phosphatase

Screening Libraries

 
Bioactive Compound Library

2658 bioactive compounds

 
Kinase Inhibitor Library

A unique collection of 429 kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).

 
FDA-approved Drug Library

1443 FDA-approved drugs

 
Express-Pick Library

4208 compounds featured different parent nuclei and structurally diverse respectively.

 
Inhibitor Library

A unique collection of 1694 inhibitors for high throughput screening (HTS) and high content screening (HCS).

 
Epigenetics Compound Library

A unique collection of 181 small molecule modulators with biological activity used for epigenitc research.

 
Target Selective Inhibitor Library

A unique collection of validated bioactive compounds covering over 174 targets.

 
Natural Product Library

A unique collection of 133 natural products for high throughput screening (HTS) and high content screening (HCS).

 
GPCR Compound Library

A unique collection of 280 GPCR small molecule compound library for GPCR screening.

 
Anti-cancer Compound Library

A unique collection of 422 anti-cancer compounds under clinical trials

 
Tyrosine Kinase Inhibitor Library

A unique collection of 171 tyrosine kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).

 
Stem Cell Signaling Compound Library

A unique collection of 88 small molecule inhibitors used for stem cell regulatory and signaling pathway research.

 
Cambridge Cancer Compound Library

A unique collection of 267 anti-cancer compounds

 
Pfizer Licensed Compound Library

 

 
Autophagy Compound Library

 A unique collection of 154 autophagy signaling pathway inhibitors

 
Ion Channel Ligand Library

 A unique collection of 63 ion channel ligands

 
PI3K/Akt Inhibitor Library

 A unique collection of 118 PI3K signaling pathway inhibitors

 
Apoptosis Compound Library

A unique collection of 101 small molecules used for apoptosis research targeting Bcl-2,Caspase,p53,TNF-alpha,Mdm2,survivin, etc.

 
MAPK Inhibitor Library

 A unique collection of 61 small molecule inhibitors used for MAPK signaling research.

 
Protease Inhibitor Library

 A unique collection of 53 small molecule inhibitors used for chemical genomics, high-throughput screening (HTS), and high content screening (HCS).

 
Anti-infection Compound Library

 A unique collection of 142 anti-infective small molecules with biological activity of antibiotics,antifungal drugs,anti-HIV,etc.

 
Anti-diabetic Compound Library

 A unique collection of 33 small molecules affecting the development of diabetes.

 

 


selleck-catalog

Order you Signal Pathway Catalog from us FREE. info@stratech.co.uk

Selleck Chemicals is one of the world leading suppliers of high-performance life-science reagents and reference compounds for the non-clinical research field.  They are dedicated to and focused on the more complex research biochemicals and aim to provide the most innovative range of research reagents at the most competitive price.  Products include Aurora Kinase Inhibitors, Bcl-2 Protein Family Inhibitors, c-Met Inhibitors, HDAC Inhibitors, IGF-1R Inhibitors, PI3K/AKT Inhibitors and many, many more.

Selleck Chemicals pay great attention to the purity, stability and activity of their compounds, especially those that historically have subtle purity and stability problems.  With a well-established Internal & External Quality Control system, not only can Selleck Chemicals provide the chemical test data, such as HNMR, LC-MS and HPLC, but also test reports obtained from experiments with their own compounds, such as Western Blot & RT-PCR, which provide a double guarantee of the biological activity of their compounds in life-science research.

Additional Information

 


Abbreviations

Selleck Abbreviations

Routes of drug administration Route Abbreviation Description Intracerebroventricular i.c.v. Into the ventricles of the brain Intra-arterial i.a. Into the lumen Read More…

Screening Library – Epigenetics Compound Library

A unique collection of 119 small molecule modulators with biological activity used for epigenitc research. Epigenetics Compound Library – All Read More…

Pharmacological Glossary

Definitions of Commonly Used Pharmacological Terms Absorbance Absorbance is used for assays such as ELISA assays, protein and nucleic acid Read More…

Cell Cycle

  The cell cycle and cell cycle-associated proteins play essential roles in cell fate, including cell replication, cell death, and Read More…

MAPK

MAPK (mitogen-activated protein kinase) is a family of serine-threonine kinases that regulate multiple cellular functions such as mitogens, proinflammatory cytokines, Read More…

PI3K/Akt/mTOR

Selleck Chemicals – PI3K/Akt/mTOR | Stratech Scientific Ltd Selleck Chemicals provides products of the following targets: PI3K mTOR Akt GSK-3 Read More…

Resisting Cell Death

In order to survive and proliferate, cancer cells must overcome and avoid the diverse range and number of cell death Read More…

Cell Culture

Overview Cell culture is an important tool that is used throughout biomedical science. It is used in basic science to Read More…

Inhibitors of the PI3K/Akt/mTOR Signalling Pathway

Selleck Chemicals is one of the worlds leading suppliers of high-performance inhibitors and reference compounds for non-clinical research fields focusing Read More…