EpiCypher offers cutting edge tools and service for epigenetics and chromatin biology research. We pioneered the manufacture of designer recombinant nucleosomes that contain defined post-translational modifications. Our latest product, SNAP-ChIP, is the gold standard for antibody validation for chromatin IP, and also serves as the most reproducible spike-in for normalizing ChIP and ChIP-seq assays. EpiCypher also develops assays for chromatin-modifying enzymes and PTM-binding proteins using a variety of readouts, such as Alpha, FRET and radioactivity, employing nucleosome or peptide-based substrates.
Recombinant Nucleosomes (Complete List)
SNAP-ChIP™ spike-ins
Modified Designer Nucleosomes (dNucs™)
dCypher™ Nucleosome Panels
EpiDyne™ Chromatin Remodeling Substrates
Recombinant Nucleosomes (rNucs)
Purified Nucleosomes (HeLa, Avian)
Nucleosome Components and Subunits
Variant Nucleosomes (vNucs)
Oncogenic Nucleosomes (oncoNucs)
Methyl DNA Designer Nucleosomes
EpiCypher is dedicated to creating novel platforms that support innovative chromatin research. We are constantly expanding our product lines to provide the latest in quantitative chromatin technology.
New CUTANA CUNT&RUN
Compatible Antibodies
Extensively validated. Meticulously optimized.
NEW! CUTANA™
ChIC / CUT&RUN Kit
Extensively validated. Meticulously optimized.
Ultra-sensitive genomic profiling assays with lower input and sequencing read depth requirements than ChIP
Accurate ChIP-seq antibody validation and data normalization using DNA-barcoded nucleosome spike-ins
Robust, high-resolution chromatin profiling, at a fraction of the time and cost of ChIP-seq
Name | Cat. No. |
Mononucleosomes, biotinylated | 16-0006 |
Mononucleosomes, non-biotinylated | 16-0009 |
Mononucleosomes, desthiobiotinylated | 16-0024 |
Tailless Nucleosomes, biotinylated | 16-0027 |
Mononucleosomes, H3.1 ΔN2, biotinylated | 16-0023 |
Mononucleosomes, H3.1 ΔN32, biotinylated | 16-0016 |
Mononucleosomes, H3.1 ΔN32, non-biotinylated | 16-1016 |
Mononucleosomes, H3.3 ΔN32, biotinylated | 16-0017 |
Mononucleosomes, H3.3 ΔN32, non-biotinylated | 16-0017 |
Mononucleosomes, H4 ΔN15, biotinylated | 16-0018 |
Lysine Methylation
Name | Cat# | Name | Cat# |
H3K4me1, biotinylated | 16-0321 | H3K36me1, biotinylated | 16-0322 |
H3K4me2, biotinylated | 16-0334 | H3K36me2, biotinylated | 16-0319 |
H3K4me2, non-biotinylated | 16-1334 | H3K36me2, non-biotinylated | 16-1319 |
H3K4me3, biotinylated | 16-0316 | H3K36me3, biotinylated | 16-0320 |
H3K4me3, non-biotinylated | 16-1316 | H3K36me3, non-biotinylated | 16-1320 |
H3K4me3,K9,14,18ac | 16-0335 | H3.3K36me3, biotinylated | 16-0390 |
H3K9me1, biotinylated | 16-0325 | H3K79me1, biotinylated | 16-0367 |
H3K9me2, biotinylated | 16-0324 | H3K79me2, biotinylated | 16-0368 |
H3K9me3, biotinylated | 16-0315 | H3K79me3, biotinylated | 16-0369 |
H3K27me1, biotinylated | 16-0338 | H4K12me1, biotinylated | 16-0393 |
H3K27me2, biotinylated | 16-0339 | H4K20me1, biotinylated | 16-0331 |
H3K27me3, biotinylated | 16-0317 | H4K20me2, biotinylated | 16-0332 |
H3K27me3, non-biotinylated | 16-1317 | H4K20me3, biotinylated | 16-0333 |
H4K20me3, non-biotinylated | 16-1333 |
Lysine Acylation
Name | Cat# | Name | Cat# |
H2AK5,9,13,15ac, biotinylated | 16-0376 | H3K27bu, biotinylated | 16-0384 |
H2BK12ac, biotinylated | 16-0386 | H3K27cr, biotinylated | 16-0383 |
H2BK20ac, biotinylated | 16-0387 | H3K27ac, S28phos, biotinylated | 16-0385 |
H3K4ac, biotinylated | 16-0342 | H3K36ac, biotinylated | 16-0378 |
H3K9ac, biotinylated | 16-0314 | H4K5ac, biotinylated | 16-0352 |
H3K9ac, non-biotinylated | 16-1314 | H4K8ac, biotinylated | 16-0353 |
H3K9bu, biotinylated | 16-0371 | H4K12ac, biotinylated | 16-0312 |
H3K9cr, biotinylated | 16-0351 | H4K16ac, biotinylated | 16-0354 |
H3K14ac, biotinylated | 16-0343 | H4K20ac, biotinylated | 16-0377 |
H3K18ac, biotinylated | 16-0372 | H2AK5,9,13,15ac, biotinylated | 16-0376 |
H3K18bu, biotinylated | 16-0373 | H3K4,9,14,18ac, biotinylated | 16-0336 |
H3K18cr, biotinylated | 16-0337 | H3K4me3, K9,14,18ac, biotinylated | 16-0335 |
H3K23ac, biotinylated | 16-0364 | H4K5,8,12,16ac, biotinylated | 16-0313 |
H3K27ac, biotinylated | 16-0365 | H4K5,8,12,16ac, non-biotinylated | 16-1313 |
H3K27ac, non-biotinylated | 16-1365 | H3K4,9,14,18ac / H4K5,8,12,16ac, biotinylated | 16-0374 |
H3K27acS28phos, biotinylated | 16-0385 |
Arginine Methylation
Name | Cat# | Name | Cat# |
H2AR3me1, biotinylated | 16-0359 | H3R8me2a, biotinylated | 16-0380 |
H2AR3me2a, biotinylated | 16-0360 | H3R8me2s, biotinylated | 16-0381 |
H2AR3me2s, biotinylated | 16-0361 | H3R17me1, biotinylated | 16-0382 |
H3R2me1, biotinylated | 16-0340 | H3R17me2a, biotinylated | 16-0375 |
H3R2me2a, biotinylated | 16-0341 | H4R3me1, biotinylated | 16-0356 |
H3R2me2s, biotinylated | 16-0355 | H4R3me2a, biotinylated | 16-0357 |
H3R8me1, biotinylated | 16-0379 | H4R3me2s, biotinylated | 16-0358 |
Lysine Ubiquitination
Name | Cat# | Name | Cat# |
H2AUb1, biotinylated | 16-0020 | H2BK120ub, biotinylated | 16-0370 |
H2AK119ub, biotinylated | 16-0363 | H3K14ub, biotinylated | 16-0391 |
H2AK129ub, biotinylated | 16-0394 |
Other PTMs
Name | Cat# | Name | Cat# |
H3R2,8,17cit, biotinylated | 16-0362 | H3S10phos, non-biotinylated | 16-1345 |
H3R2,8,17cit, non-biotinylated | 16-1362 | H3.1S28phos, biotinylated | 16-0388 |
H3S10phos, biotinylated | 16-0345 | H3.3S31phos, biotinylated | 16-0389 |
Small Pack Sizes Available
Name | Cat# | Name | Cat# |
H3K4me1, biotinylated | 16-0321 | H3K9me3, biotinylated | 16-0315 |
H3K4me2, biotinylated | 16-0334 | H3K27ac, biotinylated | 16-0365 |
H3K4me2, non-biotinylated | 16-1334 | H3K27me3, biotinylated | 16-0317 |
H3K9ac, biotinylated | 16-0314 | H3K36me2, biotinylated | 16-0319 |
H3K9me2, biotinylated | 16-0324 | H3K36me3, biotinylated | 16-0320 |
Name | Cat# |
H2AX | 16-0013 |
H2AX, non-biotinylated | 16-1013 |
H2AXS139phos | 16-0366 |
H2AZ.1 | 16-0014 |
H2AZ.1, non-biotinylated | 16-1014 |
H2AZ.2 | 16-0015 |
H3.3 | 16-0011 |
H3.3, non-biotinylated 100 μg | 16-0012 |
Name | Cat# |
Mononucleosomes, Hemi-methylated, Biotinylated | 16-2003 |
Mononucleosomes, Hemi-methylated | 16-2103 |
Mononucleosomes, 187×601 DNA, Biotinylated | 16-2004 |
Mononucleosomes, 187×601 DNA | 16-2104 |
Name | Cat# |
SNAP-ChIP K-MetStat Panel | 19-1001 |
SNAP-ChIP OncoStat Panel | 19-2001 |
SNAP-ChIP K-AcylStat Panel | 19-3001 |
Name | Cat# |
H3.3K4M | 16-0349 |
H3.3K9M | 16-0350 |
H3.3K27M | 16-1323 |
H3.3K27M, non-biotinylated | 16-0323 |
H3.3G34R | 16-0346 |
H3.3G34V | 16-0347 |
H3.3G34W | 16-0348 |
H3.3K36M | 16-0344 |
Name | Cat# |
EpiDyne FRET Nucleosome Remodeling Assay Substrate | 16-4201 |
EpiDyne Nucleosome Remodeling Assay Substrate ST601-GATC1 | 16-4101 |
EpiDyne Remodeling Assay Substrate DNA ST601-GATC0 | 18-4100 |
EpiDyne Remodeling Assay Substrate DNA ST601-GATC1 | 18-4101 |
Name | Cat# |
dCypher™ Nucleosome Full Panel | 16-9001 |
dCypher™ Nucleosome K-MetStat & OncoStat Panel | 16-9002 |
dCypher™ Nucleosome K-AcylStat Panel | 16-9003 |
dCypher™ Nucleosome R-MetStat Panel | 16-9004 |
SNAP-ChIP™ spike-in panels use modified DNA-barcoded Designer Nucleosomes (dNucs™) carrying disease-relevant histone PTMs as quantitative controls and for antibody validation, enabling unprecedented control of ChIP experiments.
Three ways SNAP-ChIP spike-ins improve ChIP
Name | Cat# |
SNAP-ChIP™ K-MetStat Panel | SKU: 19-1001 |
SNAP-ChIP™ K-AcylStat Panel | SKU: 19-3001 |
SNAP-ChIP™ OncoStat Panel | SKU: 19-2001 |
Histone H3K4me3 Antibody: SNAP-ChIP™ Certified, CUTANA™ CUT&RUN Compatible | SKU: 13-0041 |
Histone H3K27me3 Antibody, SNAP-ChIP™ Certified, CUTANA™ CUT&RUN Compatible | SKU: 13-0030 |
SNAP-ChIP™ Dual Labeled Hydrolysis Probe | SKU: 18-6001 |
SNAP-ChIP™ K-MetStat™ Full Panel Primer Set | SKU: 18-6101 |
SNAP-ChIP™ OncoStat™ Panel Primer Set | SKU: 18-6201 |
SNAP-ChIP™ K-MetStat™ H3K4 MiniPanel Primer Set | SKU: 18-6102 |
SNAP-ChIP™ K-MetStat™ H3K9 MiniPanel Primer Set | SKU: 18-6103 |
SNAP-ChIP™ K-MetStat™ H3K27 MiniPanel Primer Set | SKU: 18-6104 |
SNAP-ChIP™ K-MetStat™ H3K36 MiniPanel Primer Set | SKU: 18-6105 |
SNAP-ChIP™ K-MetStat™ H4K20 MiniPanel Primer Set | SKU: 18-6106 |
EpiCypher dNucs™ are semi-synthetic recombinant nucleosomes, containing one (or more) histone PTMs. Nucleosomes are the natural target of chromatin readers and modifying enzymes, and thus provide a superior substrate for epigenetic enzymes and interactor proteins
dNuc substrates enable cutting-edge chromatin research
EpiCypher has an extensive library of >70 uniquely modified dNucs, useful for:
dCypher™ Nucleosome Panels provide unprecedented access to epigenetic diversity in a physiologically relevant nucleosome context. Each panels contain single and combinatorially-modified nucleosomes, and can be purchased as focused sets (Lysine Acylation, Arginine Methylation and the Lysine-Methylation / Oncostat panels) or as one large panel (Full Nucleosome Panel).
Three ways to leverage dCypher Nucleosome Panel diversity
Chromatin remodeling has been implicated in diverse diseases, including most types of cancer. The study of chromatin remodeling requires highly defined nucleosomal substrates, which are challenging to produce and adapt to various assays. The EpiDyne™ platform addresses this unmet need, leveraging EpiCypher dNucs™ as substrates for a variety of nucleosome remodeling assays.
EpiDyne substrates are available for three assay readouts
Name | Cat# |
Mononucleosomes, (H3.1ΔN32), Recombinant, 187×601 DNA | SKU: 16-2134 |
Mononucleosomes, Recombinant Human, Desthiobiotinylated | SKU: 16-0024 |
Tailless Nucleosomes, Recombinant Human, Biotinylated | SKU: 16-0027 |
Mononucleosomes, Recombinant Human | SKU: 16-0009 |
Mononucleosomes, Recombinant Human Biotinylated | SKU: 16-0006 |
Mononucleosomes, Recombinant, Hemi-methylated, Biotinylated | SKU: 16-2003 |
Mononucleosomes, Recombinant, Hemi-methylated | SKU: 16-2103 |
Mononucleosomes (H2AX), Human Recombinant | SKU: 16-1013 |
Mononucleosomes (H2AX), Human Recombinant Biotinylated | SKU: 16-0013 |
Mononucleosomes (H2AZ.1), Human Recombinant | SKU: 16-1014 |
Mononucleosomes (H2AZ.1), Human Recombinant Biotinylated | SKU: 16-0014 |
Mononucleosomes (H2AZ.2), Human Recombinant Biotinylated | SKU: 16-0015 |
Mononucleosomes (H3.3), Human Recombinant Biotinylated | SKU: 16-0011 |
Mononucleosomes (H3.3), Human Recombinant | SKU: 16-0012 |
Mononucleosomes (H3.1 N32), Recombinant Human | SKU: 16-1016 |
Mononucleosomes (H3.1 ΔN32), Recombinant Human Biotinylated | SKU: 16-0016 |
Mononucleosomes (H3.3 N32), Recombinant Human Biotinylated | SKU: 16-0017 |
Mononucleosomes (H3.3 ΔN32), Recombinant Human | SKU: 16-1017 |
Name | Cat# |
HeLa Mononucleosomes, Purified | SKU: 16-0002 |
HeLa Polynucleosomes, Purified | SKU: 16-0003 |
Chicken Mononucleosomes, Purified | SKU: 16-0019 |
Chicken Polynucleosomes, Purified | SKU: 16-0004 |
Chicken Polynucleosomes, Purified (HSW) | SKU: 16-0022 |
Name | Cat# |
Histone Octamer (H3.1 ΔN32), Recombinant Human | SKU: 16-8016 |
Histone Octamer (H4 ΔN15), Recombinant Human | SKU: 16-8018 |
Histone Octamer (H3.3), Human Recombinant | SKU: 16-8012 |
Histone Octamer, Recombinant Human | SKU: 16-0001 |
Nucleosome Assembly 601 Sequence DNA, Biotinylated | SKU: 18-0005 |
EpiDyne Remodeling Assay Substrate DNA ST601-GATC0 | SKU: 18-4100 |
EpiDyne Remodeling Assay Substrate DNA ST601-GATC1 | SKU: 18-4101 |
SNAP-ChIP™ Dual Labeled Hydrolysis Probe | SKU: 18-6001 |
SNAP-ChIP™ K-MetStat™ Full Panel Primer Set | SKU: 18-6101 |
SNAP-ChIP™ OncoStat™ Panel Primer Set | SKU: 18-6201 |
SNAP-ChIP™ K-MetStat™ H3K4 MiniPanel Primer Set | SKU: 18-6102 |
SNAP-ChIP™ K-MetStat™ H3K9 MiniPanel Primer Set | SKU: 18-6103 |
SNAP-ChIP™ K-MetStat™ H3K27 MiniPanel Primer Set | SKU: 18-6104 |
SNAP-ChIP™ K-MetStat™ H3K36 MiniPanel Primer Set | SKU: 18-6105 |
SNAP-ChIP™ K-MetStat™ H4K20 MiniPanel Primer Set | SKU: 18-6106 |
Histone H2A/H2B Dimer, Recombinant Human | SKU: 15-0311 |
Histone H3/H4 Tetramer, Recombinant Human | SKU: 16-0008 |
Name | Cat# |
Mononucleosome (H3.1ΔN2), Recombinant Human, Biotinylated | SKU: 16-0023 |
Mononucleosomes (H2AX), Human Recombinant | SKU: 16-1013 |
Mononucleosomes (H2AX), Human Recombinant Biotinylated | SKU: 16-0013 |
Mononucleosomes (H2AZ.1), Human Recombinant | SKU: 16-1014 |
Mononucleosomes (H2AZ.1), Human Recombinant Biotinylated | SKU: 16-0014 |
Mononucleosomes (H2AZ.2), Human Recombinant Biotinylated | SKU: 16-0015 |
Mononucleosomes (H3.3), Human Recombinant Biotinylated | SKU: 16-0011 |
Mononucleosomes (H3.3), Human Recombinant | SKU: 16-0012 |
Somatic mutations in histone proteins occur in diverse cancer types, but have been challenging to study in a physiological context. EpiCypher’s oncogenic nucleosomes (oncoNucs) are assembled with histones containing mutations specifically associated with cancer, thus providing highly relevant nucleosomal substrates for cancer research.
Advancing cancer research with oncoNucs
Name | Cat# |
Mononucleosomes (H3.3G34R), Recombinant Human, Biotinylated | SKU: 16-0346 |
Mononucleosomes (H3.3K4M), Recombinant Human Biotinylated | SKU: 16-0349 |
Mononucleosomes (H3.3K9M), Recombinant Human Biotinylated | SKU: 16-0350 |
Mononucleosomes (H3.3 K27M), Recombinant Human | SKU: 16-0323 |
Mononucleosomes (H3.3 K27M), Recombinant Human Biotinylated | SKU: 16-1323 |
Mononucleosomes (H3.3G34V), Recombinant Human Biotinylated | SKU: 16-0347 |
Mononucleosomes (H3.3G34W), Recombinant Human Biotinylated | SKU: 16-0348 |
Mononucleosomes (H3.3K36M), Recombinant Human Biotinylated | SKU: 16-0344 |
DNA methylation is one of the most well-studied epigenetic modifications, and has known roles in regulating gene expression and genomic stability. EpiCypher methyl DNA designer nucleosomes (MeDNA dNucs) are unmodified nucleosomes wrapped with unmethylated or hemi-methylated DNA, and are the optimal substrates for interrogating the function of DNA methylation on the binding activity of chromatin-associated proteins or inhibitors.
Three ways to use MeDNA dNucs to explore chromatin function
Name | Cat# |
Mononucleosomes, Recombinant, 187×601 DNA | SKU: 16-2104 |
Mononucleosomes, Recombinant, 187×601 DNA, Biotinylated | SKU: 16-2004 |
Mononucleosomes, Recombinant, Hemi-methylated, Biotinylated | SKU: 16-2003 |
Mononucleosomes, Recombinant, Hemi-methylated | SKU: 16-2103 |
Nucleosome Assembly 601 Sequence, 187bp, Biotinylated | SKU: 18-2004 |
Nucleosome Assembly 601 Sequence, 187bp, Hemi-methylated, Biotinylated | SKU: 18-2003 |
CUT&RUN provides high-resolution chromatin profiling with low cell input and sequencing requirements. CUTANA™ CUT&RUN Compatible Antibodies have been rigorously tested for reliable and robust performance in CUT&RUN assays. Each antibody passes our stringent SNAP-ChIP™ certification criteria, and sequencing results between ChIP-seq and CUT&RUN are highly correlated.
Which antibodies work in CUT&RUN? Let EpiCypher do the work for you!
EpiCypher offers a wide range of antibodies to help study lysine methylation, especially with regards to histone post-translational modifications (PTMs). Many of these are EpiCypher SNAP-ChIP™ Certified Antibodies, which have been extensively validated using SNAP-ChIP spike-in technology, delivering histone methylation-specific antibodies with the highest specificity and IP efficiency on the market.
Antibodies are a key reagent for chromatin research
Our antibodies can be used for:
Name | Cat# |
Histone H3 K4Me3 Antibody | SKU: 13-0004 |
Histone H3K4me3 Antibody: SNAP-ChIP® Certified, CUTANA™ CUT&RUN Compatible | SKU: 13-0041 |
Histone H3 K9Me1 Antibody | SKU: 13-0014 |
Histone H3K4me2 Antibody, SNAP-ChIP Certified (monoclonal) | SKU: 13-0027 |
Histone H3K4me3 Antibody, SNAP-ChIP Certified | SKU: 13-0028 |
Histone H3K9me1 Antibody, SNAP-ChIP Certified | SKU: 13-0029 |
Histone H3K27me3 Antibody, SNAP-ChIP™ Certified, CUTANA™ CUT&RUN Compatible | SKU: 13-0030 |
Histone H3K36me3 Antibody, SNAP-ChIP™ Certified, CUTANA™ CUT&RUN Compatible | SKU: 13-0031 |
SETD2 Antibody | SKU: 13-0025 |
SETD6 Antibody | SKU: 13-0003 |
EpiCypher offers a wide range of antibodies to help study arginine methylation, including those specific for the enzymes that catalyze the modifications.
Antibodies are a key reagent for chromatin research
Our antibodies can be used for:
Name | Cat# |
Asymmetric Dimethyl-arginine Antibody (ADMA) Asym26 | SKU: 13-0011 |
CARM1 / PRMT4 Antibody | SKU: 13-0006 |
PRMT1 Antibody | SKU: 13-0007 |
PRMT5 / JBP1 Antibody | SKU: 13-0008 |
PRMT7 Antibody | SKU: 13-0009 |
Symmetric Dimethyl-arginine Antibody (SDMA) Sym10 | SKU: 13-0012 |
Histone H3 R8Me1 Antibody | SKU: 13-0017 |
Histone H3 R8Me2a Antibody | SKU: 13-0018 |
Histone H3 R8Me2s Antibody | SKU: 13-0019 |
Histone H3 R17Me2a Antibody | SKU: 13-0016 |
GST Epitope Tag Antibody
SKU: 13-0022
Pack Size: 100 μg
Type: Polyclonal
Host: Rabbit
Mol Wgt.: N/A
Appl.: IF, WB
Format: Serum
Reactivity: N/A
GST Epitope Tag Antibody Description:
Glutathione S-transferase (GST) is a 26 kDa protein from Schistosoma japonica and is used as an epitope tag for improving the expression and solubility of GST fusion proteins expressed in E coli. This antibody is useful for detection of GST-tagged proteins on the EpiTitan Histone Peptide array and for detection of GST-tagged fusion proteins by Western Blot, including proteins bound to specific peptides in pull-down experiments.
Antibodies specific for a variety of enzymes that modify histones.
Name | Cat# |
CARM1 / PRMT4 Antibody | SKU: 13-0006 |
PRMT1 Antibody | SKU: 13-0007 |
PRMT5 / JBP1 Antibody | SKU: 13-0008 |
PRMT7 Antibody | SKU: 13-0009 |
SETD2 Antibody | SKU: 13-0025 |
EpiCypher offers a wide range of anti-nucleosome antibodies for various chromatin assays, targeting specific histone post-translational modifications, such as arginine methylation, and unmodified histones. In addition, our SNAP-ChIP™ Certified Antibodies have been extensively validated for ChIP experiments, using recombinant modified designer nucleosomes (dNucs) for in-application testing in a nucleosome context.
Antibodies are a key reagent for chromatin research
Our antibodies can be applied for:
Name | Cat# |
CUTANA ChIC/CUT&RUN Kit | 14-1048-EPC |
CUTANA™ CUT&RUN 8-strip 0.2mL tubes | 10-0009-EPC |
CUTANA™ E. coli Spike-in DNA | 18-1401-EPC |
CUTANA™ pAG-MNase for ChIC/CUT&RUN Workflows - 50 rxns | 15-1016-EPC |
CUTANA™ Rabbit IgG CUT&RUN Negative Control Antibody | 13-0042-EPC |
Magnetic Separation Rack, 1.5 mL Tubes | 10-0012-EPC |
CUTANA™ pAG-MNase for ChIC/CUT&RUN Workflows - 250 Rxns | 15-1116-EPC |
Magnetic Separation Rack, 0.2 mL Tubes | 10-0008-EPC |
CUTANA™ Concanavalin A Conjugated Paramagnetic Beads | 21-1401-EPC |
Histone H3K4me3 Antibody: SNAP-ChIP™ Certified, CUTANA™ CUT&RUN Compatible | 13-0041-EPC |
Histone H3K27me3 Antibody, SNAP-ChIP™ Certified, CUTANA™ CUT&RUN Compatible | 13-0030-EPC |
Histone H3K36me3 Antibody, SNAP-ChIP™ Certified, CUTANA™ CUT&RUN Compatible | 13-0031-EPC |
CUTANA™ CUT&Tag reagents, kits, and assay services enable rapid, cost-effective epigenomic mapping and deliver high quality data with improved resolution compared to ChIP-seq.
Try CUTANA CUT&Tag assays for next-generation epigenomic profiling
Name | Cat# |
CUTANA™ pAG-Tn5 for ChIC/CUT&Tag - 50 rxns | SKU: 15-1017 |
CUTANA™ pAG-Tn5 for ChIC/CUT&Tag - 250 Rxns | SKU: 15-1117 |
CUTANA™ Concanavalin A Conjugated Paramagnetic Beads | SKU: 21-1401 |
Histone H3K4me3 Antibody: SNAP-ChIP™ Certified, CUTANA™ CUT&RUN Compatible | SKU: 13-0041 |
CUTANA™ Rabbit IgG CUT&RUN Negative Control Antibody | SKU: 13-0042 |
Magnetic Separation Rack, 0.2 mL Tubes | SKU: 10-0008 |
Magnetic Separation Rack, 1.5 mL Tubes | SKU: 10-0012 |
CUTANA™ CUT&RUN 8-strip 0.2mL tubes | SKU: 10-0009 |
CUTANA™ High Fidelity 2X PCR Master Mix | SKU: 15-1018 |
Histone H3K27me3 Antibody, SNAP-ChIP™ Certified, CUTANA™ CUT&RUN Compatible | SKU: 13-0030 |
Nuclear extracts can be a rich source of chromatin-associated proteins, including transcription factors, chromatin modifying enzymes, and regulatory complexes, and are commonly used as controls or to profile binding interactions of novel proteins. EpiCypher offers high-quality HeLa cell nuclear extracts for these diverse chromatin applications.
Three ways to apply HeLa Nuclear Extracts
EpiCypher offers mammalian vectors encoding wild-type histone H3.3, as well as the oncogenic H3.3K9M and H3.3K27M. These histones can be used to screen binders or inhibitors that are sensitive to common histone mutations.
ATP-dependent chromatin remodeling enzymes are among the most commonly mutated proteins in cancer, making them a top target for the development of novel therapeutic strategies. The EpiDyne™ platform leverages EpiCypher dNucs as substrates to study nucleosome remodeling. To complement these assays, EpiCypher offers a range of remodeling enzymes, including SMARCA2 and SMARCA4 (the ATPases of the SWI/SNF complex) and the ACF ISWI-type complex.
EpiDyne : advanced tools for next-generation epigenetics assays
EpiDyne Chromatin Remodeling Enzymes can be used in a variety of assay readouts, including:
Name | Cat# |
SMARCA2 Chromatin Remodeling Enzyme (Human BRM) | SKU: 15-1015 |
SMARCA4 Chromatin Remodeling Enzyme (Human BRG1) | SKU: 15-1014 |
ACF Chromatin Remodeling Enzyme Complex | SKU: 15-1013 |
Recombinant histone proteins are the building block of nucleosomes, and an essential reagent in chromatin research. EpiCypher offers highly pure recombinant histone proteins, including canonical histones (H2A, H2B, H3 and H4) and histone variants, such as H2AZ.1, H2AZ.2 and H2AX.
Application of EpiCypher Recombinant Histones
Chromatin modifying enzymes target specific histone residues for post-translational modification, including methylation, acetylation, phosphorylation. As such, these proteins drive major changes in chromatin structure, and are important targets in academic and pharmaceutical research. EpiCypher offers a library of histone methyltransferase enzymes and catalytic domains, each highly pure and validated for on-target substrates.
Applications for chromatin modifying enzymes
Name | Cat# |
SMARCA2 Chromatin Remodeling Enzyme (Human BRM) | SKU: 15-1015 |
SMARCA4 Chromatin Remodeling Enzyme (Human BRG1) | SKU: 15-1014 |
ACF Chromatin Remodeling Enzyme Complex | SKU: 15-1013 |
5x ACF Remodeling Assay Buffer | SKU: 21-0013 |
DOT1L Catalytic Domain, Recombinant Human | SKU: 15-1001 |
G9a, Recombinant Human, His-tagged | SKU: 15-1010 |
NSD2 / MMSET Catalytic Domain, Recombinant Human | SKU: 15-1002 |
SETD2, Recombinant Human | SKU: 15-1012 |
SETD2, Recombinant Human GST-tagged | SKU: 15-1011 |
SETD6, Recombinant Human | SKU: 15-1004 |
SMYD2, Recombinant Human | SKU: 15-1006 |
SMYD3, Recombinant Human | SKU: 15-1007 |
EpiCypher histone peptide arrays enable rapid, high-throughput screening of chromatin effector proteins, antibodies, and enzymes against a diverse repertoire of single and combinatorial histone PTMs. We offer two versions of histone peptide arrays : the EpiTitan™ array (95 unique modifications) and the EpiTriton™ array (296 unique modifications). Extensive validation and purification of peptides is performed prior to histone peptide array printing to ensure the highest quality product for your studies.
Advantages of EpiCypher Histone Peptide Arrays
Name | Cat# |
NEW EpiTriton™ Histone Peptide Array | SKU: 11-4001 |
EpiCypher modified histone peptides are highly pure and extensively validated, ensuring the highest quality product for chromatin research. Our modified H2A peptides are biotinylated, allowing use in peptide pull down and / or binding assays.
Advantages of EpiCypher Histone Peptides
Name | Cat# |
Histone H2B N-terminal Peptide, Biotinylated | SKU: 12-0077 |
Histone H2BK12, K15, K16, K20ac Peptide, Biotinylated | SKU: 12-0211 |
Histone H2BK12ac Peptide, Biotinylated | SKU: 12-0207 |
Histone H2BK15ac Peptide, Biotinylated | SKU: 12-0208 |
Histone H2BK16ac Peptide, Biotinylated | SKU: 12-0209 |
Histone H2BK20ac Peptide, Biotinylated | SKU: 12-0210 |
Histone H2BK5me1 Peptide, Biotinylated | SKU: 12-0206 |
Histone H2BK5me2 Peptide, Biotinylated | SKU: 12-0205 |
Histone H2BK5me3 Peptide, Biotinylated | SKU: 12-0204 |
EpiCypher modified histone peptides are highly pure and extensively validated, ensuring the highest quality product for chromatin research. Our modified H3 peptides are biotinylated, allowing use in peptide pull down and / or binding assays.
Advantages of EpiCypher Histone Peptides
EpiCypher modified histone peptides are highly pure and extensively validated, ensuring the highest quality product for chromatin research. Our modified H4 peptides are biotinylated, allowing use in peptide pull down and / or binding assays.
Advantages of EpiCypher Histone Peptides