EpiCypher offers cutting edge tools and service for epigenetics and chromatin biology research. We pioneered the manufacture of designer recombinant nucleosomes that contain defined post-translational modifications. Our latest product, SNAP-ChIP, is the gold standard for antibody validation for chromatin IP, and also serves as the most reproducible spike-in for normalizing ChIP and ChIP-seq assays. EpiCypher also develops assays for chromatin-modifying enzymes and PTM-binding proteins using a variety of readouts, such as Alpha, FRET and radioactivity, employing nucleosome or peptide-based substrates.

Product Categories

Recombinant Nucleosomes
SNAP-ChIP® spike-ins
dCypher® Nucleosome Panels
EpiDyne® Chromatin Remodeling Substrates
Modified Designer Nucleosomes (dNucs™)
Recombinant Nucleosomes (rNucs)
Oncogenic Nucleosomes (oncoNucs)
Variant Nucleosomes (vNucs)
Methyl DNA Designer Nucleosomes
Purified Nucleosomes (HeLa, Avian)
Nucleosome Components and Subunits

Epigenetics Reagents & Assays
SNAP-ChIP Certified Antibodies
PTM specific Antibodies
Cell Extracts
Histone Expression Vector

Recombinant Proteins
EpiDyne® Chromatin Remodeling Enzymes
Recombinant Histones
Histone Binding Domains
Modifying Enzymes

Histone Peptides & Arrays
Histone Peptide Arrays
H2A Peptides
H2B Peptides
H3 Peptides
H4 Peptides

dCypher® Nucleosome Panels: Unparalleled Diversity for Rapid Histone PTM Profiling

Epigenetics is one of the fastest-growing areas of academic and pharmaceutical research, with many projects focused on understanding the functions Read More...

SNAP-ChIP® Spike-In Controls are Essential for ChIP Experiments

Despite the overwhelming popularity of chromatin immunoprecipitation (ChIP) in epigenetics research, ChIP methods have poor yields, high background, and low Read More...

Exploring Chromatin Remodeling Substrates with Nucleosomes

Nucleosomes are the fundamental repeating units of chromatin, comprised of a histone octamer wrapped by ~147bp DNA. A common focus Read More...

Peptide or Nucleosome?

dCypher ™ Reveals the Optimal Substrate for Histone PTM Analyses Histone ‘reader’ proteins contain evolutionarily conserved domains that bind to Read More...

Designer nucleosomes important for epigenetics research

Nucleosome substrates are emerging tools for the in vitro study of chromatin epigenetic regulation, with applications from basic chromatin biology Read More...