Antibodies

Biosimilars are biological products such as proteins and antibodies that are highly analogous to FDA‐approved biologic reference products and have no clinically meaningful differences in terms of safety and effectiveness from reference products. Biosimilar monoclonal antibodies are an important part of the biosimilar family that can be used in the treatment of diseases like cancer and autoimmune disorders and is also important for research use.

Abeomics provides an array of biosimilar recombinant monoclonal antibodies that include Recombinant anti-human ErbB2/HER2 Antibody (Trastuzumab), Anti-Human CD11a (Efalizumab), Anti-Human CD194 (CCR4) (Mogamulizumab) and many more.

Toll-like receptors (TLRs) belong to a class of pattern recognition receptors (PRRs) that constitute the first line of defense system against pathogenic microbes. TLRs recognize both the external pathogen-associated molecular patterns (PAMPs) derived from various microbes and endogenous self-derived molecules from damaged cells, damage-associated molecular patterns (DAMPs). TLRs play a crucial role in innate immunity by initiating signal transduction pathways, leading to activation of the transcription factors NF-kB and IRFs and expression of cytokines, chemokines, and type I IFNs genes. TLRs comprise a family of type I transmembrane receptors that contain three structural domains: an extracellular LRR (Leucine-Rich Repeat) domain, a transmembrane domain and an intracellular Toll/IL-1 receptor (TIR) domain. TLRs are expressed in both innate immune cells like macrophages and dendritic cells, and in non-immune cells including fibroblast cells and epithelial cells. In humans, 10 TLRs have been identified (TLR1–TLR10) in comparison to mouse where 13 TLRs (TLR1–TLR13) have been identified till now.

Abeomics have developed several TLR antibodies including antibodies to TLR6, TLR9, TLR3, TLR4, TLR8, TLR5, and other proteins of TLR pathways.

Apoptosis is the process by which a cell stops dividing and growing and instead begins a process that eventually leads to the cell’s controlled death without releasing its contents into the surrounding environment. Together with several enzyme-dependent biochemical processes, apoptosis is characterised by variety of distinctive morphological changes in the cell’s structure. Apoptosis is a potentially complex process with several signalling pathways. With apoptosis at the forefront of study, scientists are able to create promising treatment approaches that centre on the voluntary death of abnormal cells. Monoclonal antibodies are desirable therapeutic possibilities due to their ability for disease-specific targeting and low toxicity profiles. By causing target cell-specific death or altering anti-apoptotic signalling pathways, monoclonal antibodies alone may make target cells more susceptible to chemotherapeutic or radiotherapeutic treatments, depending on their mode of action. Abeomics has developed cutting-edge technologies that have been used to build precision antibody such as DR4, NOXA, 14-3-3, TRAM, Caspase-3, Catalase, Caspase-1 etc.

Immunology is specifically the area of biology that deals with the immune system’s construction and operation, the physical separation of self and non-self, and the application of antibody-based laboratory methods or immunoassays. The two primary forms of defense are innate and adaptive immune responses, the latter of which is composed of cell-mediated and antibody-mediated responses. The innate immune system serves as the body’s initial line of defense against infection. It has some selectivity for microorganisms, activates the acute inflammatory response, and operates quickly but it has no memory. The adaptive immune system, in contrast, takes more time to mature, is extremely specialized, and retains the memory of earlier microbial encounters. Monoclonal antibodies can be used to identify surface molecules on a variety of immune cells and other tissues, which is crucial for the separation, characterization, and classification of immune cells as well as the investigation of the structure and function of diverse membrane surface molecules.

Abeomics offer several immunological antibodies that include both monoclonal and polyclonal antibodies like TIM-3, CD3, CD26, STING, NR2F6, RAGE, and many more.

DNA methylation is an epigenetic process that involves the addition of methyl groups to the DNA molecule at many different sites and alters the gene expression by producing lethal and mutagenic lesions. DNA methylation regulates gene expression by the recruitment of proteins involved in gene expression or inhibiting the transcription factors that bind to the DNA. Epigenetic mechanisms like DNA methylation are reversible processes and their inhibition plays a role in the repair of double-strand breaks, the most detrimental type of DNA damage. When damaged DNA is repaired, epigenetic markers are also reconstructed. DNA methylation is believed to be more resilient than other epigenetic markers and aids in maintaining alterations in gene expression. A DNA methylation antibody aids researchers in their understanding of DNA methylation and how illnesses, cell cycle control, and embryonic development are affected by it.

Abeomics Inc. offers well-characterized DNA methylation antibodies that may help scientists and researchers better understand the role of aberrant DNA methylation in diseases like cancer, atherosclerosis, cardiovascular diseases, and nervous disorders. Major methylation antibodies include DNMT3b, DNMT3a, MBD1, MLH1, PMS2 etc.

Capacities of a cell to receive, analyze, and send messages to its surroundings and within it are known as cell signaling. The cell reacts to various internal and external stimuli through cell signaling pathways. Cells have proteins called receptors that recognize chemical messages or physical stimuli initiating a physiological response that is essential for cell signaling. Transferring information from external stimuli to the cytoplasm, nucleus or other cellular organelles involves many components other than receptors forming cell signaling pathways. Diseases including diabetes, autoimmune illnesses, and cancer are brought on by errors in these cell signaling pathways that are brought on by mutations that can induce constitutive expression, activation, or inhibition of signaling proteins. Precision products for antibody cell signalling have been created using cutting-edge technology created by Abeomics. For your study, we provide a large selection of multi-application verified antibody cell signaling products some of them are Lck, ACE2, Chaperonin, ACP1, MYADM etc.

Infectious diseases are illnesses caused by harmful pathogens like bacteria, viruses, fungi, parasites, and animals and their toxic products through contaminated food, water, or other sources. Infectious diseases continue to harm human health, affecting every aspect of our lives. Infectious diseases are a leading cause of death in most parts of the world. Several vaccines and drugs like antibiotics (for bacterial diseases) have been developed to treat many infectious diseases. The necessity for developing innovative preventative and therapeutic approaches to treat these illnesses has been brought to light by the threat presented by emerging and reemerging infectious diseases. While there are numerous molecular antibody products under development for a range of infectious diseases, the use of antibody preparations to prevent infectious illnesses has a long history.

Abeomics offers a comprehensive selection of antibody solutions for several infectious diseases Like COVID-19, Ebola, MERS, and ZIKA to name a few. These antibodies are created utilizing advanced technologies and enable scientists and researchers to conduct research more efficiently.

Nuclear Factor-KappaB (NF-KappaB) is a heterodimeric protein made up of various combinations of Rel family transcription factor members. NF-KappaB is activated via the conventional and noncanonical (or alternative) signaling pathways, which, although having different signaling mechanisms, are both crucial for controlling immunological and inflammatory responses. NF-KappaB plays a crucial role in carcinogenesis and is a key regulator of cell fate choices, including the regulation of proliferation and programmed cell death. Toll-like receptors on innate immune system cells that recognize bacterial and viral products also induce NF-KappaB, which triggers the generation of proinflammatory cytokines and the activation of antigen-presenting cells for T-cell costimulation in the adaptive immunological response. Recent research has emphasized the significance of the link between NF-KappaB, inflammation, and cancer as well as the importance of treatments that control NF-KappaB activity.

Abeomics offers a wide variety of polyclonal and monoclonal antibodies, including TRF2, RANK, p50, RANKL, p65, NFKBIL1, and many more which help scientists and researchers conduct research more effectively.

Cancer is a group of disorders characterized by changes in the status and expression of several genes that provide somatic or germinal cells an advantage in survival and unrestricted capacity for cell division. Biochemical signs indicating the existence of cancer are known as cancer markers. Tumor indicators might be proteins, conjugated proteins, peptides, or carbohydrates depending on their chemical makeup. The majority of gene sequencing for medical diagnosis falls under the biomarker category. In clinical practice, it refers to a chemical that may be found in plasma and bodily fluids. Oncologists utilize a variety of cancer markers to assist identify the presence of cancer, each of which is suggestive of a unique disease phase. The body either develops these indicators in reaction to malignant cell invasion or as a result of cancer cells (tumor-associated). Cancer markers are not the primary modalities for cancer diagnosis rather they can be used as laboratory tests to support the diagnosis.

Abeomics has created a variety of cancer indicators, some of which PD-1, CD56, PD-L1, MMP2, PD-L2, and MUC4 aid scientists and researchers in doing studies more successfully.

The quality of the samples and equal loading are assessed using loading control antibodies. Proteins used as loading controls are generally chosen for their abundance and widespread expression in all cell types and tissues. Loading controls serve several functions in a Western blot analysis. First, loading controls offer a quantitative research approach that enables researchers to estimate the protein concentrations in each lane even when they have not been loaded uniformly. To account for the variations in loading, the density of the loading control band is implemented. Loading controls improve the quality of the data obtained by helping to correct mistakes and guarantee the correctness of the data utilized to draw important conclusions. Beta-actin and GADPH are two proteins with widespread high expression that are frequently utilized as loading controls.

Abeomics has created a variety of loading controls, including GAPDH, Beta actin, Beta Tubulin, and Anti-beta-tubulin, among others, to aid scientists and researchers in conducting their study effectively.

Stem cells are unspecialized cells with the ability to self-renew and develop into specific cell types, such as neurons, liver cells, or muscle cells. The differentiated cells that make up the tissues and organs of animals and plants are continuously produced from stem cells. Adult stem cells and embryonic stem cells are the two basic types of stem cells. Embryonic stem cells: Unwanted embryos are the source of the embryonic stem cells used in research today. These are the end result of in vitro fertilization. Adult stem cells come in two different varieties. One type originates from tissues that are completely grown, like the bone marrow, skin, and brain. Incremented pluripotent stem cells are the second kind. These are adult stem cells that have undergone laboratory modification to resemble embryonic stem cells more closely. Stem cells are significant in medical research and drug development because they have the potential to treat a number of ailments.

Abeomics offer a broad collection of stem cell antibodies used in many applications such as flow cytometry, cell screening, ELISAs, and western blotting. Some important stem cell antibodies include Polyclonal Antibody to Nanog, Polyclonal Antibody to ERAS, Polyclonal Antibody to Otx2, Polyclonal Antibody to MRF2, Monoclonal Antibody to Lif and Monoclonal Antibody to Wnt5A that are useful for scientists and researchers to conduct their research in an efficient manner.

A multicellular creature can go through processes known as development and differentiation whereby it begins with a single cell, the zygote, and develops into various tissues and organs made up of various cell types. Cellular differentiation, the establishment of tissues and organs, the division of cells, and the determination of body axes are all aspects of development. The recent development of bispecific antibodies presents exciting new possibilities for the creation of novel protein therapies. Bispecific antibodies can therefore be created to have unique properties that are missing from combinations of the two parental antibodies. The majority of bispecific antibodies are made to direct immune system’s cytotoxic effector cells toward diseased cells.

Abeomics offers a wide selection of high-quality antibodies for our customers, including polyclonal antibodies to Wnt5a, FMNL3, SIP1 receptor/Edg-1, APG16L, and DLL1. This ensures that our research customers have access to the precise materials they require for their investigations. We also provide a wide range of additional advantages to support our clients’ affordability, convenience, and dependability.

Secondary antibodies are essential tools in immunological research. They play a crucial role in detecting and amplifying signals generated by primary antibodies, which directly bind to target antigens. Secondary antibodies are raised against the species-specific immunoglobulins of primary antibodies, enabling researchers to perform multiple labeling and signal enhancement techniques in various experimental applications, such as Western blotting, immunohistochemistry, and flow cytometry. These versatile reagents are labeled with enzymes, fluorescent dyes, or other markers, making them indispensable for the visualization and quantification of specific antigens in complex biological samples.

Abeomics provides a diverse selection of secondary antibodies, catering to your research needs. Our range includes secondary antibodies derived from various host species.

Secondary antibodies are essential tools in immunological research. They play a crucial role in detecting and amplifying signals generated by primary antibodies, which directly bind to target antigens. Secondary antibodies are raised against the species-specific immunoglobulins of primary antibodies, enabling researchers to perform multiple labeling and signal enhancement techniques in various experimental applications, such as Western blotting, immunohistochemistry, and flow cytometry. These versatile reagents are labeled with enzymes, fluorescent dyes, or other markers, making them indispensable for the visualization and quantification of specific antigens in complex biological samples.

Abeomics provides a diverse selection of secondary antibodies, catering to your research needs. Our range includes secondary antibodies derived from various host species.