The conventional approach to commercial antibody production has improved remarkably since its inception well over 40 years ago. The development of reliable antibody reagents remains an essential goal in the quest to advance science and medicine. On the forefront of high-quality antibody manufacturing, GeneTex has solidified its position in the research community and the biotechnology industry.


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Quality

With a 20-year history of quality results, GeneTex sets itself apart from other antibody companies by taking the necessary steps to properly validate our antibodies. Antibody validation remains an industry-wide challenge with ramifications that can impact progress in the life sciences and medicine.

At GeneTex, product reliability is our primary concern. Stringent validation protocols have been established to test our antibodies for various applications, including WB, IP, IHC, IFA, FACS, and ELISA, using cell lines with known target protein expression levels and a diverse array of tissue samples. We know the importance of replicating results, so quality consistency between lots is maintained confidently through a combination of pre-qualified individual lots, dominant clones, and thorough quality control.

Founded by scientists, for scientists, we at GeneTex understand that researchers expect and demand product performance and fidelity. With GeneTex’s Knockout/Knockdown validation project, we’re committed to demonstrating to our customers that the products they are purchasing are completely reliable, every single time.

Our Commitment

There has been growing distrust of commercially available antibodies with regard to specificity and performance variability. As a result, the research community has demanded that antibody suppliers increase their efforts to more thoroughly validate their products. One approach to address this is through knockout or knockdown of the target protein.

At GeneTex, we continue to provide the research community with the highest quality and most stringently validated antibodies by utilizing CRISPR/Cas9- and shRNA-generated cell lysates for our western blot assays. To date, we have evaluated most of our featured products and will continue to expand these efforts throughout our entire antibody catalogue.

GeneTex primary antibodies have been tested through the use of various analytic strategies to ensure persistent quality and confirm antibody specificity. Based on the guidelines described by the International Working Group on Antibody Validation (IWGAV), GeneTex has been employing multiple approaches to certify antibody performance in our quality assurance process.

 

See GeneTex’s Validation Methods
GeneTex understands the absolute necessity for reliable antibodies to achieve accurate and reproducible experimental results. To optimize the performance of our reagents, we employ various analytic validation strategies to ensure both consistent quality (see GeneTex’s Approach to Antibody Lot-to-Lot Variability) and specificity. These modalities are in line with guidelines described by the International Working Group on Antibody Validation (IWGAV) and have become fundamental components of our quality assurance process:

Polyclonal Antibodies

Polyclonal antibodies generated by an immunized animal consist of a heterogeneous mix of immunoglobulins derived from many B-cells that individually target distinct epitopes on an antigen. Often representing up to 5% of the total immunoglobulin, these antibodies are generally purified from the immune sera using antigen-affinity chromatography. Polyclonal antibodies are particularly useful for detecting proteins that are expressed at lower levels, and their performance is impacted to a lesser degree by alterations in the antigen (e.g., denaturation). GeneTex offers an extensive catalog of affinity-purified polyclonal antibodies directed against almost all key targets/proteins in the spectrum of biomedical research.

Monoclonal Antibodies

Monoclonal antibodies are produced by immortal hybridoma cells created from the fusion of antibody-producing splenic B-cells and myeloma cells, or by recombinant protein expression in mammalian cells. These antibodies have monovalent affinity and bind to a single epitope on the antigen. Purification is commonly accomplished through Protein A/G/L affinity chromatography.GeneTex offers a broad selection of monoclonal antibodies directed against the majority of key targets/proteins in the spectrum of biomedical research.

Exosome Research

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Epitope Tags & Reporters

Epitope tags are peptide or protein sequences covalently conjugated, usually to the C- or N-terminus, of a recombinant protein. The Read More...

Loading Controls

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VetSignal

GeneTex is proud to launch its new VetSignal™ line of products to advance veterinary science research. These antibodies and other Read More...

Zebrafish

As the leading manufacturer of zebrafish antibodies, GeneTex offers an extensive portfolio of reagents validated for use in this model Read More...

Infectious Diseases

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Signaling Pathways

Cell signaling refers to the various sequences of molecular events that mark a cell’s response to its environment, whether that Read More...

Cell Markers

Cell markers are biochemical or genetic characteristics that distinguish and discriminate between different cell types. Although most are molecules expressed Read More...

Cardiovascular

The cardiovascular system is composed of the heart and circulatory system. It is responsible for delivery of oxygen- and nutrient-rich Read More...

Epigenetics

Epigenetics is the study of heritable phenotype changes that affect gene activity and expression that do not involve alterations in Read More...

Neuroscience

Neuroscience research has become a major focus for countries all over the world. The United States, European nations, Japan, China, Read More...

Tumor Markers

A tumor marker is a substance produced, or induced, by cancer cells that can be detected in body fluids or Read More...

Cancer

Oncoproteins The products of metazoan cell proto-oncogenes are generally key constituents of the cell signaling and gene expression machinery that Read More...

Necrosis

What is necrosis Necrosis is an acute and severe response leading to the premature death of cells consequently damaging nearby Read More...

Metabolism

Metabolism is the set of chemical reactions involved in maintaining the living state of cells and the organism. These chemical Read More...

Cell Biology

Cell biology is the study of cell structure and function. This includes the most general properties shared by all cells Read More...

GeneTex webinar: Pancreatic Cancer

Pancreatic Cancer - An Insidious and Stubborn Foe Date and time: 3 p.m. - 4 p.m. 17th September (CEST) Presenter: Read More...

Pathway Posters

Genetex Pathway Posters

Download GeneTex pathway posters to help your research and education. Cancer SignalingNeural MarkersCardiovascularMitochondriaHypoxia RegulationDNA Damage & RepairNeurodegenerative DisordersImmune ResponseBiological ResearchOrganelle Read More...

Monoclonal Antibodies

At Stratech, we specialise in providing a comprehensive range of monoclonal antibodies (mAbs) for scientific research. We partner with state-of-the-art Read More...

Autophagy

What is Autophagy? Autophagy (namely self-eating) is a highly conserved process for disassembling intracellular excess and dysfunctional components such as Read More...